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2011 Fiscal Year Final Research Report

Developmental research on novel brain tumor therapy using recombinant oncolytic herpes viruses

Research Project

  • PDF
Project/Area Number 21390404
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionThe University of Tokyo

Principal Investigator

TODO Tomoki  東京大学, 医学部附属病院, 教授 (80272566)

Co-Investigator(Renkei-kenkyūsha) INO Yasushi  東京大学, 医科学研究所, 准教授 (50372371)
FUKUHARA Hiroshi  東京大学, 医学部附属病院, 講師 (20292948)
TANAKA Minoru  東京大学, 医科学研究所, 特任講師 (50332581)
Project Period (FY) 2009 – 2011
Keywords脳腫瘍 / ウイルス療法 / 単純ヘルペスウイルスI型 / ウイルスベクター / 腫瘍免疫
Research Abstract

We performed a developmental research on recombinant oncolytic viruses that possess certain antitumor functions and are useful for brain tumor therapy. A third-generation oncolytic herpes simplex virus type 1(G47.) was used as the backbone to insert foreign sequences. Oncolytic viruses that express immune-stimulatory factors or luciferase, or that use tumor-specific promoters, were constructed and evaluated, and proved to be highly useful. G47. is expected as a new drug for brain tumors in the near future, and a progress has been made in the basic development of next generation onoclytic virus therapy.

  • Research Products

    (33 results)

All 2012 2011 2010 2009

All Journal Article (19 results) (of which Peer Reviewed: 11 results) Presentation (14 results)

  • [Journal Article] Active immunotherapy : Oncolytic virus therapy using HSV-12012

    • Author(s)
      Todo T
    • Journal Title

      Adv Exp Med Biol

      Volume: 746巻 Pages: 178-186

  • [Journal Article] Extended field stereotactic radiosurgery for recurrent glioblastoma2011

    • Author(s)
      Koga T, Maruyama K, Tanaka M, Ino Y, Saito N, Nakagawa K, Shibahara J, Todo T
    • Journal Title

      Cancer

    • DOI

      DOI:10.1002/cncr.27372

    • Peer Reviewed
  • [Journal Article] Gioma-initiating cells retain their tumorigenicity through integration of the Sox axis and Oct4 protein2011

    • Author(s)
      Saito N, Miyazawa K, Miyazono K
    • Journal Title

      J Biol Chem

      Volume: Vol.286、No.48 Pages: 41434-41441

    • DOI

      DOI:10.1074/jbc.M111.300863

    • Peer Reviewed
  • [Journal Article] 悪性脳腫瘍の遺伝子治療2011

    • Author(s)
      藤堂具紀、稲生靖
    • Journal Title

      BIO Clinica

      Volume: 26巻、4号 Pages: 33-37

  • [Journal Article] Temozolomide may induce therapy-related acute lymphoblastic leukemia2011

    • Author(s)
      Ogura M, Todo T, Tanaka M, Nannya Y, Ichikawa M, Nakamura F, Kurokawa M
    • Journal Title

      Br J Haematol

      Volume: Vol.154、No.4 Pages: 663-665

    • Peer Reviewed
  • [Journal Article] NKX2. 2 suppresses self-renewal of glioma-initiating cells by induction of oligodendroglial differentiation2011

    • Author(s)
      Muraguchi T, Tanaka S, Tamase A, Nakada M, Nakamura H, Hoshii T, Ooshio T, Tadokoro Y, Naka K, Ino Y, Todo T, Kuratsu J, Saya H, Hamada J, Hirao A
    • Journal Title

      Cancer Res

      Volume: Vol.71、No.3 Pages: 1135-1145

    • DOI

      DOI:10.1158/0008-5472.CAN-10-2304

    • Peer Reviewed
  • [Journal Article] Homozygously deleted gene DACH1 regulates tumor-initiating activity of glioma cells2011

    • Author(s)
      Watanabe A, Ogiwara H, Ehata S, Mukasa A, Ishikawa S, Maeda D, Ueki K, Ino Y, Todo T, Yamada Y, Fukayama M, Saito N, Miyazono K, Aburatani H
    • Journal Title

