Convection-enhanced delivery of micellar retinoic acid as a new treatment strategy for malignant glioma

2011 Fiscal Year Final Research Report

• Project/Area Number: 21390401
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Tohoku University
• Principal Investigator: KUMABE Toshihiro 東北大学, 大学院・医学系研究科, 准教授 (10250747)
• Co-Investigator(Kenkyū-buntansha): SONODA Yukihiko 東北大学, 病院, 講師 (90302140) ; SAITO Ryuta 東北大学, 大学院・医学系研究科, 助教 (10400243)
• Project Period (FY): 2009 – 2011
• Keywords: 脳腫瘍 / 分化誘導療法 / ドラッグデリバリー / 薬剤担体

Research Abstract

We evaluated the efficacy of intracerebral administration of polymeric micellar synthetic retinoid(Am80)by convection-enhanced delivery(CED)combined with systemic admin istration of temozolomide in a U87MG intracranial xenograft model. As a result, CED of micellar Am80 provided significantly longer survival(P<0. 05). Combination of CED of micellar Am80 and systemic treatment of temozolomide provided significantly longer s urvival than the single treatment(P<0. 005, P<0. 005). Consequently, Temozolomide combined with CED administration of Am80 may be a promising strategy for the treatment of malignant gliomas.

Research Products

• [Journal Article] Clinicopathological analysis of nine consecutive central nervous system primitive neuroectodermal tumors in a single institute (2012)
  • Author(s): Aizawa-Kohama M, Kumabe T, Saito R, Kanamori M, Yamashita Y, Sonoda Y, Watanabe M, Tominaga T.
  • Journal Title: Brain Tumor Pathol Volume: 21
  • Peer Reviewed
• [Journal Article] IDH1/2 gene status defines the prognosis and molecular profiles in patients with grade III gliomas (2011)
  • Author(s): Shibahara I, Sonoda Y, Kanamori M, Saito R, Yamashita Y, Kumabe T, Watanabe M, Suzuki H, Kato S, Ishioka C, Tominaga T.
  • Journal Title: Int J Clin Oncol Volume: 6
  • Peer Reviewed
• [Journal Article] Preoperative evaluation of the deep cerebral veins using 3-tesla magnetic resonance imaging (2011)
  • Author(s): Saito R, Kumabe T, Kanamori M, Yamashita Y, Sonoda Y, Higano S, Takahashi S, Tominaga T.
  • Journal Title: Minim Invasive Neurosurg Volume: 54(3) Pages: 105-9
  • Peer Reviewed
• [Journal Article] Local convection-enhanced delivery of chemotherapeutic agent transiently opens blood-brain barrier and improves efficacy of systemic chemotherapy in intracranial xenograft tumor model (2011)
  • Author(s): Nakamura T, Saito R, Sugiyama S, Sonoda Y, Kumabe T, Tominaga T.
  • Journal Title: Cancer Lett Volume: 310(1) Pages: 77-83
  • Peer Reviewed
• [Journal Article] New insights into glioma classification based on isocitrate dehydrogenase 1 and 2 gene status (2011)
  • Author(s): Shibahara I, Sonoda Y, Kanamori M, Saito R, Kumabe T, Tominaga T.
  • Journal Title: Brain Tumor Pathol Volume: 28(3) Pages: 203-8
  • Peer Reviewed
• [Journal Article] Combination chemotherapy with ifosfamide, cisplatin, and etoposide for medulloblastoma : single-institute experience and differences in efficacy for subgroups of medulloblastoma (2011)
  • Author(s): Saito R, Kumabe T, Sonoda Y, Kanamori M, Yamashita Y, Watanabe M, Tominaga T.
  • Journal Title: Childs Nerv Syst Volume: 27(9) Pages: 1399-406
  • Peer Reviewed
• [Journal Article] Regression of recurrent glioblastoma infiltrating the brainstem after convection-enhanced delivery of nimustine hydrochloride (2011)
  • Author(s): Saito R, Sonoda Y, Kumabe T, Nagamatsu K, Watanabe M, Tominaga T.
  • Journal Title: J Neurosurg Pediatr Volume: 7(5) Pages: 522-6
  • Peer Reviewed
• [Journal Article] Logarithmic decrease of serum alpha-fetoprotein or human chorionic gonadotropin in response to chemotherapy can distinguish a subgroup with better prognosis among highly malignant intracranial non-germinomatous germ cell tumors (2011)
  • Author(s): Kawaguchi T, Kumabe T, Kanamori M, Saito R, Yamashita Y, Sonoda Y, Watanabe M, Tominaga T.
