2011 Fiscal Year Final Research Report
Preclinical study for tolerance induction in lung transplantation
| Project/Area Number |
21390386
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | 公益財団法人田附興風会 (2011)
Kyoto University (2009-2010) |
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Principal Investigator |
SHOJI Tsuyoshi 公益財団法人田附興風会, 医学研究所第1研究部, 研究員 (80402840)
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| Co-Investigator(Kenkyū-buntansha) |
DATE Hiroshi 京都大学, 医学研究科, 教授 (60252962)
BANDO Toru 京都大学, 医学研究科, 准教授 (20293954)
SAKAI Hiroaki 京都大学, 医学研究科, 講師 (50362489)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 呼吸器外科学 |
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| Research Abstract |
In the study of lung allograft using miniature swine as preclinical model, an adoptive transfer of ex vivo donor alloantigen-stimulated CD4^+CD25^+FoxP3^+Tregs combined with low dose tacrolimus ameliorates rejection of immunogenic lung transplantation and prolonged lung allograft survival in clinically relevant miniature swine.
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