皮膚T細胞性リンパ腫のAID関連microRNAによるモニタリングシステムの構築

2011 Fiscal Year Annual Research Report

• Project/Area Number: 21390328
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: 戸倉 新樹 浜松医科大学, 医学部, 教授 (00172156)
• Co-Investigator(Kenkyū-buntansha): 中村 元信 産業医科大学, 医学部, 准教授 (30303837) ; 島内 隆寿 浜松医科大学, 医学部, 講師 (90399204)
• Keywords: 皮膚T細胞リンパ腫 / AID / 成人T細胞白血病/リンパ腫 / マイクロRNA / 菌状息肉症 / セザリー症候群

Research Abstract

AIDはBリンパ球の抗体遺伝子可変領域の点突然変異と抗体のクラススイッチに関与するたんぱく質として同定されたが、AIDは癌化した胃癌や肝臓癌の細胞に高発現し、発癌にも大きく関与していることが提唱された。また、肝炎ウイルスの感染により、AIDの発現が上昇することから、ウイルス性発癌におけるAIDの役割が注目されている。さらに、microRNA-155がAIDmRNAの非翻訳領域に結合し、AIDの発現を負に発現していることが明らかとなった。皮膚リンパ腫患者(成人T細胞白血病/リンパ腫(ATLL)を含む)ではこれまでp53などさまざまな癌抑制遺伝子の点突然変異が報告されている。ATLL、菌状息肉症、セザリー症候群の患者から同意を得た後、採血し、フィコール法により、リンパ球を分離した後、mRNA、microRNAを抽出し、AIDmRNA、microRNA-155の発現量をreal-time PCR法により測定し、コントロールである健常人リンパ球における発現量と比較した。その結果、AID発現はひふT細胞リンパ腫の組織、末梢血で高く、とりわけATLLにおいて高値であることが明らかとなった。さらに、患者リンパ球をMACS法によりCD4陰性、CD4陽性CD25陰性、CD4陽性CD25陽性細胞に分離し、それぞれの分画のAIDmRNA、microRNA-155の発現量を測定した。生検時に得られた患者皮膚、リンパ節検体の一部のAIDmRNA、microRNA-155の発現量も測定し、AID発現がmicroRNA-155の低発現を伴って高い値を示すことが明らかとなった。本研究により、皮膚リンパ腫においてAIDが腫瘍化に関連し、とくにウイルス性腫瘍化寄稿に深く関わっていることが示唆された。

Research Products

• [Journal Article] The type of skin eruptions is an independent prognostic indicator for adult T-cell leukemia/lymphoma (2011)
  • Author(s): Sawada Y, Hino R, Hama K, Ohmori S, Fueki H, Yamada S, Fukamachi S, Tajiri M, Kumo R, Yoshioka M, Nakashima D, Sugita K, Yoshiki R, Shimauchi T, Mori T, Izu K, Kobayashi M, Nakamura M, Tokura Y
  • Journal Title: Blood Volume: 117 Pages: 3961-3967
  • Peer Reviewed
• [Journal Article] High levels of activation-induced cytidine deaminase expression in adult T-cell leukaemia/lymphoma (2011)
  • Author(s): Nakamura M, Sugita K, Sawada Y, Yoshiki R, Hino R, Tokura Y
  • Journal Title: Br J Dermatol Volume: 165 Pages: 437-439
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• [Journal Article] Elevated expression of activation-induced cytidine deaminase in T and NK cells from patients with chronic active Epstein-Barr virus infection (2011)
  • Author(s): Nakamura M, Iwata S, Kimura H, Tokura Y
  • Journal Title: Eur J Dermatol Volume: 21 Pages: 780-782
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• [Journal Article] Cutaneous pseudolymphoma due to benidipine hydrochloride with massive infiltration of eosinophils (2011)
  • Author(s): Fukamachi S, Sugita K, Nakamura M, Tokura Y
  • Journal Title: J Dermatol Volume: 38 Pages: 935-936
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• [Journal Article] Keloid exacerbation associated with adult T-cell leukemia/lymphoma cell infiltration (2011)
  • Author(s): Sawada Y, Mori T, Yamada S, Nakamura M, Tokura Y
  • Journal Title: Eur J Dermatol Volume: 21 Pages: 646-647
  • Peer Reviewed
• [Journal Article] Epithelial-mesenchymal transition in the skin (2011)
  • Author(s): Nakamura M, Tokura Y
  • Journal Title: J Dermatol Sci Volume: 61 Pages: 7-13
  • Peer Reviewed