  • Journal Title: J Neurooncol Volume: 104(3) Pages: 779-87
  • Peer Reviewed
• [Journal Article] Infratentorial brain metastases of pediatric non-epithelial malignant tumors : three case reports (2011)
  • Author(s): Osawa S, Kumabe T, Saito R, Sonoda Y, Niizuma H, Watanabe M, Tominaga T.
  • Journal Title: Brain Tumor Pathol Volume: 28(2) Pages: 167-74
  • Peer Reviewed
• [Journal Article] Early detection of venous thromboembolism in patients with neuroepithelial tumor : efficacy of screening with serum D :-dimer measurements and Doppler ultrasonography (2011)
  • Author(s): Kawaguchi T, Kumabe T, Kanamori M, Nakamura T, Saito R, Yamashita Y, Sonoda Y, Watanabe M, Tominaga T.
  • Journal Title: J Neurooncol Volume: 101(3) Pages: 495-504
  • Peer Reviewed
• [Journal Article] he safety of combination chemotherapy with ifosfamide, cisplatin, and etoposide(ICE): single-institution retrospective review of 108 cases (2010)
  • Author(s): Kanamori M, Kumabe T, Saito R, Yamashita Y, Sonoda Y, Tominaga T.
  • Journal Title: Shinkei Geka Volume: 38(11) Pages: 997-1005
  • Peer Reviewed
• [Journal Article] Convection-enhanced delivery of a synthetic retinoid Am80, loaded into polymeric micelles, prolongs the survival of rats bearing intracranial glioblastoma xenografts (2010)
  • Author(s): Yokosawa M, Sonoda Y, Sugiyama S, Saito R, Yamashita Y, Nishihara M, Satoh T, Kumabe T, Yokoyama M, Tominaga T.
  • Journal Title: Tohoku J Exp Med Volume: 221(4) Pages: 257-64
  • Peer Reviewed
• [Journal Article] Insulo-opercular gliomas : four different natural progression patterns and implications for surgical indications (2010)
  • Author(s): Saito R, Kumabe T, Kanamori M, Sonoda Y, Tominaga T.
  • Journal Title: Neurol Med Chir(Tokyo) Volume: 50(4) Pages: 286-290
  • Peer Reviewed
• [Journal Article] Melanotic neuroectodermal tumor of the brain recurring 12 years after complete remission : case report (2010)
  • Author(s): Omodaka S, Saito R, Kumabe T, Kawagishi J, Jokura H, Sonoda Y, Watanabe M, Kayama T, Tominaga T.
  • Journal Title: Brain Tumor Pathol Volume: 50(4) Pages: 286-90
  • Peer Reviewed
• [Journal Article] Methylguanine DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression is correlated with progression-free survival in patients with glioblastoma (2010)
  • Author(s): Sonoda Y, Yokosawa M, Saito R, Kanamori M, Yamashita Y, Kumabe T, Watanabe M, Tominaga T.
  • Journal Title: Int J Clin Oncol Volume: 15(4) Pages: 352-8
  • Peer Reviewed
• [Journal Article] Dissemination limits the survival of patients with anaplastic ependymoma after extensive surgical resection, meticulous follow up, and intensive treatment for recurrence (2010)
  • Author(s): Saito R, Kumabe T, Kanamori M, Sonoda Y, Tominaga T.
  • Journal Title: Neurosurg Rev Volume: 33(2) Pages: 185-91
  • Peer Reviewed
• [Journal Article] Imaging of hypoxic lesions in patients with gliomas by using positron emission tomography with 1-(2-[18F] fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole, a new 18F-labeled 2-nitroimidazole analog (2010)
  • Author(s): Shibahara I, Kumabe T, Kanamori M, Saito R, Sonoda Y, Watanabe M, Iwata R, Higano S, Takanami K, Takai Y, Tominaga T.
  • Journal Title: J Neurosurg Volume: 113(2) Pages: 358-68
  • Peer Reviewed
• [Journal Article] Tohoku Brain Tumor Study Group : Association of stem cell marker CD133 expression with dissemination of glioblastomas (2010)
  • Author(s): Sato A, Sakurada K, Kumabe T, Sasajima T, Beppu T, Asano K, Ohkuma H, Ogawa A, Mizoi K, Tominaga T, Kitanaka C, Kayama T
  • Journal Title: Neurosurg Rev Volume: 33 Pages: 175-183
  • Peer Reviewed
• [Journal Article] Development of the Japanese version of the Pediatric Quality of Life Inventory Brain Tumor Module (2010)
  • Author(s): Sato I, Higuchi A, Yanagisawa T, Mukasa A, Ida K, Sawamura Y, Sugiyama K, Saito N, Kumabe T, Terasaki M, Nishikawa R, Ishida Y, Kamibeppu K
  • Journal Title: Health Qual Life Outcomes Volume: 8 Pages: 38-38
  • Peer Reviewed
• [Journal Article] Intraoperative neuronavigation system without rigid pin fixation (2009)
  • Author(s): Akamatsu Y, Kumabe T, Kanamori M, Nagamatsu K, Saito R, Sonoda Y, Sato K, Tominaga T.
