2011 Fiscal Year Final Research Report
Overcoming therapy resistance of glioma via elucidation of the mechanisms underlying glioma stem cell maintenance
| Project/Area Number |
21390402
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NEMOTO Kenji 山形大学, 医学部, 教授 (10208291)
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| Co-Investigator(Renkei-kenkyūsha) |
SUNAYAMA Jun 山形大学, 医学部, 助教 (80466606)
TOMIYAMA Arata 山形大学, 医学部, 助教 (40385810)
TACHIBANA Ken 山形大学, 医学部, 助教 (10400540)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 脳腫瘍学 |
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| Research Abstract |
In this study, we searched for intracellular signals as well as signaling molecules involvedin the maintenance of glioblastoma stem cells and demonstrated critical roles for PI3K/mTOR and MAPK in glioblastoma stem cell maintenance. Significantly, PI3K/mTORand MAPK acted on a common molecule, i.e., the FOXO3 transcription factor, whoseactivity was restrained through phosphorylation by these kinases in glioblastoma stemcells. Our results suggest that FOXO3 as well as these kinases could be rational moleculartargets for stem cell-targeted glioblastoma therapies.
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Research Products
(27 results)
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[Journal Article] Targeting JNK for therapeutic depletion of stem-like glioblastomacells2012
Author(s)
Matsuda K, Sato A, Okada M, Shibuya K, Seino S, Suzuki K, Watanabe E, Narita Y, Shibui S, Kayama T, Kitanaka C
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Journal Title
Sci Rep
Volume: 2
Pages: 516
Peer Reviewed
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[Journal Article] Glioma-initiating cell elimination by metformin activation of FOXO3 via AMPK2012
Author(s)
Sato A, Sunayama J, Okada M, Watanabe E, Seino S, Shibuya K, Suzuki K, Narita Y, Shibui S, Kayama T, Kitanaka C
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Journal Title
Stem Cells Transl Med
Volume: 1
Pages: 811-824
Peer Reviewed
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[Journal Article] FoxO3a functions as a key integrator of cellular signals that control glioblastoma stem-like cell differentiation and tumorigenicity2011
Author(s)
Sunayama J, Sato A, Matsuda KI, Tachibana K, Watanabe E, Seino S, Suzuki K, Narita Y, Shibui S, Sakurada K, Kayama T, Tomiyama A, Kitanaka C
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Journal Title
Stem Cells
Volume: 29
Pages: 1327-1337
Peer Reviewed
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[Journal Article] Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells2010
Author(s)
Sunayama J, Matsuda KI, Sato A, Tachibana K, Suzuki K, Narita Y, Shibui S, Sakurada K, Kayama T, Tomiyama A, Kitanaka C
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Journal Title
StemCells
Volume: 28
Pages: 1930-1939
Peer Reviewed
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[Journal Article] Dual blocking of mTor and PI3K elicits a pro-differentiation effect on glioblastoma stem like-cells2010
Author(s)
Sunayama J, Sato A, Matsuda KI, Tachibana K, Suzuki K, Narita Y, Shibui S, Sakurada K, Kayama T, Tomiyama A, Kitanaka C
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Journal Title
Neuro-Oncol
Volume: 12
Pages: 1205-1219
Peer Reviewed
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[Journal Article] MEK-ERK-dependent multiple caspase activation via mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation-induced glioma celldeath2010
Author(s)
Tomiyama A, Tachibana K, Suzuki K, Seino S, Sunayama J, Matsuda KI, Sato A, Matsumoto Y, Nomiya T, Nemoto K, Yamashita H, Kayama T, Ando K, Kitanaka C
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Journal Title
Cell Death Dis
Volume: 1
Pages: e60
Peer Reviewed
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[Journal Article] Association of stem cell marker CD133 expression with dissemination of glioblastomas2010
Author(s)
Sato A, Sakurada K, Kumabe T, Sasajima T, Beppu T, Asano K, Ohkuma H, Ogawa A, Mizoi K, Tominaga T, Kitanaka C, Kayama T
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Journal Title
Neurosurg Rev
Volume: 33
Pages: 175-184
Peer Reviewed
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[Presentation] グリオーマ幹細胞における FoxO3aを介した分化と造腫瘍能の制御2011
Author(s)
佐藤篤,砂山潤,松田憲一朗,立花研,渡部江梨子,清野静香,鈴木香,成田善孝,渋井壮一郎,富山新太,北中千史,嘉山孝正
Organizer
第29回日本脳腫瘍学会学術総会
Place of Presentation
下呂(水明館)
Year and Date
2011-11-27
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