• [Journal Article] Topical cholecystokinin depresses itch-associated scratching behavior in mice (2011)
  • Author(s): Fukamachi S, Mori T, Sakabe J-I, Shiraishi N, Kuroda E, Kobayashi M, Bito T, Kabashima K, Nakamura M, Tokura Y
  • Journal Title: J Invest Dermatol Volume: 131 Pages: 956-961
  • Peer Reviewed
• [Journal Article] Modulation of semaphorin 3A expression by calcium concentration and histamine in human keratinocytes and fibroblasts (2011)
  • Author(s): Fukamachi S, Bito T, Shiraishi N, Kobayashi M, Kabashima K, Nakamura M, Tokura Y
  • Journal Title: J Dermatol Sci Volume: 62 Pages: 118-123
  • Peer Reviewed
• [Journal Article] Inhibition of epidermal growth factor receptor and P13K/Akt signaling suppresses cell proliferation and survival through regulation of Stat3 activation in human cutaneous squamous cell carcinoma (2011)
  • Author(s): Bito T, Sumita N, Ashida M, Budiyanto A, Ueda M, Ichihashi M, Tokura Y, Nishigori C
  • Journal Title: J Skin Cancer Volume: 2011 Pages: 874571
  • Peer Reviewed
• [Journal Article] Efficacy of combined topical treatment of acne vulgaris with adapalene and nadifloxacin : A randomized study (2011)
  • Author(s): Kobayashi M, Nakagawa T, Fukamachi K, Nakamura M, Tokura Y
  • Journal Title: J Dermatol Volume: 38 Pages: 1163-1166
  • Peer Reviewed
• [Journal Article] Downmodulatory effects of cetirizine and levocetirizine on cytokine/chemokine production and CD54 expression in keratinocytes (2011)
  • Author(s): Kobayashi M, Tokura Y
  • Journal Title: J Dermatol Volume: 38 Pages: 717-719
  • Peer Reviewed
• [Journal Article] Circulating Th17 cell fluctuation in psoriatic patients treated with topical calcipotriol and betamethasone butyrate propionate (2011)
  • Author(s): Hino R, Kabashima R, Kawakami C, Sugita K, Nakamura M, Tokura Y
  • Journal Title: J Eur Acad Dermatol Venereol Volume: 25 Pages: 242-244
  • DOI: 10.1111/j.1468-3083.2010.03714.X.
  • Peer Reviewed
• [Journal Article] Therapeutic efficacy of mizoribine for discoid lupus erythematosus with normalized frequency of circulating T helper 17 cells (2011)
  • Author(s): Sugita K, Kabashima R, Kawakami C, Nakamura M, Tokura Y
  • Journal Title: Clin Exp Dermatol Volume: 36 Pages: 315-317
  • DOI: 10.1111/j.1365-2230.2010.03971.x
  • Peer Reviewed
• [Journal Article] Characterization of Peripheral Natural Killer Cells and their Reduction in Drug-induced Hyper-sensitivitv Syndrome (2011)
  • Author(s): Sugita K, Kabashima K, Tokura Y
  • Journal Title: Acta Derm Venereol Volume: 92 Pages: 83-84
  • Peer Reviewed
• [Journal Article] Increased expression of mRNAs for IL-4, IL-17, IL-22 and IL-31 in skin lesions of subacute and chronic forms of prurigo (2011)
  • Author(s): Park K, Mori T, Nakamura M, Tokura Y
  • Journal Title: Eur J Dermatol Volume: 21 Pages: 135-136
  • Peer Reviewed
• [Journal Article] Molecular Mapping of Lymph Node Metastases by Real-Time RT-PCR in Two Melanoma Patients (2011)
