2011 Fiscal Year Final Research Report

Comprehensive analysis of novel genes regulating the malignant transformation in small-sized lung adenocarcinoma

Research Project

Project/Area Number	21390390
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	Thoracic surgery
Research Institution	Hiroshima University
Principal Investigator	OKADA Morihito 広島大学, 原爆放射線医科学研究所, 教授 (70446045)
Co-Investigator(Kenkyū-buntansha)	ITO Akihiko 近畿大学, 医学部, 教授 (80273647)
Project Period (FY)	2009 – 2011
Keywords	腫瘍学 / 小型肺がん / 肺胞上皮癌 / 肺腺癌
Research Abstract	The transcription factors Notch2 and Six1 were upregulated in invasive cancer cells in all minimally invasive adenocarcinomas. Exogenous Notch2 transactivated Six1 followed by Smad3, Smad4, and vimentin, and enlarged the nuclei of NCI-H441 lung epithelial cells. Immunochemical staining for the transcription factors was double positive in the invasive, but not in the lepidic growth component of a third of advanced Ads, and the disease-free survival rates were lower in such tumors. Paired upregulation of Notch2 and Six1 is a transcriptional aberration that contributes to preinvasive-to-invasive adenocarcinoma progression by inducing epithelial-mesenchymal transition and nuclear atypia. This aberration persisted in a considerable subset of advanced adenocarcinoma and conferred a more malignant phenotype on the subset

(2 results)