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2011 Fiscal Year Final Research Report

Development of high spatial resolution molecular imaging system

Research Project

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Project/Area Number 21390339
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKitasato University

Principal Investigator

TAKEDA Tohoru  北里大学, 医療衛生学部, 教授 (10197311)

Co-Investigator(Kenkyū-buntansha) YUASA Tetsuya  山形大学, 大学院・理工学研究科, 教授 (30240146)
Project Period (FY) 2009 – 2011
Keywordsエックス線 / CT
Research Abstract

High spatial molecular imaging system with fluorescent X-ray technique is being developed. In this system, fluorescent X-ray signal of target elements is obtained by exiting the monochromatic sheet X-ray beam together with absorption X-ray image. Good CT images were obtained from 25 keV to 52 keV X-ray energy in phantom and biological objects within less than 1 min. The positioning of small animal and the anatomical structure of object can be imaged using this new detector system. CT image will be obtained shortly for in-vivo study.

  • Research Products

    (32 results)

All 2012 2011 2010 2009 Other

All Journal Article (21 results) Presentation (8 results) Book (3 results)

  • [Journal Article] In vivo physiological saline-infused hepatic vessel imaging using two-crystal-interferometer-based phase-contrast X-ray technique2012

    • Author(s)
      Takeda T, Yoneyama Y, Wu J, Thet-Thet-Lwin, Momose A, Hyodo K.
    • Journal Title

      J. Synchrotron Rad

      Volume: 19 Pages: 252-256

  • [Journal Article] Sequential imaging analysis using MIBG scintigraphy revealed progressive degeneration of cardiac sympathetic nerve in Parkinson's disease2011

    • Author(s)
      Watanabe M, Takeda T, Nakamagoe K, Tamaoka A
    • Journal Title

      Eur J Neuro

      Volume: 18 Pages: 1010-1013

  • [Journal Article] Nondestructive imaging of anomalously preserved methane clathrate hydrate by phase contrast X-ray imaging2011

    • Author(s)
      Takeya S, Yoneyama A, Ueda K, Takeda T, et al
    • Journal Title

      J Phys Chem

      Volume: 115 Pages: 16193-16199

  • [Journal Article] Synchrotron-based x-ray fluorescence, imaging and elemental mapping from biological samples2011

    • Author(s)
      Rao D. V, Swapna M, Cesareo R, Brunetti A, Akatsuka T, Yuasa T, Takeda T, G. E. Gigante
    • Journal Title

      PRAMANA-J Phys

      Volume: 76 Pages: 261-2697

  • [Journal Article] Use of synchrotron-based diffraction-enhanced imaging for visualization of soft tissues in invertebrates2011

    • Author(s)
      Rao DV, Swapna M, Cesareo R, Brunetti A, Zhong Z, Akatsuka T, Yuasa T, Takeda T, Gigante GE
    • Journal Title

      Appl. Rad & Isotop

      Volume: 68 Pages: 1987-1993

  • [Journal Article] Phase I clinical study of NMK36 : a new PET tracer with synthetic amino acid analogue anti-[18F] FACBC2011

    • Author(s)
      Asano Y, Inoue Y, Ikeda Y, Kikuchi K, Hara T, Taguchi C, Tokushige H, Maruo H, Takeda T, Nakamura T, Fujita T, Kumagai Y, Hayakawa K
    • Journal Title

      Ann Nucl Med

      Volume: 25 Pages: 414-418

  • [Journal Article] Development of 30-picoradian-picoradian positioning system for X-ray interferometer and Its application for phase-contrast X-ray imaging2011

    • Author(s)
      Yoneyama A, Takeya S, Hyodo K, Ueda K, Takeda T
    • Journal Title

      Microscope

      Volume: 46 Pages: 71-74

  • [Journal Article] Phase-contrast X-ray imaging of the gas diffusion layer of fuel cells2010

    • Author(s)
      Takeya S, Yoneyama A, Miyamoto J, Gotoh Y, Ueda K, Kyodo K, Takeda T
    • Journal Title