      Proc Natl Aced Sci USA

      Volume: Vol.108、No.30 Pages: 12384-12389

    • DOI

      DOI:10.1073/pnas.0906930108

    • Peer Reviewed
  • [Journal Article] 悪性神経膠腫に対するヘルペスウイルス療法2011

    • Author(s)
      稲生靖、藤堂具紀
    • Journal Title

      Clinical Neuroscience

      Volume: 29巻、2号 Pages: 229-231

  • [Journal Article] 悪性脳腫瘍のウイルス療法2010

    • Author(s)
      稲生靖、藤堂具紀
    • Journal Title

      Biotherapy

      Volume: 24巻、6号 Pages: 443-447

  • [Journal Article] Clinical development of a third-generation oncolytic HSV-1(G47△) for malignant glioma2010

    • Author(s)
      Ino Y, Todo T
    • Journal Title

      Gene Therapy and Regulation

      Volume: Vol.5、No.1 Pages: 101-111

    • Peer Reviewed
  • [Journal Article] 悪性脳腫瘍に対するウイルス療法2010

    • Author(s)
      稲生靖、藤堂具紀
    • Journal Title

      日本臨床(増刊号新時代の脳腫瘍学.診断・治療の最前線)

      Volume: 68巻 Pages: 473-477

  • [Journal Article] 神経膠腫の遺伝子治療2010

    • Author(s)
      高橋雅道、藤堂具紀
    • Journal Title

      脳神経外科速報

      Volume: 20巻、7号 Pages: 798-806

  • [Journal Article] 悪性脳腫瘍に対するウイルス療法2010

    • Author(s)
      稲生靖、藤堂具紀
    • Journal Title

      感染・炎症・免疫

      Volume: 40巻 Pages: 81-83

  • [Journal Article] Oncolytic virus therapy for prostate cancer2010

    • Author(s)
      Fukuhara H, Homma Y, Todo T
    • Journal Title

      Int. J. Urol

      Volume: Vol.17、No.1 Pages: 20-30

    • DOI

      DOI:10.1111/j.1442-2042.2009.02383.x.

    • Peer Reviewed
  • [Journal Article] Autocrine TGF-βsignaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors2009

    • Author(s)
      Ikushima H, Todo T, Ino Y, Takahashi M, Miyazawa K, Miyazono K
    • Journal Title

      Cell Stem Cell

      Volume: Vol.5、No.5 Pages: 504-514

    • Peer Reviewed
  • [Journal Article] 悪性脳腫瘍に対するウイルス療法2009

    • Author(s)
      稲生靖、藤堂具紀
    • Journal Title

      BRAIN and NERVE

      Volume: 61巻、7号 Pages: 442-446

    • Peer Reviewed
  • [Journal Article] Low-grade gliomaの治療オプションと放射線治療のタイミング2009

    • Author(s)
      田中実、藤堂具紀
    • Journal Title

      脳神経外科ジャーナル

      Volume: 8巻、6号 Pages: 442-446

  • [Journal Article] The motor-evoked potential threshold evaluated by tractography and electrical stimulation2009

    • Author(s)
      Kamada K, Todo T, Ota T, Ino K, Masutani Y, Aoki S, Takeuchi F, Kawai K, Saito N
    • Journal Title

      J Neurosurg

      Volume: Vol.111、No.4 Pages: 785-795

    • DOI

      DOI:10.3171/2008.9.JNS08414

    • Peer Reviewed
  • [Journal Article] Long-term control of disseminated pleomorphic xanthoastrocytoma with anaplastic features by means of stereotactic irradiation2009

    • Author(s)
      Koga T, Morita A, Maruyama K, Tanaka M, Ino Y, Shibahara J, Louis DN, Reifenberger G, Itami J, Hara R, Saito N, Todo T
    • Journal Title