  • Author(s): Abe-Mukumoto S, Mori T, Sakabe JI, Fukamachi S, Nakamura M, Kabashima K, Tokura Y
  • Journal Title: J Dermatol Volume: 38 Pages: 1202-1205
  • DOI: 10.1111/j.1346-8138.2011.01204.x
  • Peer Reviewed
• [Journal Article] Inflammatory cytokine expression in the skin lesions of tumour necrosis factor receptor-associated periodic syndrome (2011)
  • Author(s): Ohmori S, Nakamura M, Hino R, Kobayashi M, Tokura Y
  • Journal Title: Rheumatology Volume: 51 Pages: 196-199
  • Peer Reviewed
• [Journal Article] High-Mobility Group Box 1 Protein (HMGB1) as a Novel Diagnostic Tool for Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome (2011)
  • Author(s): Nakajima S, Watanabe H, Tohyama M, Sugita K, Iijima M, Hashimoto K, Tokura Y, Nishimura Y, Doi H, Tanioka M, Miyachi Y, Kabashima K
  • Journal Title: Arch Dermatol Volume: 147 Pages: 1110-1112
  • Peer Reviewed
• [Journal Article] Multiple milia and comedones as a skin manifestation of systemic amyloidosis (2011)
  • Author(s): Funai N, Machida S, Ito T, Hirakawa S, Tokura Y
  • Journal Title: Eur J Dermatol Volume: 21 Pages: 638-639
  • Peer Reviewed
• [Journal Article] High-dose Intravenous Immunoglobulin Monotherapy for Drug-induced Hypersensitivity Syndrome (2011)
  • Author(s): Kito Y, Ito T, Hashizume H, Tokura Y
  • Journal Title: Acta Derm Venereol Volume: 92 Pages: 100-101
  • Peer Reviewed
• [Journal Article] Raynaud's phenomenon, digital gangrene and hypergammaglobulinemic purpura occurring in a patient with IgG4-related disease (2011)
  • Author(s): Ikawa T, Kasuya A, Hirakawa S, Tokura Y
  • Journal Title: Br J Dermatol Volume: 165 Pages: 1359-1366
  • DOI: 10.1111/j.1365-2133.2011.10609.x
  • Peer Reviewed
• [Journal Article] Superficial angiomyxoma on the scrotum of a child (2011)
  • Author(s): Nakamura M, Tokura Y
  • Journal Title: Pediatr Dermatol Volume: 28 Pages: 200-201
  • DOI: 10.1111/j.1525-1470.2011.01389.x
  • Peer Reviewed
• [Journal Article] Angiolymphoid hyperplasia with eosinophilia on the leg successfully treated with Th2 cytokine inhibitor suplatast tonsilate (2011)
  • Author(s): Bito T, Kabashima R, Sugita K, Tokura Y
  • Journal Title: J Dermatol Volume: 38 Pages: 300-302
  • DOI: 10.1111/j.1346-8138.2010.00990.x
  • Peer Reviewed
• [Journal Article] Epiletic seizures and cholinergic urticaria with generalized hypohidrosis and anhidrosis (2011)
  • Author(s): Sawada Y, Bito T, Kabashia R, Sugita K, Nakamura M, Tokura Y
  • Journal Title: Eur J Dermatol Volume: 21 Pages: 99-100
  • Peer Reviewed
• [Journal Article] Necrobiosis lipoidica of the scrotum (2011)
  • Author(s): Sawada Y, Mori T, Nakashima D, Nakamura M, Tokura Y
  • Journal Title: Eur J Dermatol Volume: 21 Pages: 98-99
  • Peer Reviewed
• [Journal Article] Recurrent annular erythema after thymectomy (2011)
  • Author(s): Sawada Y, Nakamura M, Tokura Y
  • Journal Title: Eur J Dermatol Volume: 21 Pages: 425-426
  • Peer Reviewed
• [Journal Article] Generalized fixed drug eruption caused by pazufloxacin (2011)
