Systematic analysis of angiogenesis system and development of novel immunomodulation in organ acceptance and regeneration

2012 Fiscal Year Final Research Report

• Project/Area Number: 21390366
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Nara Medical University
• Principal Investigator: NAKAJIMA Yoshiyuki 奈良県立医科大学, 医学部, 教授 (00142381)
• Co-Investigator(Kenkyū-buntansha): SHO Masayuki 奈良県立医科大学, 医学部, 准教授 (50364063)
• Project Period (FY): 2009 – 2012
• Keywords: 臓器移植 / 拒絶反応 / 血管新生

Research Abstract

The aim of this study was to clarify unknown mechanisms relating to angiogenesis in graft acceptance and tissue regeneration. Moreover, we aimed to develop novel therapeutic strategy inducing durable immunoregulation and long-term acceptance in organ and cell transplantation. We found that TWEAK/Fn14 pathway plays a critical role in ischemia-reperfusion injury. Importantly, Fn14 blockade had a significant inhibitory effect on inhibition of injury. In inflammatory bowel disease model, we うい erythropoietin, which has a proangiogenic property, was found to not only prevent tissue injury, but also accelerate tissue repair. These revealed mechanisms may lead to develop novel therapeutic strategy for intractable disease conditions.

Research Products

• [Journal Article] Simultaneous blockade of programmed death 1 and vascular endothelial growth factor receptor 2 (VEGFR2) induces synergistic anti-tumour effect in vivo (2013)
  • Author(s): Yasuda S, Sho M, Yamato I, Yoshiji H, Wakatsuki K, Nishiwada S, Yagita H, Nakajima Y
  • Journal Title: Clin Exp Immunol Volume: 172(3) Pages: 500-6
  • Peer Reviewed
• [Journal Article] PCA-1/ALKBH3 contributes to pancreatic cancer by supporting apoptotic resistance and angiogenesis (2012)
  • Author(s): Yamato I, Sho M, Shimada K, Hotta K, Ueda Y, Yasuda S, Shigi N, Konishi N, Tsujikawa K, Nakajima Y
  • Journal Title: Cancer Res Volume: 72 (18) Pages: 4829-39
  • Peer Reviewed
• [Journal Article] Direct targeting of fibroblast growth factor-inducible 14 protein protects against renal ischemia reperfusion injury (2011)
  • Author(s): Hotta K, Sho M, Yamato I, Shimada K, Harada H, Akahori T, Nakamura S, Konishi N, Yagita H, Nonomura K, Nakajima Y
  • Journal Title: Kidney Int Volume: 79(2) Pages: 179-88
  • Peer Reviewed
• [Journal Article] Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer (2011)
  • Author(s): Yoriki R, Akashi S, Sho M, Nomi T, Yamato I, Hotta K, Takayama T, Matsumoto S, Wakatsuki K, Migita K, Yagita H, Nakajima Y
  • Journal Title: Exp Ther Med Volume: 2(1) Pages: 103-108
  • Peer Reviewed
• [Presentation] 膵癌における T 細胞 Negative Pathway の意義と新規癌免疫治療の可能性 (2013)
  • Author(s): 庄 雅之
  • Organizer: 第113回日本外科学会定期学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20130411-13
• [Presentation] 膵癌における PCA-1/ALKBH3 の役割と新規治療の可能性 (2013)
  • Author(s): 山戸一郎
  • Organizer: 第113回日本外科学会定期学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20130411-13
• [Presentation] Direct targeting of fibroblast growth factor-inducible 14 protein protects against renal ischemia reperfusion injury (2012)
  • Author(s): 堀田記世彦
  • Organizer: 第7回日本移植学会賞 受賞講演.第48回日本移植学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 20120920-22
• [Presentation] Simultaneous blockade of PD-1 and VEGFR2 induces synergistic antitumor effect (2012)
  • Author(s): 安田里司
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 20120919-21
• [Presentation] 腎虚血再灌流障害におけるTWEAK受容体Fn14の関与と新規治療戦略の可能性 (2010)
  • Author(s): 堀田記世彦
  • Organizer: 日本泌尿器科学会総会賞受賞.第98回日本泌尿器科学会総会
  • Place of Presentation: 盛岡
  • Year and Date: 20100427-30
• [Presentation] 腎虚血再灌流障害におけるTWEAK/Fn14経路の役割 (2009)
  • Author(s): 堀田記世彦
  • Organizer: 第45回日本移植学会総会
  • Place of Presentation: 東京
  • Year and Date: 20090916-18