Adipocytokine is the new target of the strategy for the prevention of intimal hyperplasia

2011 Fiscal Year Final Research Report

• Project/Area Number: 21390357
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Nagoya University
• Principal Investigator: KOMORI Kimihiro 名古屋大学, 大学院・医学系研究科, 教授 (40225587)
• Co-Investigator(Kenkyū-buntansha): MUROHARA Toyoaki 名古屋大学, 大学院・医学系研究科, 教授 (90299503) ; SHIBATA Rei 名古屋大学, 大学院・医学系研究科, 特任講師 (70343689) ; YAMAMOTO Kiyohito 名古屋大学, 医学部附属病院, 講師 (10298359) ; KOBAYASHI Masayoshi 名古屋大学, 医学部附属病院, 助教 (60329381)
• Project Period (FY): 2009 – 2011
• Keywords: 脂肪細胞由来因子 / 血管内膜肥厚 / 自家静脈グラフト

Research Abstract

Pioglitazone attenuates intimal hyperplasia of the vein graft after autologous bypass grafting by its ability to suppress cell proliferation and enhance apoptosis. Pioglitazone could represent a therapeutic target for the prevention of graft failure after bypass grafting.

Research Products

• [Journal Article] Cost disparity between open repair and endovascular aneurysm repair for abdominal a ortic aneurysm (2012)
  • Author(s): Morimae H, Maekawa T, Tamai H, Takahashi N, Ihara T, Hori A, NaritaH, Banno H, Kobayashi M, Yamamoto K, Komori K
  • Journal Title: Japan Surg Today Volume: 42 Pages: 121-126
  • Peer Reviewed
• [Journal Article] Usefulness of POSSUM Physiological score for the Estimation of Morbidity and Mortality Risk after Elective Abdominal Aortic Aneurysm Repair in Japan (2011)
  • Author(s): Kodama A, Narita H, Kobayashi M, Yamamoto K, Komori K
  • Journal Title: Circulation J Volume: 75 Pages: 550-556
  • Peer Reviewed
• [Journal Article] Surgical experience of 13 infected in frarenal aortoiliac aneurysms (2011)
  • Author(s): Sugimoto M, Banno H, Idetsu A, Matsushita M, Ikezawa T, Komori K
  • Journal Title: Preoperative control of septic condition determines early outcome Surgery Volume: 149 Pages: 699-704
  • Peer Reviewed
• [Journal Article] Immunohistochemical properties in the patients with Buerger's disease-Possible role of Plasminogen Activator Inhibitor-1(PAI-1) for preservation of vessel wall architecture (2011)
  • Author(s): Sato T, Tamai H, Kobayashi M, Yamamoto K, Komori K
  • Journal Title: Cardiovascular Pathology Volume: 20 Pages: 266-271
  • Peer Reviewed
• [Journal Article] Pioglitazone prevents intimal hyperplasia in experimental rabbit vein graft. (2011)
  • Author(s): Morisaki K, Shibata R, TakahashiN, Ouchi N, Maehara Y, Murohara T, Komori K
  • Journal Title: J Vasc Surg Volume: 54(6) Pages: 1753-58
  • Peer Reviewed
• [Journal Article] Cilostazol Stimulates Revascularisation in Response to Ischaemia via an e NOS-Dependent Mechanism (2011)
  • Author(s): Hori A, Shibata R, Morisaki K, Murohara T, Komori K