  • Journal Title: No Shinkei Geka Volume: 37(12) Pages: 1193-9
  • Peer Reviewed
• [Journal Article] Optimal treatment strategy for intracranial germ cell tumors : a single institution analysis (2009)
  • Author(s): Kanamori M, Kumabe T, Saito R, Yamashita Y, Sonoda Y, Ariga H, Takai Y, Tominaga T.
  • Journal Title: J Neurosurg Pediatr Volume: 4(6) Pages: 506-14
  • Peer Reviewed
• [Journal Article] Predictive factors for overall and progression-free survival, and dissemination in oligodendroglial tumors (2009)
  • Author(s): Kanamori M, Kumabe T, Sonoda Y, Nishio Y, Watanabe M, Tominaga T
  • Journal Title: J Neurooncol Volume: 93 Pages: 219-228
  • Peer Reviewed
• [Journal Article] Collision tumor of anaplastic oligodendroglioma and gangliocytoma : a case report. (2009)
  • Author(s): Takeuchi Y, Kanamori M, Kumabe T, Saito R, Sonoda Y, Watanabe M, Tominaga T.
  • Journal Title: Brain Tumor Pathol Volume: 26(2) Pages: 89-93
  • Peer Reviewed
• [Journal Article] Differential diagnosis between radiation necrosis and glioma progression using sequential proton magnetic resonance spectroscopy and methionine positron emission tomography (2009)
  • Author(s): Nakajima T, Kumabe T, Kanamori M, Saito R, Tashiro M, Watanabe M, Tominaga T.
  • Journal Title: Neurol Med Chir(Tokyo) Volume: 49(9) Pages: 394-401
  • Peer Reviewed
• [Journal Article] Analysis of IDH1 and IDH2 mutations in Japanese glioma patients (2009)
  • Author(s): Sonoda Y, Kumabe T, Nakamura T, Saito R, Kanamori M, Yamashita Y, Suzuki H, Tominaga T.
  • Journal Title: Cancer Sci Volume: 100(10) Pages: 1996-8
  • Peer Reviewed
• [Journal Article] Magnetic resonance imaging for preoperative identification of the lenticulostriate arteries in insular glioma surgery. Technical note (2009)
  • Author(s): Saito R, Kumabe T, Inoue T, Takada S, Yamashita Y, Kanamori M, Sonoda Y, Tominaga T.
  • Journal Title: J Neurosurg Volume: 111(2) Pages: 278-81
  • Peer Reviewed
• [Presentation] Safety and Feasibility of MRI guided convection-enhanced delivery of nimustine hydrochloride against recurrent glioma affecting brainstem (2011)
  • Author(s): Saito R, Sonoda Y, Yamashita Y, Kanamori M, Kumabe T, Tominaga T.
  • Organizer: 2011Society for Neurooncology Annual Meeting
  • Place of Presentation: Orange County, USA
  • Year and Date: 2011-11-20
• [Presentation] 悪性神経膠腫に対するConvection-enhanced delivery :現状と展望 (2011)
  • Author(s): 齋藤竜太、園田順彦、山下洋二、金森政之、隈部俊宏、冨永悌二
  • Organizer: 第70回日本脳神経外科学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-10-12
• [Presentation] MRI Guided Convection-Enhanced Delivery of Nimustine Hydrochloride Against Recurrent Glioma Affecting Brain Stem (2011)
  • Author(s): Saito R, Sonoda Y, Yamashita Y, Kanamori M, Kumabe T, Tominaga T.
  • Organizer: 8th Annual World Congress of IBMISPS on Brain, Spinal Cord Mapping and Image Guided Therapy
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2011-06-09
• [Presentation] Local Application of Chemotherapeutics Transiently Opens Blood-Brain Barrier and Improves Efficacy of Systemic Chemotherapy against Intracranial Xenograft Tumor Model (2010)
  • Author(s): Saito R, Nakamura T, Sonoda Y, Kumabe T, Tominaga T.
