2011 Fiscal Year Final Research Report
Prospective isolation of pancreatic cancer cells with highly malignant phenotype and development of future individualized therapy
| Project/Area Number |
21390381
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
TANAKA Masao 九州大学, 医学研究院, 教授 (30163570)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Norihiro 九州大学, 大学院・医学研究院, 共同研員 (20423527)
OHUCHIDA Kenoki 九州大学, 大学院・医学研究院, 講師 (20452708)
TOMA Hiroki 九州大学, 大学病院, 講師 (80437780)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 膵臓外科学 / 膵癌 / セルソーティング / 癌間質相互作用 / 上皮間葉移行(EMT) |
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| Research Abstract |
We identified CD133 positive pancreatic cancer cells with high malignant potential. CD133 positive pancreatic cancer cells have strong invasive ability via SDF1-CXCR4 pathway. We also found that migration of CD105 positive pancreatic cancer cells was promoted by cancer-stromal interactions. Moreover, we clarified that collagen-internalization receptor CD280 was an important molecule for invasion of pancreatic cancer cells. We reduced the invasion of pancreatic cancer cells by knockdown of CD280. In the present study, we identified several molecules as promising therapeutic targets.
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Research Products
(16 results)
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[Journal Article] High EGFR mRNA Expression Level is a Prognostic Factor for Reduced Survival in Pancreatic Cancer after Gemcitabine-based Adjuvant Chemotherapy International Journal of Oncology2011
Author(s)
Hayato Fujita, Kenoki Ohuchida, Kazuhiro Mizumoto, Soichi Itaba, Tetsuhide Ito, Kohei Nakata, Jun Yu, Tadashi Kayashima, Akifumi Hayashi, Ryota Souzaki, Tatsuro Tajiri, Manabu Onimaru, Tatsuya Manabe, Takao Ohtsuka, Masao Tanaka
Volume
38
Pages
629-41
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