Novel therapy for aortic aneurysms by targeting a mechanical stress sensor

2011 Fiscal Year Final Research Report

• Project/Area Number: 21390362
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Yamaguchi University
• Principal Investigator: YOSHIMURA Koichi 山口大学, 大学院・医学系研究科, 准教授(特命) (00322248)
• Co-Investigator(Kenkyū-buntansha): AOKI Hiroki 久留米大学, 循環器病研究所, 准教授 (60322244) ; IKEDA Yasuhiro 山口大学, 大学院・医学系研究科, 助教 (00260349)
• Co-Investigator(Renkei-kenkyūsha): TAKAHASHI Masafumi 自治医科大学, 医学部, 教授 (40296108) ; TANIGUCHI Shun' ichiro 信州大学, 大学院・医学系研究科, 教授 (60117166)
• Project Period (FY): 2009 – 2011
• Keywords: 大動脈瘤 / メカニカルストレス / 炎症

Research Abstract

Abdominal aortic aneurysm(AAA) is characterized by chronic inflammation. Although a mechanical stress may contribute to pathogenesis of AAA, the mechanism that connects mechanical stress to inflammation is not yet understood. In this study, we demonstrated that the mechanical stress caused the activation of inflammatory signaling molecule and the release of inflammatory cytokine in macrophages. In addition, our data suggested that ASC might be critical for the linkage between mechanical stress and inflammatory response.

Research Products

• [Journal Article] 大動脈瘤とテネイシンC (2011)
  • Author(s): 吉村耕一, 木村泰三, 青木浩樹
  • Journal Title: 呼吸と循環 Volume: 59(11) Pages: 1107-1113
• [Journal Article] InnocentBystander? Intraluminal Thrombus in Abdominal Aortic Aneurysm (2011)
  • Author(s): Yoshimura K, Ikeda Y, Aoki H
  • Journal Title: Atherosclerosis Volume: 218(2) Pages: 285-286
  • Peer Reviewed
• [Journal Article] Tenascin-C is expressed in abdominal aortic aneurysm tissue with active degradation process (2011)
  • Author(s): Kimura T, Yoshimura K, Aoki H, Imanaka-Yoshida K, Yoshida T, Ikeda Y, Morikage N, Endo H, Hamano K, Imaizumi T, Hiroe M, Aonuma K, Matsuzaki M
  • Journal Title: Pathol Int Volume: 61 Pages: 559-564
  • Peer Reviewed
• [Journal Article] 慢性炎症と大動脈瘤 (2011)
  • Author(s): 青木浩樹, 吉村耕一
  • Journal Title: 呼吸と循環 Volume: 59(9) Pages: 883-889
• [Journal Article] 大動脈瘤の分子病態 (2011)
  • Author(s): 吉村耕一, 長澤綾子, 山下修, 濱野公一
  • Journal Title: 最新医学 Volume: 66(7) Pages: 1628-1633
• [Journal Article] 大動脈瘤-慢性炎症のモデル疾患 (2011)
  • Author(s): 青木浩樹, 吉村耕一
  • Journal Title: 医学のあゆみ Volume: 236(4) Pages: 271-277
• [Journal Article] 大動脈瘤/大動脈解離の薬物療法 (2010)
  • Author(s): 吉村耕一, 森景則保, 青木浩樹
  • Journal Title: Vascular Lab Volume: 7(6) Pages: 48-52
• [Journal Article] 大動脈瘤の非手術治療は可能か (2010)
  • Author(s): 吉村耕一
  • Journal Title: Heart View Volume: 14(9) Pages: 94-97
• [Journal Article] 1) JNK活性化と大動脈疾患 (2010)
  • Author(s): 吉村耕一, 青木浩樹, 濱野公一, 松崎益徳
  • Journal Title: 特集「大動脈疾患-大動脈解離と胸腹部大動脈瘤:診断と治療の進歩」日本内科学会雑誌 Volume: 99(2) Pages: 19-26
• [Journal Article] Lysyl oxidase resolvesinflammation by reducing monocyte chemoattractant protein-1 in abdominal aortic aneurysm (2010)
  • Author(s): Onoda M, Yoshimura K, Aoki H, Ikeda Y, Morikage N, Furutani A, Matsuzaki M, Hamano K
  • Journal Title: Atherosclerosis Volume: 208(2) Pages: 366-369
  • Peer Reviewed
• [Journal Article] 特集「大動脈瘤の分子細胞生物学」1.臨床と基礎の接点 (2009)
  • Author(s): 吉村耕一, 青木浩樹, 小櫃由樹生, 重松宏, 松崎益徳
  • Journal Title: 血管医学 Volume: 10(3) Pages: 13-19
• [Journal Article] INTERFACE基礎動脈瘤の病態生理 (2009)
  • Author(s): 吉村耕一, 青木浩樹, 木村泰三, 松崎益徳
  • Journal Title: International Review of Thrombosis Volume: 4(2) Pages: 90-95
• [Presentation] Involvement of JNK2 in Mechanosensing and Proinflammatory Signaling during Development of Aortic Aneurysm (2011)
  • Author(s): Yoshimura K
  • Organizer: The Scientific Conference" Abdominal Aortic Aneurysm : Epidemiology, Genetics, and Pathophysiology
  • Place of Presentation: Danville, PA, U. S. A.
  • Year and Date: 20111020-22
• [Presentation] Molecular Pathogenesis of AAA. Invited lecture (2010)
  • Author(s): Yoshimura K
  • Organizer: 2nd International Meeting on Aortic Disease-New insights into an old problem-
  • Place of Presentation: Liege, Belgium
  • Year and Date: 20100930-1002
• [Presentation] Tenascin C Protects Aortic Tissue From Multiple Insults Against The Development of Aortic Aneurysm (2009)
  • Author(s): Aoki H, Kimura T, Yoshimura K, Imanaka-Yoshida K, Yoshida T, Aonuma K, Hiroe M, Imaizumi Y, Matsuzaki M
  • Organizer: 49th American Society for Cell Biology Annual Meeting
  • Place of Presentation: San Diego, CA, U. S. A.
  • Year and Date: 20091205-09
• [Presentation] Critical role of JNK2 for development of abdominal aortic aneurysm in a murine model. Best Scientific Paper Award (2009)
  • Author(s): Yoshimura K, Aoki H, Furutani A, Matsuzaki M, Hamano K
  • Organizer: The 6th Korea-Japan Joint Meeting for Vascular Surgery
  • Place of Presentation: Busan, Korea
  • Year and Date: 2009-10-14
• [Book] 第3節大動脈瘤モデル.疾患モデルの作製と利用-循環器疾患 (2010)
  • Author(s): 吉村耕一, 青木浩樹
  • Total Pages: 149-160
  • Publisher: エル・アイ・シー
• [Book] 大動脈瘤研究の現状と課題.循環器疾患のサイエンス (2010)
  • Author(s): 青木浩樹, 吉村耕一
  • Total Pages: 171-180
  • Publisher: 南山堂
• [Book] Regression of Abdominal Aortic Aneurysms through Pharmacologic Therapy. In" Advances in Understanding Aortic Diseases" (2009)
  • Author(s): Yoshimura K, Aoki H, Ikeda Y, Furutani A, Hamano K, Matsuzaki M
  • Total Pages: 43-49
  • Publisher: Springer Japan