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2011 Fiscal Year Final Research Report

Investigation of clinical significance of lymph node micro metastasis in gastro intestinal cancer.

Research Project

  • PDF
Project/Area Number 21390382
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKagoshima University

Principal Investigator

NATSUGOE Shoji  鹿児島大学, 医歯学総合研究科, 教授 (70237577)

Co-Investigator(Kenkyū-buntansha) ISHIGAMI Sumiya  鹿児島大学, 医学部・歯学部附属病院, 講師 (90325803)
MATSUMOTO Masataka  鹿児島大学, 大学院・医歯学総合研究科, 客員 (40398293)
KIJIMA Yuko  鹿児島大学, 医学部・歯学部附属病院, 助教 (60381175)
UENOSONO Yoshikazu  鹿児島大学, 大学院・医歯学総合研究科, 特任准教授 (60398279)
UCHIKADO Yasuto  鹿児島大学, 医学部・歯学部附属病院, 助教 (30464465)
Project Period (FY) 2009 – 2011
Keywordsリンパ節転移 / 微小転移 / サイトケラチン染色 / RT-PCR / Gene Search System / センチネルリンパ節 / ケモカイン / リンパ管新生
Research Abstract

In the clinical significance of lymph node micrometastasis(LMM), LMM was examined by immunostaining and RT-PCR. The diagnosis of LMM is clinically useful for less invasive surgery such as sentinel node navigation surgery. Some genes related with lymph node metastasis were found by microaaray method. Such genes correlated well with clinical samples of gastrointestinal cancer. Preoperative chemo-radiation therapy was effective for LMM in esophageal cancer. The factors of lymphangiogenesis and chemokines were important for the formation and growth of LMM. In experimental study, a few cancer cells had growth ability and such result may offer important information for cancer treatment.

  • Research Products

    (22 results)

All 2011 2010 2009

All Journal Article (12 results) (of which Peer Reviewed: 10 results) Presentation (10 results)

  • [Journal Article] Sentinel node navigation surgery is acceptable for clinical T1 and N0 esophageal cancer2011

    • Author(s)
      Uenosono Y, Natsugoe S.
    • Journal Title

      Ann Surg Oncol

      Volume: 18 Pages: 2003-2009

    • Peer Reviewed
  • [Journal Article] Prognostic impact of CD168 expression in gastric cancer2011

    • Author(s)
      Ishigami S, Natsugoe S.
    • Journal Title

      BMC Cancer

      Volume: 24 Pages: 106-110

    • Peer Reviewed
  • [Journal Article] Neoadjuvant chemoradiotherapy for advanced esophageal cancer2011

    • Author(s)
      Natsugoe S.
    • Journal Title

      Nihon Geka Gakkai Zasshi

      Volume: 112 Pages: 111-116

  • [Journal Article] From uniformed treatment to individualized treatment for superficial esophageal cancer-what is potentially a new approach?2010

    • Author(s)
      Natsugoe S.
    • Journal Title

      Ann Thorac Cardiovasc Surg

      Volume: 16 Pages: 1-3

  • [Journal Article] Utility of the GeneSearch breast lymph node assay for the rapid evaluation of sentinel lymph nodes in breast cancer2010

    • Author(s)
      Funasako Y, Natsugoe S.
    • Journal Title

      Cancer

      Volume: 116 Pages: 4450-4455

    • Peer Reviewed
  • [Journal Article] Expression of B7-H4 in blood of patients with gastric cancer predicts tumor progression and prognosis2010

    • Author(s)
      Arigami T, Natsugoe S.
    • Journal Title

      Journal of Surgical Oncology

      Volume: 102 Pages: 748-752

    • Peer Reviewed
  • [Journal Article] Clinical course and outcome after esophageactomy with three-field lymphadenectomyin esophageal cancer2010

    • Author(s)
      Natsugoe S, Matsumoto M.
    • Journal Title

      Langenbecks Arch Surg

      Volume: 395 Pages: 341-346

    • Peer Reviewed
  • [Journal Article] Prognostic impact of Cd133 expression in gastric carcinoma2010

    • Author(s)
      Ishigami S, Natsugoe S.
    • Journal Title

      Anticancer Res

      Volume: 30 Pages: 5175-5180

    • Peer Reviewed
  • [Journal Article] Nuclear expression of 14-3-3 sigma is related to prognosis in patients with esophageal squamous cell carcinoma2010