  • Organizer: 2010Society for Neurooncology Annual Meeting
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2010-11-19
• [Presentation] 神経膠腫における基本手技(シンポジウム:こだわりの手術) (2010)
  • Author(s): 隈部俊宏、冨永悌二
  • Organizer: 第15回日本脳腫瘍の外科学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-10-01
• [Presentation] What does awake surgery bring into the glioma surgery (2010)
  • Author(s): Kumabe T
  • Organizer: 2010 Current Trends in the Management of Malignant Gliomas
  • Place of Presentation: Tokyo
  • Year and Date: 2010-07-31
• [Presentation] Logarithmic Decrease of Serum Alpha-Fetoprotein Level in Response to Chemotherapy can Distinguish the Subgroup with better Prognosis Among Highly Malignant Intracranial Non-Germinomatous Germ Cell Tumors (2010)
  • Author(s): Kumabe T, Kawaguchi T, Saito R, Kanamori M, Yamashita Y, Sonoda Y, Watanabe M, Tominaga T
  • Organizer: ASNO2010 The 7th Meeting of Asian Society for Neuro
  • Place of Presentation: Oncology, Seoul
  • Year and Date: 2010-06-11
• [Presentation] Imaging of hypoxic lesion in glioma patients by PET with [18F]FRP-170, a new 18F-labeled 2-nitroimidazole analog (2010)
  • Author(s): Kumabe T, Shibahara I, Kanamori M, Saito R, Sonoda Y, Watanabe M, Iwata R, Higano S, Takanami K, Takai Y, Tominaga T
  • Organizer: 18th International Conference on Brain Tumor Research and Therapy
  • Place of Presentation: Travemunde, Germany
  • Year and Date: 2010-05-19
• [Presentation] 覚醒下手術の準備と実際(ランチョンセミナー:覚醒下手術) (2009)
  • Author(s): 隈部俊宏、冨永悌二
  • Organizer: 社団法人日本脳神経外科学会第68回学術総会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-15
• [Presentation] モニタリングは神経膠腫の長期生存を向上させたか?(シンポジウム) (2009)
  • Author(s): 隈部俊宏、齋藤竜太、金森政之、山下洋二、園田順彦、冨永悌二
  • Organizer: 社団法人日本脳神経外科学会第68回学術総会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-15
• [Book] 脳腫瘍の外科-社会が望む脳腫瘍外科 (2011)
  • Author(s): 隈部俊宏、冨永悌二
  • Total Pages: 215-224
  • Publisher: メディカ出版
• [Book] 松果体部腫瘍-Occipital transtentorial approach. ビジュアル脳神経外科 Anatomy & Surgical Approach 4 (2011)
  • Author(s): 隈部俊宏、冨永悌二
  • Total Pages: 100-111
  • Publisher: 株式会社メジカルビュー社
• [Book] 1. 低悪性度グリオーマ. イラストレイテッド脳腫瘍外科学. C-TV各種脳腫瘍の手術 (2011)
  • Author(s): 隈部俊宏
  • Total Pages: 114-117
  • Publisher: 株式会社医学書院
• [Book] Visualization of lateral lenticulostriate arteries using 3-tesla magnetic resonance imaging (2010)
  • Author(s): Kumabe T, Saito R, Kanamori M, Sonoda Y, Higano S, Takahashi S, Tominaga T
  • Total Pages: 295-303
  • Publisher: Springer-Verlag
• [Book] Ischemic complication associated with resection of opercular gliomas (2010)
  • Author(s): Kumabe T, Kanamori M, Saito R, Nagamatsu K, Sonoda Y, Higano S, Takahashi S, Tominaga T
  • Total Pages: 305-318
  • Publisher: Springer-Verlag
• [Book] 神経膠腫治療成績の変化. 新時代の脳腫瘍学-診断・治療の最前線-V. 脳腫瘍の治療. 概論. 日本臨床68巻 (2010)
  • Author(s): 隈部俊宏、冨永悌二
  • Total Pages: 311-319
  • Publisher: 株式会社日本臨床社
• [Book] 脳腫瘍-手術療法-I. 臓器部位別の治療戦略. がん治療最前線-米国癌学会(ASCO)のトピックスを中心に- (2010)
  • Author(s): 隈部俊宏、冨永悌二
  • Total Pages: 1-5
  • Publisher: 総合医学社発行
• [Book] 2. 星細胞腫に放射線治療は必要か (2010)
  • Author(s): 隈部俊宏、冨永悌二
  • Total Pages: 114-120
  • Publisher: 中外医学社発行
• [Book] Ependymoblastoma上衣芽腫 (2009)
  • Author(s): 隈部俊宏、渡辺みか
  • Total Pages: 95