  • Journal Title: Eur J Vasc Endovasc Surg Volume: 43 Pages: 62-65
  • Peer Reviewed
• [Journal Article] 喫煙によって閉塞性動脈疾患はどの程度悪化するのか (2011)
  • Author(s): 古森公浩
  • Journal Title: Heart View Volume: Vol.16 No.1 Pages: 53-57
• [Journal Article] A late type III endoleak from fabric tears of a Zenith stent graft A mosaic pattern of intrasac hematoma might be a serious finding (2011)
  • Author(s): Banno H, Morimae H, Ihara T, KobayashiM, Yamamoto K, Komori K
  • Journal Title: Surgery Today
  • Peer Reviewed
• [Journal Article] Mycotic aneurysm of the tibioperoneal trunk which precipitated acute compartment syndrome Report of a Case (2011)
  • Author(s): Sugimoto M, Komori K
  • Journal Title: Surg Today
  • Peer Reviewed
• [Journal Article] Evaluation of the Efficacy of Venous Thromboembolism (2010)
  • Author(s): Niimi K, Kobayashi M, Narita H, Yamamoto K, Komori K
  • Journal Title: Japan Surg Today Volume: 40 Pages: 1129-1136
  • Peer Reviewed
• [Journal Article] 腹部大動脈瘤手術 (2010)
  • Author(s): 古森公浩
  • Journal Title: 「手術」2月号 Volume: Vol.64No.2 Pages: 183-196
• [Journal Article] 末梢血管外科手術における再手術 (2010)
  • Author(s): 古森公浩
  • Journal Title: 日本心臓血管外科学会雑誌 Volume: Vol.39 No.2 Pages: 54-59
• [Journal Article] 末梢動脈再建術に愛用の手術器具・材料 (2010)
  • Author(s): 古森公浩
  • Journal Title: 臨床外科 Volume: Vol.65 No.7 Pages: 929-933
• [Journal Article] Sarpogrelate hydrochloride reduced intimal hyperplasia in experimental rabbit vein graft J Vasc Surg (2009)
  • Author(s): Kodama A, Komori K, Hattori K, Yamanouchi D, Kajikuri J, Itoh T
  • Journal Title: J Vasc Surg Volume: 49 Pages: 1272-81
  • Peer Reviewed
• [Journal Article] Chronic treatment of hydroxytryptamine type 2a receptor antagonist sarpogrelate hydrochloride modulates the vasoreactivity of serotonin in experimental rabbit vein grafts (2009)
  • Author(s): Kodama A, Komori K, Kajikuri J, Itoh T
  • Journal Title: J Vasc Surg Volume: 50 Pages: 617-25
  • Peer Reviewed
• [Presentation] Buerger病罹患動脈壁におけるNotchシグナルの発現について (2011)
  • Author(s): 玉井宏明、森崎浩一、宮地紘樹、前川卓史、高橋範子、渡辺芳雄、森前博文、井原努、堀昭彦、坂野比呂志、小林昌義、山本清人、古森公浩
  • Organizer: 第111回日本外科学会定期学術集会
  • Year and Date: 20110526-28
• [Presentation] ピオグリタゾンによる静脈グラフト内膜肥厚抑制効果の検討 (2011)
  • Author(s): 森崎浩一、前川卓史、玉井宏明、高橋範子、渡辺芳雄、森前博文、井原努、堀昭彦、坂野比呂志、小林昌義、山本清人、古森公浩
  • Organizer: 第111回日本外科学会定期学術集会
  • Year and Date: 20110526-28
• [Presentation] そけい靭帯以下の動脈病変に対するEVTの展望～TASCIIBを控えて～ (2011)
  • Author(s): 古森公浩
  • Organizer: 第4回九州Joint Endovascular Therapeutics(The 4th QJET)
  • Place of Presentation: 小倉記念病院講堂北九州市
  • Year and Date: 2011-10-15
• [Presentation] Current status of the therapeutic strategy in the patients with peripheral arterial disease (2011)
  • Author(s): Komori K
  • Organizer: 第43回日本動脈硬化学会総会・学術集会
  • Place of Presentation: ロントン札幌