    • Author(s)
      Okumura H, Natsugoe S.
    • Journal Title

      Anticancer Res

      Volume: 30 Pages: 5175-5180

    • Peer Reviewed
  • [Journal Article] Vascular endothelialgrowth factor-C and-D expression correlates with lymph node micrometastasis in pN0 early gastric cancer2009

    • Author(s)
      Arigami T, Natsugoe S.
    • Journal Title

      Journal of Surgical Oncology

      Volume: 99 Pages: 148-153

    • Peer Reviewed
  • [Journal Article] CCR7 and CXCR4 expression predicts lymph node status including micrometastasis in gastric cancer2009

    • Author(s)
      Arigami T, Natsugoe S.
    • Journal Title

      International Journal of Oncology

      Volume: 35 Pages: 19-24

    • Peer Reviewed
  • [Journal Article] The utility of rapid diagnosis of lymph node metstasis in gastric cancer using a multiplex real-time RT-PCR assay2009

    • Author(s)
      Yanagita S, Natsugoe S.
    • Journal Title

      Oncology

      Volume: 77 Pages: 205-211

    • Peer Reviewed
  • [Presentation] Current Status and Future Perspective of Sentinel Node Navigation Surgery for Gastrointestinal Cancer2011

    • Author(s)
      Natsugoe S.
    • Organizer
      The International Association of Surgeons, Gastroenterologists and Oncologists
    • Place of Presentation
      Tokyo
    • Year and Date
      2011-11-11
  • [Presentation] Clinical significance of isolated tumor cells in esophageal and gastric cancer2011

    • Author(s)
      Natsugoe S.
    • Organizer
      8^<th> International Symposium on Minimal Residual Cancer Symposium
    • Place of Presentation
      Osaka
    • Year and Date
      2011-09-22
  • [Presentation] Minimally invasive treatment for adenocarcinoma of esophago-gastric junction2011

    • Author(s)
      Natsugoe S.
    • Organizer
      International Surgical Week
    • Place of Presentation
      Yokohama
    • Year and Date
      2011-08-30
  • [Presentation] Assay as an Intr aoperative Diagnostic Tool for Sentinel Lymph Nodes in Patients with Breast an d Gastric Cancer2010

    • Author(s)
      Natsugoe S.
    • Organizer
      The 7^<th> International Sentinel Node Society Meeting
    • Place of Presentation
      Yokohama
    • Year and Date
      2010-11-18
  • [Presentation] The Development of RT-PCR Assay as an Intraoperative Diagnostic Tool for Sentinel Lymph Nodes in Patients with Breast and Gastric Cancer2010

    • Author(s)
      Natsugoe S.
    • Organizer
      The 7^<th> International Sentinel Node Society Meeting
    • Place of Presentation
      Yokohama
    • Year and Date
      2010-11-18
  • [Presentation] The Clinical Utility of Laparoscopic Gastrectomy Based on Sentinel Node Concept in Patients With Early Gastric Cancer2010

    • Author(s)
      Natsugoe S.
    • Organizer
      The 7^<th> International Sentinel Node Society Meeting
    • Place of Presentation
      Yokohama
    • Year and Date
      2010-11-18
  • [Presentation] Assessment of ly 6ph node metastasis in esophageal cance r using ultrasound and endoscopic ultra sound2010

    • Author(s)
      Natsugoe S.
    • Organizer
      The 12^<th> World Congress of Intern ational Society for Disease of the Esop hagus
    • Place of Presentation
      Kagoshima
    • Year and Date
      2010-09-05
  • [Presentation] Expression of B7-H4 in blood of patients with gastric cancer predicts tumor progression and prognosis2010

    • Author(s)
      Natsugoe S.
    • Organizer
      The 9^<th> International Conference of The Asian Clinical Oncology Society
    • Place of Presentation
      Gifu
    • Year and Date
      2010-08-25
  • [Presentation] Current Status and Future 7erspective of Sentinel Node Navigation Surgery for Gastric Cancer2010

    • Author(s)
      Natsugoe S.
    • Organizer
      The 2^<nd> National Yang-Ming University Hospital International Symposium
    • Place of Presentation
      Taiwan
    • Year and Date
      2010-06-27
  • [Presentation] Identification of micrometastasis in sentinel node usig immunohistochemical staining and RT-PCR for gastric cancer2009

    • Author(s)
      Natsugoe S.
    • Organizer
      The 8^<th> International Gastric Cancer Congress
    • Place of Presentation
      Krakow, Poland
    • Year and Date
      2009-06-11

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Published: 2013-07-31  

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