2011 Fiscal Year Final Research Report
Convection-enhanced delivery of micellar retinoic acid as a new treatment strategy for malignant glioma
| Project/Area Number |
21390401
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Tohoku University |
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Principal Investigator |
KUMABE Toshihiro 東北大学, 大学院・医学系研究科, 准教授 (10250747)
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| Co-Investigator(Kenkyū-buntansha) |
SONODA Yukihiko 東北大学, 病院, 講師 (90302140)
SAITO Ryuta 東北大学, 大学院・医学系研究科, 助教 (10400243)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 脳腫瘍 / 分化誘導療法 / ドラッグデリバリー / 薬剤担体 |
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| Research Abstract |
We evaluated the efficacy of intracerebral administration of polymeric micellar synthetic retinoid(Am80)by convection-enhanced delivery(CED)combined with systemic admin istration of temozolomide in a U87MG intracranial xenograft model. As a result, CED of micellar Am80 provided significantly longer survival(P<0. 05). Combination of CED of micellar Am80 and systemic treatment of temozolomide provided significantly longer s urvival than the single treatment(P<0. 005, P<0. 005). Consequently, Temozolomide combined with CED administration of Am80 may be a promising strategy for the treatment of malignant gliomas.
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Research Products
(45 results)
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[Journal Article] IDH1/2 gene status defines the prognosis and molecular profiles in patients with grade III gliomas2011
Author(s)
Shibahara I, Sonoda Y, Kanamori M, Saito R, Yamashita Y, Kumabe T, Watanabe M, Suzuki H, Kato S, Ishioka C, Tominaga T.
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Journal Title
Int J Clin Oncol
Volume: 6
Peer Reviewed
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[Journal Article] Convection-enhanced delivery of a synthetic retinoid Am80, loaded into polymeric micelles, prolongs the survival of rats bearing intracranial glioblastoma xenografts2010
Author(s)
Yokosawa M, Sonoda Y, Sugiyama S, Saito R, Yamashita Y, Nishihara M, Satoh T, Kumabe T, Yokoyama M, Tominaga T.
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Journal Title
Tohoku J Exp Med
Volume: 221(4)
Pages: 257-64
Peer Reviewed
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[Journal Article] Imaging of hypoxic lesions in patients with gliomas by using positron emission tomography with 1-(2-[18F] fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole, a new 18F-labeled 2-nitroimidazole analog2010
Author(s)
Shibahara I, Kumabe T, Kanamori M, Saito R, Sonoda Y, Watanabe M, Iwata R, Higano S, Takanami K, Takai Y, Tominaga T.
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Journal Title
J Neurosurg
Volume: 113(2)
Pages: 358-68
Peer Reviewed
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[Journal Article] Tohoku Brain Tumor Study Group : Association of stem cell marker CD133 expression with dissemination of glioblastomas2010
Author(s)
Sato A, Sakurada K, Kumabe T, Sasajima T, Beppu T, Asano K, Ohkuma H, Ogawa A, Mizoi K, Tominaga T, Kitanaka C, Kayama T
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Journal Title
Neurosurg Rev
Volume: 33
Pages: 175-183
Peer Reviewed
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[Journal Article] Development of the Japanese version of the Pediatric Quality of Life Inventory Brain Tumor Module2010
Author(s)
Sato I, Higuchi A, Yanagisawa T, Mukasa A, Ida K, Sawamura Y, Sugiyama K, Saito N, Kumabe T, Terasaki M, Nishikawa R, Ishida Y, Kamibeppu K
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Journal Title
Health Qual Life Outcomes
Volume: 8
Pages: 38-38
Peer Reviewed
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[Presentation] Imaging of hypoxic lesion in glioma patients by PET with [18F]FRP-170, a new 18F-labeled 2-nitroimidazole analog2010
Author(s)
Kumabe T, Shibahara I, Kanamori M, Saito R, Sonoda Y, Watanabe M, Iwata R, Higano S, Takanami K, Takai Y, Tominaga T
Organizer
18th International Conference on Brain Tumor Research and Therapy
Place of Presentation
Travemunde, Germany
Year and Date
2010-05-19
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