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2011 Fiscal Year Final Research Report

Role of signal transduction pathway of Bcl-3 and IkBNA in the pathogenesis of psoriasis

Research Project

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Project/Area Number 21390325
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionEhime University

Principal Investigator

HASHIMOTO Koji  愛媛大学, 先端研究・学術推進機構学術企画室, 特命教授 (00110784)

Co-Investigator(Kenkyū-buntansha) MURAKAMI Shinji  愛媛大学, 大学院医学系研究科, 准教授 (50175626)
Project Period (FY) 2009 – 2011
Keywords尋常性乾癬 / シグナル伝達 / 培養角化細胞 / NFkB / Bcl-3 / IkBNS
Research Abstract

In order to clarify the role of NF-kB in the pathogenesis of psoriasis, we examined whether pathological change of psoriasis was induced in IkBNS deficient mice. We also clarified the function of Bcl-3 in cultured epidermal keratinocytes. Although the IkBNS deficient mice did not spontaneously generate psoriatic skin phenotype, the psoriasis pathological change was induced by the wound stimulus and the TPA treatment. IL-22-induced psoriasis-related genes were suppressed by the pretreatment of Bcl-3 suppression. On the other hand, overexpression of Bcl-3 induced psoriasis-related gene expression. Furthermore, Bcl-3 was strongly detected psoriatic skin. In conclusion, NFkB and Bcl-3 play important roles in the pathogenesis of psoriasis.

Research Products

(32 results)

All 2012 2011 2010 2009

All Journal Article Presentation

  • [Journal Article] Targeted overexpression of Angptl6/angiopoietin-related growth factor in the skin promotes angiogenesis and lymphatic vessel enlargement in response to ultraviolet B2012

    • Author(s)
      Okazaki H, Hirakawa S, Shudou M, Nakaoka Y, Shirakata Y, Miyata K, Oike Y, Hashimoto K, Sayama K
    • Journal Title

      J Dermatol

      Volume: 39 Pages: 366-74

    • Peer Reviewed
  • [Journal Article] Interactions between myofibroblast differentiation and epidermogenesis in constructing human living skin equivalents2012

    • Author(s)
      Yang L, Hashimoto K, Tohyama M, Okazaki H, Dai X, Hanakawa Y, Sayama K, Shirakata Y
    • Journal Title

      J Dermatol Sci

      Volume: 65 Pages: 50-7

    • Peer Reviewed
  • [Journal Article] Epidermogenesis in a skin wound deep through the basement membrane contributes to scar formation2012

    • Author(s)
      Yang L, Hashimoto K, Shirakata Y
    • Journal Title

      Dermatol Sci

      Volume: 65 Pages: 224-226

    • Peer Reviewed
  • [Journal Article] Cell surface-annexins regulate ADAM-mediated ectodomain shedding of proamphiregulin2012

    • Author(s)
      Nakayama H, Fukuda S, Inoue H, Nishida-Fukuda H, Shirakata Y, Hashimoto K, Higashiyama S
    • Journal Title

      Mol Biol Cell

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Hair-inducing ability of human dermal papilla cells cultured under Wnt/β-catenin signalling activation2012

    • Author(s)
      Soma T, Fujiwara S, Shirakata Y, Hashimoto K, Kishimoto J
    • Journal Title

      Exp Dermatol

      Volume: 21 Pages: 307-9

    • Peer Reviewed
  • [Journal Article] Pathogenic Anti-Desmoglein 3 mAbs Cloned from a Paraneoplastic Pemphigus Patient by Phage Display2012

    • Author(s)
      Saleh MA, Ishii K, Yamagami J, Shirakata Y, Hashimoto K, Amagai M
    • Journal Title

      J Invest Dermatol

      Volume: 132 Pages: 1141-8

    • Peer Reviewed
  • [Journal Article] Possible involvement of CD14+ CD16+ monocyte lineage cells in the epidermal damage of Stevens-Johnson syndrome and toxic epidermal necrolysis2012

    • Author(s)
      Tohyama M, Watanabe H, Murakami S, Shirakata Y, Sayama K, Iijima M, Hashimoto K
    • Journal Title

      Br J Dermatol

      Volume: 166 Pages: 322-30

    • Peer Reviewed
  • [Journal Article] Development of NC1 and NC2 domains of Type VII collagen ELISA for the diagnosis and analysis of time course of epidermolysis bullosa acquisita patients2011

    • Author(s)
      Saleh MA, Ishii K, Kim Y, Murakami A, Ishii N, Hashimoto T, Schmidt E, Zillikens D, Shirakata Y, Hashimoto K, Kitajima Y, Amagai M
    • Journal Title

      J Dermatol Sci

      Volume: 62 Pages: 169-75

    • Peer Reviewed
  • [Journal Article] Genome-wide association study identifies HLA-A* 3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population2011

