2011 Fiscal Year Final Research Report
Imaging of neuroimmunoreactlve response-Multilateral validation uslng newly developed PBR ligands for positron emlssion computed tomography
| Project/Area Number |
21390350
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Fujita Health University |
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Principal Investigator |
TOYAMA Hiroshi 藤田保健衛生大学, 医学部, 准教授 (90247643)
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| Co-Investigator(Kenkyū-buntansha) |
HATANO Kentaro 国立長寿医療研究センター, 脳機能画像診断開発部, 室長 (50228475)
SAWADA Makoto 名古屋大学, 環境医学研究所, 教授 (10187297)
KUDO Gen 藤田保健衛生大学, 医学部, 講師 (20449466)
YAMADA Takashi 国立長寿医療研究センター, 脳機能画像診断開発部, 流動研究員 (50531860)
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| Research Collaborator |
NOMURA Masahiko 藤田保健衛生大学, 医学部, 大学院生
OTA Seiichiro 藤田保健衛生大学, 医学部, 大学院生
SUZUKI Hiromi 名古屋大学, 環境医学研究所, 助教
ICHISE Masanori コロンビア大学, 放射線科, 教授
TRAPANI Giuseppe Bari大学, 薬学部, 教授
WILSON Alan A. トロント大学, 医学部, 准教授
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| Project Period (FY) |
2009 – 2011
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| Keywords | 核医学(PETを含む) / 分子イメージング / ミクログリア / 末梢性ベンゾジアゼピン受容体(PBR)/輸送膜タンパク(TSPO) / 炎症性サイトカイン / チロシン水酸化酵素(TH) / 6-OHDA / リポポリサッカライド(LPS) |
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| Research Abstract |
Ncuro-reccpt on(peripheral benzodiazepine receptor : PBR/translocat or prat ein : TSPO) positron emission CT(PET) imaging and histological findings were compared in rat neuro-inflammat ion model under lipopolysaccharide(LPS) administration to ampli ry the inF1anmat. ion i n raperi onea 1 ly. Increased bindings of neuro-receptor(PBR/TSPO) PET imaging were shown under cytotoxic damage, act ivated gl i a cell(mi croglia) and increased expression of inflammatory cytokines. These results suggest. that. increased PBR/TSPO binding by PET appears a promising for early diagnosis of neuro-degenerative disorders.
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[Presentation] Detection of fully activated microglia with novel translocator protein(18kDa) ligand, [^<18> F] EEPPA PET2010
Author(s)
Toyama H, Kudo G, Hatano K, Suzuki H, Yamada T, Nomura M, Ichise M, Wilson AA, Sawada M
Organizer
2010 World Molecular Imaging Congress
Place of Presentation
Kyoto, Japan
Year and Date
20100908-11
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[Presentation] Correlation of FEPPA uptake and microglia activation in 6-OHDA injured rat brain2010
Author(s)
Hatano K, Yamada. T, Toyama H, Kudo G, Nomura M, Suzuki. H, Ichise M, Wilson AA, Sawada M, Kato T, Ito K
Organizer
Eighth International Mapping of the Living Brain(NRM2010)
Place of Presentation
Glasgow. UK
Year and Date
20100722-24
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[Presentation] Comparison of [^<18> F] FEPPA and [^<11> C] PBR28, novel peripheral benzodiazepine receptor ligands for PET, in a rat model of neuroinflammation2009
Author(s)
Toyama. H, Hatano K, Suzuki H, Kudo G, 1 chi se M, Wilson AA, Yamada T, Katada K, Sawada M, Ito K
Organizer
56^<th> Annual Meeting Society of Nuclear Medicine
Place of Presentation
Toronto, Canada
Year and Date
20090613-17
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