      J. Synchrotron Rad

      Volume: 17 Pages: 813-816

  • [Journal Article] A practical method of determining cross-calibration factors of PET scanners by moving a point-like 22 Na radioactive source2010

    • Author(s)
      Hasegawa T, Oda K, Wada Y, Sato Y, Yamada T, Yoshida E, Murayama H, Saito K, Takeda T, Kikuchi K
    • Journal Title

      Ann Nucl Med

      Volume: 24 Pages: 655-661

  • [Journal Article] Increased cerebral blood flow in primary somatosensory region related to somatichal lucination in the elderly2010

    • Author(s)
      Nemoto K, Mizukami K, Hori T, Kawai N, Kawanishi Y, Ota M. Takeda T, Sato N, Ohnishi T, Matsuda H, Asada T
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 64 Pages: 341-445

  • [Journal Article] X-ray imaging studies using synchrotron radiation2010

    • Author(s)
      Takeda T, Yoneyama A, Yuasa T, Akatsuka T, Wu J
    • Journal Title

      Proc International Conference on Nanotechnology & Medical Sciences

      Pages: 24-25

  • [Journal Article] Synchrotron-based scattered radiation from phantom materials used in X-ray CT2010

    • Author(s)
      Rao DV, Swapna M, Cesareo R, Brunetti A, Akatsuka T, Yuasa T, Takeda T, Gigante GE
    • Journal Title

      J. X-Ray Sci & Tech

      Volume: 18 Pages: 327-337

  • [Journal Article] Cork embedded internal features and contrast mechanisms with dei using 18, 20, 30, 36, and 40keV synchrotron X-Ray2010

    • Author(s)
      Rao DV, Cesareo R, Brunetti A, Zhong Z, Yuasa T, Akatsuka T, Takeda T, Gigante G. E
    • Journal Title

      Res Nondestructive Evaluation

      Volume: 21 Pages: 171-183

  • [Journal Article] Synchrotron based diffraction-enhanced imaging to visualize the embedded physiology, soft-anatomy and contrast mechanisms of invertebrates2010

    • Author(s)
      Rao DV, Swapna M., Cesareo R, Brunetti A, Zhong Z, Akatsuka T, Yuasa T, Takeda T, and Gigante G. E
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 68 Pages: 1687-1693

  • [Journal Article] X-Ray phase-contrast microtomography for visualizing of renal microstuctures in albino-panda-albino hamsters2009

    • Author(s)
      Wu J, Takeda T, Momose A
    • Journal Title

      Spring-8 Research Frontiers

      Pages: 44-45

  • [Journal Article] X-ray fluorescent CT imaging of cerebral uptake of stable-iodine perfusion agent iodoamphetamine analog IMP in mice2009

    • Author(s)
      Takeda T, Wu J, Thet-Thet-Lwin
    • Journal Title

      J. Synchrotron Rad

      Volume: 16 Pages: 57-62

  • [Journal Article] Imaging renal structures by x-ray phase-contrast microtomography2009

    • Author(s)
      Wu J, Takeda T, Thet-Thet-Lwin, Momose A, Sunaguchi N, Fukami T, Yuasa T, Akatsuka T
    • Journal Title

      Kidney International

      Volume: 75 Pages: 945-951

  • [Journal Article] Imaging properties of fluorescent X. ray CT comparison study2009

    • Author(s)
      Huo Q, Sato H, Takeda T, Wu J, Thet-Thet-Lwin, Yuasa T, Hyodo K, Akatsuka T
    • Journal Title

      Information and communication Engineers MI 2008-142(2009-01)

      Pages: 375-379

  • [Journal Article] Generation of the map of myocardial wall thickness for evaluation of heart function2009

    • Author(s)
      Sato H, fukami T, Wu J, Thet-Thet-Lwin, Yuasa T, Takeda T, and Akatsuka T
    • Journal Title

      MI2008-135

  • [Journal Article] First experimental result with fluorescent X-ray CT based on sheet-beam geometry2009

