2011 Fiscal Year Final Research Report
Development of radiogallium-labeled agents for PET imaging without cyclotron
| Project/Area Number |
21390347
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kobe Pharmaceutical University (2011)
Kyushu University (2009-2010) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MAGATA Yasuhiro (20209399)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 放射性医薬品 / 造影剤 |
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| Research Abstract |
In this study, we designed DOTA-MN2 and DOTA-TZ2, employing metronidazole moiety as a recognition site of hypoxic tumors and Ac-TZ14011 peptide as a CXCR4 ligand, respectively. Radiogallium-DOTA-MN2 exhibited the high stability and significant accumulation in the hypoxic tumors. Ga-DOTA-TZ2 showed the high affinity to CXCR4 in vitro. These results provide useful information about the chemical design of radiogallium-labeled radiopharmaceuticals for PET studies.
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