  • Author(s): Sawada Y, Nakamura M, Tokura Y
  • Journal Title: Acta Derm Venereol Volume: 91 Pages: 600-601
  • Peer Reviewed
• [Journal Article] Schwannomatosis presenting with large subcutaneous and retroperitoneal tumours (2011)
  • Author(s): Yoshizawa M, Sugita K, Haruyama S, Yoshiki R, Hino R, Bito T, Nakamura M, Tokura Y
  • Journal Title: Clin Exp Dermatol Volume: 36 Pages: 555-557
  • DOI: 10.1111/j.1365-2230.2011.04018.x
  • Peer Reviewed
• [Journal Article] Atypical large bullae caused by herpes simplex in a patient with thymoma (2011)
  • Author(s): Fueki H, Sugita K, Sawada Y, Nakamura M, Tokura Y
  • Journal Title: Eur J Dermatol Volume: 21 Pages: 435-436
  • Peer Reviewed
• [Journal Article] Acquired poikiloderma associated with primary biliary cirrhosis (2011)
  • Author(s): Fueki H, Sugita K, Nakamura M, Tokura Y
  • Journal Title: Eur J Dermatol Volume: 21 Pages: 118
  • Peer Reviewed
• [Journal Article] Calcinosis cutis associated with primary Sjogren's syndrome ; strong expression of osteonectin and matrix Gla protein (2011)
  • Author(s): Fueki H, Hino R, Nakamura M, Tokura Y
  • Journal Title: Rheumatology (Oxford) Volume: 50 Pages: 2318-2320
  • Peer Reviewed
• [Journal Article] A case of cholinergic urticaria associated with acquired generalized hypohidrosis and reduced acetylcholine receptors : cause and effect? (2011)
  • Author(s): Nakamizo S, Kurosawa M, Sawada Y, Tokura Y, Miyachi Y, Kabashima K
  • Journal Title: Clin Exp Dermatol Volume: 36 Pages: 559-560
  • DOI: 10.1111/j.1365-2230.2011.04015.x
  • Peer Reviewed
• [Journal Article] Sebaceous carcinoma arising at a chronic candidiasis skin lesion of apatient with keratitis-ichthyosis-deafness (KID) syndrome (2011)
  • Author(s): Kaku Y, Tanizaki H, Tanioka M, Sakabe J, Miyagawa-Hayashino A, Tokura Y, Miyachi Y, Kabashima K
  • Journal Title: Br J Dermatol Volume: 166 Pages: 222-224
  • DOI: 10.1111/j.1365-2133.2011.10521.x
  • Peer Reviewed
• [Journal Article] Fonsecaea Monophoraによるクロモブラストミコーシス (2011)
  • Author(s): 杉山由華, 鈴木陽子, 菅谷圭子, 戸倉新樹, 矢口貴志, 亀井克彦, 西村和子
  • Journal Title: Medical Mycology Journal Volume: 52 Pages: 255-260
  • DOI: 10.3314/mmj.52.255
  • Peer Reviewed
• [Journal Article] アトピー性皮膚炎に対するタクロリムス軟膏の使用経験-全身への外用療法による皮疹とQOLの改善- (2011)
  • Author(s): 伊豆邦夫, 森智子, 戸倉新樹
  • Journal Title: Progress in Medicine Volume: 31 Pages: 1573-1577
  • Peer Reviewed
• [Journal Article] 日光角化症とBowen病に対するメタルハライドランプを用いた光線力学両方(PDT)の治療効果の検討 (2011)
  • Author(s): 尾藤利憲, 大森俊, 吉澤真衣子, 春山護人, 澤田雄宇, 川上千佳, 椛島利江子, 椋本祥子, 杉田和成, 吉木竜太郎, 日野亮介, 森智子, 小林美和, 中村元信, 戸倉新樹
  • Journal Title: 西日本皮膚科 Volume: 73 Pages: 260-265
  • Peer Reviewed
• [Journal Article] Rosacea-like demodicosis mimicking cutaneous lymphoma
  • Author(s): Kito Y, Hashizume H, Tokura Y
  • Journal Title: Acta Derm Venereol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Pathogenesis of alopecia areata : why does alopecia areata develop in a round pattern?