  • Year and Date: 2011-07-16
• [Presentation] 血管病治療の最前線 (2011)
  • Author(s): 古森公浩
  • Organizer: 第25回日本血管外科学会近畿地方会
  • Place of Presentation: 和歌山県立医科大学高度医療人育成センター5F
  • Year and Date: 2011-03-12
• [Presentation] 遠隔成績を考慮した間歇性跛行肢の治療選択」当科での間歇性跛行肢に対する血行再建術の検討 (2011)
  • Author(s): 森崎浩一、前川卓史、玉井宏明、高橋範子、渡辺芳雄、森前博文、井原努、堀昭彦、坂野比呂志、小林昌義、山本清人、古森公浩
  • Organizer: 第41回日本心臓血管外科学会
  • Place of Presentation: 東京ベイ舞浜ホテルクラブリゾート
  • Year and Date: 2011-02-24
• [Presentation] 血管内膜肥厚とミッドカインの関連について (2010)
  • Author(s): 坂野比呂志、森崎浩一、玉井宏明、高橋範子、渡辺芳雄、森前博文、井原努、堀昭彦、小林昌義、山本清人、古森公浩
  • Organizer: 第51回日本脈管学会総会
  • Place of Presentation: 旭川グランドホテル北海道
  • Year and Date: 20101014-16
• [Presentation] Endothelium, nitric oxide and vein grafts (2010)
  • Author(s): Komori K
  • Organizer: Fourth Scientific Meeting Asian Society for Vascular Biology
  • Place of Presentation: Cheung Kung Hai Conference Centre, Hong Kong, China
  • Year and Date: 2010-11-21
• [Presentation] Pioglitazone Prevents Intimal Hyperplasia In Experimental Rabbit Vein Graft (2010)
  • Author(s): Morisaki K, Shibata R, Banno H, Kobayashi M, Yamamoto K, Murohara T, Komori K
  • Organizer: American Heart Association Scientific Sessions 2010
  • Place of Presentation: McCormick Place, Chicago, IL, USA
  • Year and Date: 2010-11-17
• [Presentation] Current Status of Therapeutic Angiogenesis for the Patients with Peripheral Arterial Disease in Japan (2010)
  • Author(s): Komori K
  • Organizer: The 4th Annual Meeting of World Federation of Vascular Societies The 5th Asian Venous Forum
  • Place of Presentation: The Westin Miyako, Kyoto
  • Year and Date: 2010-06-30
• [Presentation] Differences in the Endothelial Function and Morphological Modulation between the Canine Autogenous Vein and Arterial Grafts Endothelium andIntimal Thickening (2010)
  • Author(s): Komori K
  • Organizer: The 6th International Conference onthe Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Kyoto International
  • Year and Date: 2010-06-16
• [Presentation] Cilostazol Causes Angiogenesis Mediated through the Enhancement of Nitric Oxide Production in the Ischemic Hind limb of Mouse (2010)
  • Author(s): Hori A, Shibata R, Narita H, KobayashiM, Yamamoto K, Komori K
  • Organizer: 2010 Vascular Annual Meeting
  • Place of Presentation: Hynes Convention Center, Boston, Massachusetts, USA
  • Year and Date: 2010-06-11
• [Presentation] 血管外科領域におけるトランスレーショナルリサーチ. Nitric Oxideとセロトニン- (2010)
  • Author(s): 古森公浩
  • Organizer: 第38回日本血管外科学会総会
  • Place of Presentation: 大宮ソニックシティ・パレスホテル大宮
  • Year and Date: 2010-05-21
• [Presentation] IFU(Instruction For Use)外に施行した腹部大動脈瘤ステントグラフト内挿術の検討 (2010)
  • Author(s): 井原努、森崎浩一、玉井宏明、前川卓史、高橋範子、森前博文、堀昭彦、成田裕司、小林昌義、山本清人、古森公浩
  • Organizer: 第38回日本血管外科学会総会
