2011 Fiscal Year Final Research Report
Development of functional imaging method for effective cancer therapy
| Project/Area Number |
21390342
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | University of Fukui |
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Principal Investigator |
OKAZAWA Hidehiko 福井大学, 高エネルギー医学研究センター, 教授 (50360813)
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| Co-Investigator(Kenkyū-buntansha) |
KIYONO Yasushi 福井大学, 高エネルギー医学研究センター, 教授 (50305603)
MORI Tetsuya 福井大学, 高エネルギー医学研究センター, 助教 (40397287)
KUDO Takashi 長崎大学, 医歯薬学総合研究科, 教授 (20330300)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIOURA Hiroki 福井大学, 医学部, 講師 (50235488)
TSUJIKAWA Tetsuya 福井大学, 医学部, 助教 (30380033)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ポジトロンCT / 生体機能画像 / 低酸素 / 核酸代謝 / 受容体 |
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| Research Abstract |
We developed a new application method of functional PET imaging for treatment of advanced cancers based on the molecular imaging technique. Various aspects of tumor functions such as proliferation, hypoxia, receptor phenotype changes were delineated by the functional imaging methods. The tumor functional imaging provided useful information before treatment.
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Research Products
(77 results)
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[Journal Article] The use of nanoimprinted scaffolds as 3D culture models to facilitate spontaneous tumor cell migration and well-regulated spheroid formation2011
Author(s)
Yoshii Y, Waki A, Yoshida K, Kakezuka A, Kobayashi M, Namiki H, Kuroda Y, Kiyono Y, Yoshii H, Furukawa T, Asai T, Okazawa H, et al.
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Journal Title
Biomaterials
Volume: 32
Pages: 6052-6058
DOI
Peer Reviewed
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[Journal Article] Copper-64-diacetyl-bis(N4-methylthiosemicarbazone) accumulates in rich regions of CD133^+highly tumorigenic cells in mouse colon carcinom2010
Author(s)
Yoshii Y, Furukawa T, Kiyono Y, Watanabe R, Waki A, Mori T, Yoshii H, Oh M, Asai T, Okazawa H, et al.
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Journal Title
Nucl Med Biol
Volume: 37
Pages: 395-404
DOI
Peer Reviewed
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[Journal Article] Comparison of the transcellular transport of FDG and D-glucose by the kidney epithelial cell line, LLC-PK12010
Author(s)
Kobayashi M, Shikano N, Nishii R, Kiyono Y, Araki H, Nishi K, Oh M, Okudaira H, Ogura M, Yoshimoto M, Okazawa H, Fujibayashi Y, Kawai K.
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Journal Title
Nucl Med Commun
Volume: 31
Pages: 141-146
DOI
Peer Reviewed
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[Journal Article] Cytosolic acetyl-CoA synthetase affected tumor cell survival under hypoxia : the possible function in tumor acetyl-CoA/acetate metabolism2009
Author(s)
Yoshii Y, Furukawa T, Yoshii H, Mori T, Kiyono Y, Waki A, Kobayashi M, Tsujikawa T, Kudo T, Okazawa H, et al.
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Journal Title
Cancer Sci
Volume: 100
Pages: 821-827
DOI
Peer Reviewed
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