2011 Fiscal Year Final Research Report
Progress of anti-angiogenic therapy for brain tumors : new modality and resolution of the resistance
| Project/Area Number |
21390403
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
TAKANO Shingo 筑波大学, 医学医療系, 准教授 (50292553)
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| Co-Investigator(Kenkyū-buntansha) |
OHNEDA Osamu 筑波大学, 医学医療系, 教授 (30311872)
EMA Masatsugu 筑波大学, 医学医療系, 講師 (60359578)
ISHIKAWA Eiichi 筑波大学, 医学医療系, 講師 (30510169)
KUBOTA Yoshiaki 慶應義塾大学, 総合医科学研究センター, 特任講師 (50348687)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 膠芽腫 / 血管新生 / 腫瘍内皮細胞 / ケモカイン / 抵抗性 / 腫瘍微小環境 |
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| Research Abstract |
This study was designed to resolve the resistance and find a new generation anti-angiogenic therapy targeting glioblastoma endothelial cells.
1. Solution of anti-angiogenic treatment for glioblastoma : Metronomic treatment using CPT-11 was effective to glioma growth without systemic side effect (J Neuro-oncology, 2010).
2. Glioblastoma recurrence mouse model with continuous VEGF antibody treatment was established (Brain Tumor Pathol 2010, J Oncology 2010). With this model, Specific CXCR7 inhibitor, CCX771 and LMWH, antagnosit of SDF-1, inhibited recurrence after VEGF antibody treatment.
3.Vaccination with tumor endothelial cells and tumor cells inhibited glioma growth strongly compared to vaccination with tumor cell alone.
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[Journal Article] Immunohistochemical detection of IDH1 mutation, p53 and internexin as a prognostic marker of glial tumors2012
Author(s)
Takano S, Kato Y, Yamamoto T, Kaneko MK, Ishikawa E, Tsujimoto Y, Matsuda M, Nakai K, Yanagiya R, Morita S, Tsuboi K, Matsumura A
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Journal Title
DOI
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[Journal Article] Pathological changes after autologous formalin-fixed tumor vaccine therapy combined with temozolo mide for glioblastoma. three case reports-2011
Author(s)
Sakamoto N, Ishikawa E, Yamamoto T, Satomi K, Nakai K, Sato M, Enomoto T, Morishita Y, Takano S, Ohno T, Tsuboi K, Matsumura A
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Journal Title
Neurol Med Chir (Tokyo)
Volume: 51
Pages: 319-325
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