2011 Fiscal Year Final Research Report
Novel therapeutic strategy for aortic aneurysm targeting master cytokine and cellular senescence
| Project/Area Number |
21390367
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kurume University |
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Principal Investigator |
AOKI Hiroki 久留米大学, 循環器病研究所, 教授 (60322244)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMURA Koichi 山口大学, 大学院・医学系研究科, 准教授 (00322248)
YASUKAWA Hideo 久留米大学, 医学部, 准教授 (60289361)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 循環器・高血圧 / 細胞・組織 / シグナル伝達 / トランスレーショナルリサーチ |
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| Research Abstract |
Abdominal aortic aneurysm(AAA) is common to eldery people, of which molecula pathogenesis is largely unknown. We hypothesized that IL-6 may be the master cytokine for regulating the chronic inflammation and tissue destruction in AAA. Indeed, IL-6 was one of the most abundantly expressed cytokines and regulating a subset of proinflammatory cytokines, including VEGF and MCP-3, in human AAA tissue. In mouse model of AAA, IL-6 expression was associated with the expansion of aortic diameter, and was involved in the progression of AAA. Although macrophages are important in pathogenesis of AAA, enhanced IL-6 signaling in macrophages did not affect AAA development. Thus, IL-6-dependent development of AAA appeared to be mediated by cell types other than macrophages. Unexpectedly, we discovered that macrophage IL-6 signaling was critically involved in the development of acute aortic dissection. In the future studies, we will address which cell type is responsible for the IL-6-dependent devopment of AAA, and how macrophage IL-6 is involved in the pathogenesis of aortic dissection.
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[Presentation] Tenascin-C Is a Molecular Shock-Absorber That Protects Aorta from Dissection2010
Author(s)
H. Aoki, T. Kimura, K. Yoshimura, K. Imanaka-Yoshida, T. Yoshida, K. Aonuma, M. Hiroe, T. Imaizumi, M. Matsuzaki
Organizer
American Society for Cell Biology Annual Meeting 2010
Place of Presentation
Philadelphia, PA, USA
Year and Date
20101211-15
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[Presentation] ワークショップ「慢性炎症:生活習慣病・癌に共通する基盤病態」炎症のタイムカプセル:大動脈瘤をモデル疾患とした慢性炎症の病態解明2009
Author(s)
青木浩樹, 吉村耕一, 木村泰三, 宮本貴宣, 今中-吉田恭子, 吉田利通, 浜本義彦, 青沼和隆, 廣江道昭, 重松宏, 松崎益徳, 今泉勉
Organizer
第32回日本分子生物学会
Place of Presentation
横浜
Year and Date
20091209-12
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[Presentation] Tenascin-C Has A Protective Role during The Development of Aortic Aneurysm2009
Author(s)
Kimura T, Yoshimura K, Aoki H, Ikeda Y, Hamano K, Imanaka-Yoshida K, Yoshida T, Hiroe M, Aonuma K and Matsuzaki M
Organizer
American Heart Association Scientific Sessions 2009
Place of Presentation
Orlando, FL, USA
Year and Date
20091114-18
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