    • Author(s)
      Huo Q, Sato H, Yuasa T, Akatsuka T, Wu J, Thet-Thet-Lwin, Takeda T, Hyodo K
    • DOI

      DOI:10.1002/xrs.1190

  • [Journal Article] 30-picoradian stabilization of optical components for X-ray interferometric imaging

    • Author(s)
      Yoneyama A, Takeya S, Ueda K, Hyodo K, Takeda T
    • Journal Title

      Photon Factory Activity Report

      Volume: 270

  • [Presentation] 分離型X線干渉計を用いた生体及び材料イメージングに関する研究2011

    • Author(s)
      武田徹、米山明男、上田和浩、竹谷敏、山田重人、兵藤一行
    • Organizer
      第28回PFシンポジウム
    • Place of Presentation
      つくば
    • Year and Date
      20110314-15
  • [Presentation] 分離型X線干渉計を用いた位相X線イメージングシステムの安定化2011

    • Author(s)
      米山明男、上田和浩、竹谷敏、兵藤一行、武田徹
    • Organizer
      第24回日本放射光学会
    • Place of Presentation
      つくば
    • Year and Date
      20110114-15
  • [Presentation] Comparison of chest dual-energy subtraction digital tomosynthesis and dual-energy subtraction radiography to detect simulated pulmonary nodules with and without calcifications : evaluation of phantom study2010

    • Author(s)
      Gomi T, Fujiwara H, Nakajima M, Umeda T, Okawa A, Takeda T, Sakaguchi K
    • Organizer
      RSNA 2010
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      20101200
  • [Presentation] Fluorescent X-ray computed tomography using synchrotron incident sheet-beam2010

    • Author(s)
      Yuasa T, Takeda T, Akatsuka T, Wu J
    • Organizer
      International Conference on Nanotechnology & Medical Sciences
    • Place of Presentation
      Kolhapur, INDIA
    • Year and Date
      20101021-23
  • [Presentation] X-ray imaging studies using synchrotron radiation2010

    • Author(s)
      Takeda T, Yoneyama A, Yuasa T, Akatsuka T, Wu J
    • Organizer
      International Conference on Nanotechnology & Medical Sciences
    • Place of Presentation
      Kolhapur, INDIA
    • Year and Date
      20101021-23
  • [Presentation] 位相X線撮影技術を用いた生体組織観察2010

    • Author(s)
      武田徹
    • Organizer
      第42回日本臨床分子形態学会総会
    • Place of Presentation
      静岡
    • Year and Date
      20100924-25
  • [Presentation] 生体試料観察のための位相及び蛍光X線イメージングの利用2009

    • Author(s)
      武田徹
    • Organizer
      第10回X線結像光学シンポジウム
    • Place of Presentation
      つくば
    • Year and Date
      20091106-07
  • [Presentation] 特徴点確率モデルに基づく曲面のレジストレーション2009

    • Author(s)
      渡辺航、本谷秀堅、武田徹、渡辺順久
    • Organizer
      28回日本医用画像工学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      20090805-06
  • [Book] Fluorescent X-ray computed tomography using synchrotron radiation towards molecular imaging2012

    • Author(s)
      Yuasa T, Takeda T
    • Total Pages
      39-70
    • Publisher
      InTech
  • [Book] Developmental anatomy of the human embryo-3D-imaging and analytical techniques2012

    • Author(s)
      Yamada S, Nakashima T, Hirose A, Yoneyama A, Takeda T. Takakuwa T
    • Total Pages
      111-126
    • Publisher
      InTech
  • [Book] Phase-contrast X-ray imaging with Bone-Hart type crystal X-ray interferometer handbook of interferometers, research, technology and applications.2009

    • Author(s)
      Takeda T, Yoneyama A, Halsey D. and Raynor W Takeya S, Thet-Thet-Lwin, Wu J
    • Total Pages
      218-316
    • Publisher
      Nova Science Publishers

URL: 

Published: 2013-07-31  

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