    • Author(s)
      Ozeki T, Mushiroda T, Yowang A, Takahashi A, Kubo M, Shirakata Y, Ikezawa Z, Iijima M, Shiohara T, Hashimoto K, Kamatani N, Nakamura Y
    • Journal Title

      Hum Mol Genet

      Volume: 20 Pages: 1034-41

    • Peer Reviewed
  • [Journal Article] Mite allergen is a danger signal for the skin via activation of inflammasome in keratinocytes2011

    • Author(s)
      Dai X, Sayama K, Tohyama M, Shirakata Y, Hanakawa Y, Tokumaru S, Yang L, Hirakawa S, Hashimoto K
    • Journal Title

      J Allergy Clin Immunol

      Volume: 127 Pages: 806-814

    • Peer Reviewed
  • [Journal Article] Nuclear translocation of phosphorylated STAT3 regulates VEGF-A-induced lymphatic endothelial cell migration and tube formation2011

    • Author(s)
      Okazaki H, Tokumaru S, Hanakawa Y, Shiraishi K, Shirakata Y, Dai X, Yang L, Tohyama M, Hashimoto K, Sayama K.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 412 Pages: 441-5

    • Peer Reviewed
  • [Journal Article] Auto-and cross-induction by betacellulininepidermal keratinocytes2010

    • Author(s)
      Shirakata Y, Tokumaru S, Sayama K, Hashimoto K
    • Journal Title

      J DermatolSci

      Volume: 162 Pages: 162-4

    • Peer Reviewed
  • [Journal Article] Inflammatory mediator TAK1 regulatesrashes hair follicle morphogenesis and anagen induction shown by using keratinocyte-specific TAK1-deficient mice2010

    • Author(s)
      Sayama K, Kajiya K, Sugawara K, Sato S, Hirakawa S, Shirakata Y, Hanakawa Y, Dai X, Ishimatsu-Tsuji Y, Metzger D, Chambon P, Akira S, Paus R, Kishimoto J, Hashimoto K
    • Journal Title

      PLoS One

      Volume: 5 Pages: 11275

    • Peer Reviewed
  • [Journal Article] E2 Polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity2010

    • Author(s)
      Sayama K, Yamamoto M, ShirakataY, Hirakawa S, Dai X, Tohyama M, Tokumaru S, Shin MS, Sakurai H, Akira S, Hashimoto K
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 30042-9

    • Peer Reviewed
  • [Journal Article] PPARγmediates innate immunity by regulating the 1α, 25-dihydroxyvitamin D3 induced hBD-3 and cathelicidin in human keratinocytes2010

    • Author(s)
      Dai X, Sayama K, Tohyama M, Shirakata Y, Hanakawa Y, Tokumaru S, Yang L, Hirakawa S, Hashimoto K
    • Journal Title

      J Dermatol Sci

      Volume: 60 Pages: 179-86

    • Peer Reviewed
  • [Journal Article] Occupational trichloroethylene hypersensitivity syndrome with human herpesvirus-6 and cytomegalovirus reactivation2010

    • Author(s)
      Watanabe H, Tohyama M, Komijima M, Nakajima T, Yohida T, Hashimoto K, and Iijima M
    • Journal Title

      Dermatology

      Volume: 221 Pages: 408-410

    • Peer Reviewed
  • [Journal Article] Fluctuation of blood and skin plasmacytoid dendritic cells in drug-induced hypersensitivity syndrome2010

    • Author(s)
      Sugita K, Tohyama M, Watanabe H, Otsuka A, Nakajima S, Iijima M, Hashimoto K, Tokura Y, Miyachi Y, Kabashima K
    • Journal Title

      J Allergy Clin Immunol

      Volume: 126 Pages: 408-410

    • Peer Reviewed
  • [Journal Article] Diagnosis and treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis with ocular complications2009

    • Author(s)
      Sotozono C, Ueta M, Koizumi N, Inatomi T, Shirakata Y, Ikezawa Z, HashimotoK, Kinoshita S
    • Journal Title

      Ophthalmology

      Volume: 116 Pages: 685-90

    • Peer Reviewed
  • [Journal Article] The influence of hepatic damage on serum soluble Fas ligand levels of patients with drug rashes2009

    • Author(s)
      Tohyama M, Shirakata Y, Sayama K, Hashimoto K
    • Journal Title

      J Allergy Clin Immunol

      Volume: 123 Pages: 971-2

    • Peer Reviewed
  • [Journal Article] Alteration of TLR3 pathways by glucocorticoids may be responsible for immunosusceptibility of human corneal epithelial cells to viral infections2009

    • Author(s)
      Hara Y, Shiraishi A, Kobayashi T, Kadota Y, Shirakata Y, Hashimoto K, Ohashi Y
    • Journal Title

