Development of the new approach for cardiac repair by enhancing endogenous regeneration

2011 Fiscal Year Final Research Report

• Project/Area Number: 21390391
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Yamaguchi University
• Principal Investigator: MIKAMO Akihito 山口大学, 医学部附属病院, 講師 (30372709)
• Co-Investigator(Kenkyū-buntansha): HAMANO Kimikazu 山口大学, 大学院・医学系研究科, 教授 (60263787) ; HAYASHI Masataro 山口大学, 医学部附属病院, 助教 (00554057)
• Project Period (FY): 2009 – 2011
• Keywords: 心筋再生 / メカニカルストレス / 再生医療 / 幹細胞

Research Abstract

Recent studies show that cardiac stem cells and mitotic cardiomyocytes have been identified in the failing and infracted hearts, suggesting that the heart may have regenerative potential. Substantial recovery of cardiac function by the implantation of a left ventricular assist device(LVAD) was found in some patients with heart failure. We speculate that reduction in mechanical stress achieved by LVAD support promotes cardiac regeneration by improving local environment. This study shows that reduction in mechanical stress assists the regeneration of the injured hearts. Furthermore, our findings suggest that mechanical stress suppresses the growth of cardiac stem cells, increases their release of the angiogenic factors, and enhances their myogenic differentiation.

Research Products

• [Journal Article] The effects of mechanical stress on the growth, differentiation, and paracrine factor production of cardiac stem cells (2011)
  • Author(s): Kurazumi H, Kubo M, Ohshima M, Yamamoto Y, Takemoto Y, Suzuki R, Ikenaga S, Mikamo A, Udo K, Hamano K, Li TS
  • Journal Title: PLoS One Volume: 6(12) Pages: e28890
  • Peer Reviewed
• [Journal Article] Identification of risk factors related to poor angiogenic potency of bone marrow cells from different patients (2009)
  • Author(s): Li TS, Kubo M, Ueda K, Murakami M, Ohshima M, Kobayashi T, Tanaka T, Shirasawa B, Mikamo A, Hamano K
  • Journal Title: Circulation Volume: 120(11) Pages: S255-S261
  • Peer Reviewed
• [Journal Article] Ischemic pre-conditioning enhances the mobilization and recruitment of bone marrow stem cells to protect against ischemia/ reperfusion injury in the late phase (2009)
  • Author(s): Kamota T, Li TS, Morikage N, Murakami M, Ohshima M, Kubo M, Kobayashi T, Mikamo A, Ikeda Y, Matsuzaki M, Hamano K
  • Journal Title: J Am Coll Cardiol Volume: 53(19) Pages: 1814-1822
  • Peer Reviewed
• [Presentation] Mechanical stress suppresses the proliferation and improves the differentiation of cardiac stem cells and increases the release of paracrine factors (2012)
  • Author(s): Kurazumi H, Li TS, Kubo M, Takemoto Y, Ohshima M, Mikamo A, Hamano K
  • Organizer: The Asian Society for Cardiovascular and Thoracic Surgery(2012 annual meeting)
  • Place of Presentation: Bali International Convention Center, Nusa Dua,(Bali, INDONESIA)
  • Year and Date: 2012-03-11
• [Presentation] メカニカルストレスが心筋幹細胞へ及ぼす影響 (2011)
  • Author(s): 藏澄宏之, 李桃生, 工藤智明, 鈴木亮, 久保正幸, 池永茂, 白澤文吾, 美甘章仁, 濱野公一
  • Organizer: 第99回日本循環器学会中国地方会
  • Place of Presentation: 下関海峡タワー(山口県)
  • Year and Date: 2011-11-26
• [Presentation] メカニカルストレスが心筋幹細胞へ及ぼす影響 (2011)
  • Author(s): 藏澄宏之, 李桃生, 池田聡, 大島真子, 工藤智明, 竹本圭宏, 鈴木亮, 久保正幸, 池永茂, 白澤文吾, 美甘章仁, 濱野公一
  • Organizer: 第64回日本胸部外科学会定期学術集会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-11