  • Author(s): Nakamura M, Tokura Y
  • Journal Title: Exp Dermatol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Decreased expression of homeostatic chemokine receptors in intravascular large B-cell lymnhoma : A study of three cases
  • Author(s): Kasuya A, Fujiyama T, Shirahama S, Hashizume H, Tokura Y
  • Journal Title: Eur J Dermatol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Blocking of CTLA-4 on lymphocytes improves the sensitivity of lymphocyte transformation test in a patient with nickel allergy
  • Author(s): Sugita K, Kabashima K, Sawada Y, Haruyama S, Yoshioka M, Mori T, Ogasawara K, Tokura Y
  • Journal Title: Eur J Dermatol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Alopecia areata triggered or exacerbated by swine flu virus infection
  • Author(s): Ito T, Tokura Y
  • Journal Title: J Dermatol Volume: (in press)
  • DOI: 10.1111/j.1346-8138.2011.01437.x
  • Peer Reviewed
• [Journal Article] Eruptive milium-like syringoma showing eccrine duct origin of milia
  • Author(s): Tatsuno K, Yagi H, Tokura Y
  • Journal Title: J Dermatol Volume: (in press)
  • DOI: 10.1111/j.1346-8138.2011.01444.x
  • Peer Reviewed
• [Journal Article] Histiocytoid Sweet's syndrome associated with t(9;22)(q34;q11)-positive chronic myelogenous leukemia : Immature granulocytic origin of histiocvtic cells
  • Author(s): Kasuya A, Fujiyama T, Hashizume H, Inuzuka M, Tokura Y
  • Journal Title: Int J Dermatol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Haemodialysis-induced pseudoporphyria successfully treated with glutathione
  • Author(s): Kasuya A, Hashizume H, Tokura Y
  • Journal Title: Eur J Dermatol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Connexin 26 (GJB2) mutations in keratitis-ichthyosisdeafness (KID) syndrome presenting with squamous cell carcinoma
  • Author(s): Sakabe J-I, Yoshiki R, Sugita K, Haruyama S, Sawada Y, Kabashima R, Bito T, Nakamura M, Tokura Y
  • Journal Title: J Dermatol Volume: (in press)
  • DOI: 10.1111/j.1346-8138.2011.01414.x
  • Peer Reviewed
• [Journal Article] Acute onset disseminated superficial porokeratosis associated with exacerbation of diabetes mellitus due to development of anti-insulin antibodies
  • Author(s): Nakamura M, Fukamachi S, Tokura Y
  • Journal Title: Dermatoendocrinol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Congenital onychodysplasia of the index finger in a child with meconium aspiration syndrome
  • Author(s): Nakamura M, Tokura Y
  • Journal Title: Int J Dermatol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Methylmalonic aciduria presenting with recurrent multiple molluscum contagiosum lesions
  • Author(s): Nakamura M, Tokura Y
  • Journal Title: Dermatoendocrinol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Tuberculosis verrucosa cutis with elevation of circulating Th1 and Th17 cells and their reductions after successful treatment
  • Author(s): Fukamachi S, Kawakami C, Kabashima R, Sawada Y, Sugita K, Nakamura M, Tokura Y
  • Journal Title: J Dermatol Volume: (in press)
  • DOI: 10.1111/j.1346-8138.2011.01317.x
  • Peer Reviewed
• [Journal Article] A high serum concentration of chemerin in pustular dermatitis paradoxically induced by etanercept
  • Author(s): Sawada Y, Nakamura M, Hama K, Hino R, Tokura Y
  • Journal Title: J Am Acad Dermatol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Occupational skin cancer arising in a patient with a high frequency of circulating regulatory T cells
  • Author(s): Ohmori S, Mori T, Haruyama S, Sawada Y, Hino R, Nakamura M, Tokura Y
  • Journal Title: Int J Dermatol Volume: (in press)
  • Peer Reviewed
• [Presentation] Th17細胞と皮膚疾患 (2011)
  • Author(s): 戸倉新樹
  • Organizer: 第39回日本臨床免疫学会総会
  • Place of Presentation: 東京都(招待講演)
  • Year and Date: 20110915-20110917