      Mol Vis

      Volume: 15 Pages: 937-48

    • Peer Reviewed
  • [Journal Article] IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression2009

    • Author(s)
      Tohyama M, Hanakawa Y, Shirakata Y, Dai X, Yang L, Hirakawa S, Tokumaru S, Okazaki H, Sayama K, Hashimoto K
    • Journal Title

      Eur J Immunol

      Volume: 39 Pages: 2279-88

    • Peer Reviewed
  • [Journal Article] Living Skin Equivalents Constructed Using Human Amnions as a Matrix2009

    • Author(s)
      Yang L, Shirakata Y, Tokumaru S, Xiuju D, Tohyama M, Hanakawa Y, Hirakawa S, Sayama K, Hashimoto K
    • Journal Title

      J Dermatol Sci

      Volume: 56 Pages: 188-95

    • Peer Reviewed
  • [Journal Article] Nodal Lymphangiogenesis and Metastasis : Role of Tumor-Induced Lymphatic Vessel Activation in Extramammary Paget's Disease2009

    • Author(s)
      Hirakawa S, Detmar M, Kerjaschki D, Nagamatsu S, Matsuo K, Tanemura A, Kamata N, Higashikawa K, Okazaki H, Kameda K, Nishida-Fukuda H, Mori H, Hanakawa Y, Sayama K, Shirakata Y, Tohyama M, Tokumaru S, Katayama I, Hashimoto K
    • Journal Title

      Am J Pathol

      Volume: 175 Pages: 2235-48

    • Peer Reviewed
  • [Presentation] Deletion of SOCS3 in the epidermis causes impaired skin wound healing in vivo2010

    • Author(s)
      Shirakata Y, Yang L, Tsuda T, Tohyama M, Miyawaki S, Kameda K, Sayama K, Yoshimura A, Hashimoto K
    • Organizer
      The 40^h Annual Meeting of the European Society for Dermatological Research
    • Place of Presentation
      Helsinki, Finland
    • Year and Date
      20100908-11
  • [Presentation] Interferon alpha enhances IL-22 receptor expression on epidermal keratinocytes2010

    • Author(s)
      Tohyama M, Yang L, Tsuda T, Miyawaki S, Shirakata Y, Sayama K, Hashimoto K
    • Organizer
      The 40^h Annual Meeting of the European Society for Dermatological Research
    • Place of Presentation
      Helsinki, Finland
    • Year and Date
      20100908-11
  • [Presentation] Mite allergen is a danger signal for the skin2010

    • Author(s)
      Sayama K, Dai X, Shirakata Y, Tohyama M, Miyawaki S, Hirakawa S, Hashimoto K
    • Organizer
      The 40^h Annual Meeting of the European Society for Dermatological Research
    • Place of Presentation
      Helsinki, Finland
    • Year and Date
      20100908-11
  • [Presentation] Successful treatment of severe pemphigus vulgaris with high-dose intravenous immunoglobulin2010

    • Author(s)
      Shirakata Y, Ishikawa M, Murakami S, Hashimoto K
    • Organizer
      9^<th> Meeting of the German-Japanese Society of Dermatology
    • Place of Presentation
      Weimar, Germany
    • Year and Date
      20100609-12
  • [Presentation] Overlap between the Drug-induced hypersensitivity syndrome and the Stevens Johnson Syndrome2010

    • Author(s)
      Hashimoto K
    • Organizer
      4^<th> International Drug Hypersensitivity Meeting
    • Year and Date
      2010-06-10
  • [Presentation] Simple method of constructing living skin equivalent using human amnion as dermal matrix2009

    • Author(s)
      Shirakata Y, Yang L, Sayama K, and Hashimoto K
    • Organizer
      The 39^<th> Annual Meeting of European Society for Dermatological Research
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      20090910-12
  • [Presentation] Development of a new skin equivalent using de-epithelialized amnion membrane2009

    • Author(s)
      Shirakata Y and Hashimoto K
    • Organizer
      The 4^<th> Joint Meeting of Japanese Dermatological Association and Australasian College of Dermatologists
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      20090710-12
  • [Presentation] Lymph node lymphangiogenesis-a new concept in cancer metastasis2009

    • Author(s)
      Hirakawa S, and Hashimoto K
    • Organizer
      Symposium in 7^<th> World Congress on Melanoma and 5^<th> Congress of the European Association of Dermato-Oncology(EADO)
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      20090512-16
  • [Presentation] Inflammatory mediator TAK1 regulates hair follicle cycling2009

    • Author(s)
      Sayama K, Shirakata Y, Ishimatsu-Tsuji Y, Kajiya K, Hirakawa S, Sugawara K, Chambon P, Akira S, Paus R, Kishimoto J, and Hashimoto K
    • Organizer
      The 69^<th> Annual Meeting of Society for Investigative Dermatology
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      20090506-09

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Published: 2013-07-31  

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