2011 Fiscal Year Final Research Report
Development of novel CT contrast agents with long retention in the vessel
| Project/Area Number |
21390343
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MAGATA Yasuhiro 浜松医科大学, メディカルフォトニクス研究センター, 教授 (20209399)
YAMAGUCHI Hiroshi 浜松医科大学, 光量子医学研究センター, 助教 (00450841)
FUCHIGAMI Takeshi 浜松医科大学, 光量子医学研究センター, 助教 (30432206)
OGAWA Mikako 浜松医科大学, メディカルフォトニクス研究センター, 准教授 (20344351)
KOJIMA Chie 大阪府立大学, 21世紀科学研究機構, 講師 (50405346)
SAKAI Toshihiro 浜松医科大学, メディカルフォトニクス研究センター, 特任研究員 (40585098)
TAKASHIMA Misato 浜松医科大学, メディカルフォトニクス研究センター, 助教 (70525592)
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| Project Period (FY) |
2009 – 2011
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| Keywords | X線 / 造影剤 |
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| Research Abstract |
The aim of this study is to develop novel CT contrast agent with a longer retention in blood in order to visualize vascular structure in a target tissue or angiogenesis of tumor. For this purpose, we use iodine or gold as a contrast element and human serum albumin or dendrimer modified with PEG as a carrier compound. Iodine modified agent showed a less enhancement effect in vivo because of its instability in blood. Gold modified agent showed a longer enhancement effect in vivo in comparison with a commercially available iodine contrast agent.
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