• [Presentation] Skin barrier impairment is heterogeneous in atopic dermatitis (2011)
  • Author(s): Tokura Y
  • Organizer: The 36th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: Kyoto, Japan(招待講演)
  • Year and Date: 2011-12-10
• [Presentation] Atopic dermatitis and skin barrier in the extrinsic and intrinsic types (2011)
  • Author(s): Tokura Y
  • Organizer: The 37^<th> Annual Meeting of the Taiwanese Dermatological Association
  • Place of Presentation: Taipei, Taiwan(招待講演)
  • Year and Date: 2011-11-26
• [Presentation] 内因性アトピー性皮膚炎 (2011)
  • Author(s): 戸倉新樹
  • Organizer: 第62回日本皮膚科学会中部支部学術大会
  • Place of Presentation: 四日市(招待講演)
  • Year and Date: 2011-11-20
• [Presentation] 外来性物質に対する皮膚アレルギー反応機構 (2011)
  • Author(s): 戸倉新樹
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京都(招待講演)
  • Year and Date: 2011-11-11
• [Presentation] 薬剤アレルギーにおけるT細胞,NK細胞,樹状細胞の変動 (2011)
  • Author(s): 杉田和成, 椛島健治, 中村元信, 戸倉新樹
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京都(招待講演)
  • Year and Date: 2011-11-11
• [Presentation] 紫外線による免疫抑制を考える (2011)
  • Author(s): 戸倉新樹
  • Organizer: 日本皮膚科学会愛媛地方会佐山浩二教授就任記念第54回学術大会
  • Place of Presentation: 松山市(招待講演)
  • Year and Date: 2011-09-24
• [Presentation] Adult T-cell leukemia/lymphoma : Treg neoplasm with affinity to the skin (2011)
  • Author(s): Tokura Y
  • Organizer: International Immunodennatology Symposium (Post-ESDR 2011)
  • Place of Presentation: Heidelberg, Germany(招待講演)
  • Year and Date: 2011-09-12
• [Presentation] 成人T細胞性白血病/リンパ腫の皮疹型と予後の解析 (2011)
  • Author(s): 戸倉新樹, 澤田雄宇
  • Organizer: 第27回日本皮膚悪性腫瘍学会学術大会
  • Place of Presentation: 東京都(招待講演)
  • Year and Date: 2011-06-04
• [Presentation] Adult T-cell leukemia /lymphoma and HTLV-1. Cutaneous Lymphomas of Viral Origin (2011)
  • Author(s): Tokura Y
  • Organizer: 22^<nd> World Congress of Dermatology
  • Place of Presentation: Seoul, Korea(招待講演)
  • Year and Date: 2011-05-27
• [Presentation] Immunosuppression and Complications in the Disordered Axis of-TNF-α and Th17 Cells (2011)
  • Author(s): Tokura Y
  • Organizer: 22^<nd> World Congress of Dermatology
  • Place of Presentation: Seoul, Korea(招待講演)
  • Year and Date: 2011-05-25
• [Presentation] Extrinsic and intrinsic types of atopic dermatitis. Ancillary Meeting on Atopic Dermatitis (2011)
  • Author(s): Tokura Y
  • Organizer: 22^<nd> World Congress of Dermatology 2011
  • Place of Presentation: Seoul, Korea(招待講演)
  • Year and Date: 2011-05-24
• [Presentation] Recent concept on the role of cutaneous dendritic cells in UVB-induced immunosuppression (2011)
  • Author(s): Tokura Y
  • Organizer: 22^<nd> World Congress of Dermatology 2011
  • Place of Presentation: Seoul, Korea(招待講演)
  • Year and Date: 2011-05-24
• [Presentation] Photoimmunology : sensitization and suppression (2011)
  • Author(s): Tokura Y
  • Organizer: Australasian Society for Dermatology Research 2011 Annual Scientific Meeting
  • Place of Presentation: Perth, Australia(招待講演)
  • Year and Date: 2011-05-19
• [Book] Hypersensitivity to mosquito bites and EBV (2011)
  • Author(s): Tokura Y
  • Total Pages: 423-428
  • Publisher: MEDRANG
• [Book] 高齢者の皮膚トラブルFAQ (2011)
  • Author(s): 戸倉新樹
  • Total Pages: 2
  • Publisher: 診断と治療社
• [Book] 皮膚科臨床アセット1.アトピー性皮膚炎 (2011)
  • Author(s): 戸倉新樹
  • Total Pages: 6
  • Publisher: 中山書店
• [Book] 皮膚科臨床アセット2.薬疹診療のフロントライン (2011)
  • Author(s): 戸倉新樹
  • Total Pages: 6
  • Publisher: 中山書店
• [Book] 皮膚疾患最新の治療2011-2012 (2011)
  • Author(s): 戸倉新樹
  • Total Pages: 1
  • Publisher: 南江堂
• [Book] 皮膚科診療カラーアトラス大系 (2011)
  • Author(s): 戸倉新樹
  • Total Pages: 4
  • Publisher: 講談社
• [Book] 皮膚悪性腫瘍取扱い規約第2版 (2011)
  • Author(s): 戸倉新樹
  • Total Pages: 6
  • Publisher: 金原出版
• [Book] 臨床医必携-全身とかゆみ (2011)
  • Author(s): 戸倉新樹
  • Total Pages: 3
  • Publisher: 診断と治療社