  • Place of Presentation: 大宮ソニックシティ・パレスホテル大宮
  • Year and Date: 2010-05-21
• [Presentation] 教育講演「日常診療に役立つ脈管診療の実際」「動脈・静脈疾患外科治療の現況」.血管内治療か?外科治療か? (2010)
  • Author(s): 古森公浩
  • Organizer: The 27rd Live Demonstration in KOKURA
  • Place of Presentation: 北九州
  • Year and Date: 2010-05-16
• [Presentation] ヨードアレルギー・腎機能障害症例に対する炭酸ガス血管造影の有用性 (2010)
  • Author(s): 森崎浩一、前川卓史、玉井宏明、高橋範子、森前博文、井原努、堀昭彦、成田裕司、小林昌義、山本清人、古森公浩
  • Organizer: 第110回日本外科学会定期学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-04-09
• [Presentation] THERAPEUTIC ANGIOGENESIS FOR THEPATIENTS WITH PERIPHERAL ARTERIALDISEASE (2009)
  • Author(s): Komori K
  • Organizer: The 10th Annual Congress of AsianSociety for Vascular Surgery
  • Place of Presentation: BEXCO, Busan, Korea
  • Year and Date: 2009-10-16
• [Presentation] Differences in the Endothelial Function and Morphological Modulation between the Canine Autogenous Vein and Arterial Grafts (2009)
  • Author(s): Komori K
  • Organizer: Satellite Symposium of the IUPS2009
  • Place of Presentation: Nagoya City University Hospital Nagoya
  • Year and Date: 2009-07-25
• [Presentation] SARPOGRELATE HYDROCHLORIDE MODULATES THE EXPRESSION OF 5-HYDROXYTRYPTAMINE TYPE 2A AND TYPE 1B RECEPTORS IN EXPERIMENTAL RABBIT VEIN GRAFTS (2009)
  • Author(s): Kodama A, Tamai H, Idetsu A, Morimae H, Hori A, Narita H, Kobayashi M, Yamamoto K, Kajikuri J, Itoh T, Komori K
  • Organizer: 10th MOVD 2009, 10th International Symposium on Mechanisms of Vasodilatation
  • Place of Presentation: Matsushima, Miyagi
  • Year and Date: 2009-06-03
• [Presentation] Sarpogrelate Hydrochloride Modulates the Expression of 5-HydroxytryptamineType 2A and Type 1B Receptors in Experimental Rabbit Vein Grafts (2009)
  • Author(s): Kodama A, Tamai H, Idetsu A, Morimae H, Hori A, Narita H, Kobayashi M, Yamamoto K, Komori K
  • Organizer: Arteriosclerosis, Thrombosis and Vascular Biology Annual Conference2009
  • Place of Presentation: Washington
  • Year and Date: 2009-05-01
• [Presentation] 卒業教育セミナー末梢血管外科手術における再手術 (2009)
  • Author(s): 古森公浩
  • Organizer: 第39回日本心臓血管外科学会学術総会
  • Place of Presentation: 富山国際会議場
  • Year and Date: 2009-04-21
• [Presentation] 総腸骨動脈瘤を合併した腹部大動脈瘤に対するステントグラフト内挿術の治療戦略 (2009)
  • Author(s): 出津明仁、玉井宏明、森前博文、児玉章朗、堀昭彦、成田裕司、小林昌義、山本清人、古森公浩
  • Organizer: 第109回日本外科学会定期学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2009-04-03
• [Book] 今日の診療指針 (2011)
  • Author(s): 古森公浩
  • Total Pages: 21-34
  • Publisher: 医学書院
• [Book] 今日の心臓手術の適応と至適時期 (2011)
  • Author(s): 古森公浩
  • Total Pages: 322-324
  • Publisher: 文光堂
• [Remarks] ホームページ
  • URL: http://www.med.nagoya-u.ac.jp/medical/1766/1778/kekkangekagaku
• [Remarks] 名古屋大学医学部・大学院医学系研究科血管外科学(第一外科)
  • URL: http://www.vascsurg.j
• [Remarks] 名古屋大学血管外科