      Neuro-Oncolog

      Volume: Vol.11、No.2 Pages: 446-451

    • DOI

      DOI:10.1215/15228517-2008-112

    • Peer Reviewed
  • [Presentation] Novel treatment-Oncolytic virus therapy2011

    • Author(s)
      藤堂具紀
    • Organizer
      The 24^<th> International Symposium in Tokyo Malignant Brain Tumors : The present status and future prospects
    • Place of Presentation
      東京
    • Year and Date
      20111123-25
  • [Presentation] A clinical study of a third-generation oncolytic HSV-1(G47Δ) in patients with recurrent glioblastoma2011

    • Author(s)
      藤堂具紀、稲生靖
    • Organizer
      第17回日本遺伝子治療学会
    • Place of Presentation
      福岡
    • Year and Date
      20110715-17
  • [Presentation] 悪性グリオーマのウイルス療法2011

    • Author(s)
      藤堂具紀、稲生靖
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
  • [Presentation] Clinical development of a third-generation oncolytic HSV-1(G47Δ) for recurrent glioblastoma2011

    • Author(s)
      Todo T, Ino Y.
    • Organizer
      US-Japan Joint Seminars "Trends of gene & cell therapy as translational research in USA and Japan"
    • Place of Presentation
      福岡
    • Year and Date
      2011-07-14
  • [Presentation] 遺伝子組換えヘルペスウイルスG47Δを用いたウイルス療法の開発2011

    • Author(s)
      藤堂具紀
    • Organizer
      第9回遺伝子治療シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2011-02-01
  • [Presentation] 第三世代HSV-1(G47△)を用いた再発膠芽腫に対するウイルス療法の臨床研究2010

    • Author(s)
      藤堂具紀、稲生靖
    • Organizer
      第48回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      20101028-30
  • [Presentation] 再発膠芽腫に対するウイルス療法: First-in-Man臨床研究の進捗状況2010

    • Author(s)
      藤堂具紀、田中実、高橋雅道、斎藤邦昭、辛正廣、甲賀智之、武笠晃丈、斉藤延人、稲生靖
    • Organizer
      日本脳神経外科学会第69回学術総会
    • Place of Presentation
      福岡
    • Year and Date
      20101027-29
  • [Presentation] Clinical development of a third-generation recombinant oncolytic HSV-1, G47Δ, for recurrent glioblastoma in Japan2010

    • Author(s)
      Todo T, Ino Y.
    • Organizer
      The 18^<th> International Conference on Brain Tumor Research and Therapy
    • Place of Presentation
      Travemuende, Germany
    • Year and Date
      20100517-20
  • [Presentation] 新たな治療の可能性(ウイルス療法)2010

    • Author(s)
      藤堂具紀
    • Organizer
      第30回日本脳神経外科コングレス総会
    • Place of Presentation
      横浜
    • Year and Date
      20100507-09
  • [Presentation] 悪性脳腫瘍のウイルス療法2010

    • Author(s)
      藤堂具紀
    • Organizer
      第28回日本脳腫瘍学会学術集会
    • Place of Presentation
      軽井沢
    • Year and Date
      2010-11-29
  • [Presentation] 脳腫瘍のウイルス療法2010

    • Author(s)
      藤堂具紀
    • Organizer
      第14回北海道脳腫瘍懇話会
    • Place of Presentation
      札幌
    • Year and Date
      2010-03-12
  • [Presentation] 我が国におけるウイルス療法の臨床開発2010

    • Author(s)
      藤堂具紀
    • Organizer
      第8回遺伝子治療シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2010-02-05
  • [Presentation] 遺伝子組換えヘルペスウイルスを用いたがんのウイルス療法の開発2009

    • Author(s)
      藤堂具紀
    • Organizer
      第5回遺伝子治療推進産学懇話会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-24
  • [Presentation] 脳腫瘍に対するウイルス療法開発に見る我が国のトランレーショナルリサーチ2009

    • Author(s)
      藤堂具紀、稲生靖
    • Organizer
      第10回日本分子脳神経外科学会
    • Place of Presentation
      岡山
    • Year and Date
      2009-09-19

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Published: 2013-07-31   Modified: 2015-12-09  

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