2011 Fiscal Year Final Research Report
Integrated research for respective role of cancer and microenvironment towards clinical application
| Project/Area Number |
21390360
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORI Masaki 大阪大学, 医学系・研究科, 教授 (70190999)
AKAIKE Toshihiro 東京工業大学, 生命理工学部, 教授 (30101207)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 癌 / 微小環境 / 浸潤 / 転移 |
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| Research Abstract |
(1) We reported OSNA-based diagnosis of lymph node metastasis of colorectal cancer in 2010, and Ministry of Health, Labour and Welfare permitted its usage in diagnosis.(2) We produced the C4. 4A specific antibody that recognizes only invasive cancer cells. We also found that C4. 4A promotes EMT.(3) We found that hypoxia-induced gene JMJD1A promotes EMT in colon cancer.(4) We found that carbonate apatite containing specific siRNA showed a tumor shrinkage when it is injected into the tail vein of nude mice.(5) We found inhibition of both VEGF and Ang2 led to a tumor shrinkage in nude mice.
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