Mechanisms of cerebral aneurysmal occurrence, growth and rupture and development of new treatments

2011 Fiscal Year Final Research Report

• Project/Area Number: 21390411
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Shiga University of Medical Science
• Principal Investigator: NOZAKI Kazuhiko 滋賀医科大学, 医学部, 教授 (90252452)
• Co-Investigator(Kenkyū-buntansha): JITO Junya 滋賀医科大学, 医学部, 助教 (50534161) ; NISHIMURA Masaki 京都大学, 医学研究科, 助教 (60452348) ; YOKOI Toshihiro 滋賀医科大学, 医学部, 助教 (20573182) ; INUBUSHI Toshiro 滋賀医科大学, MR医学総合研究センター, 教授 (20213142) ; MORIKAWA Shigehiro 滋賀医科大学, 医学部, 教授 (60220042)
• Project Period (FY): 2009 – 2011
• Keywords: 脳動脈瘤 / 動物モデル / 薬物治療 / MR画像 / 分子イメージング

Research Abstract

In order to elucidate the mechanisms of cerebral aneurysmal development, growth, rupture, we conducted molecular an histological analyses in induced aneurismal models of rats and monkeys. Induced aneurysms were successfully checked using 7T-MRA and the administration of statins, TNF-αinhibitors suppressed the development of cerebral aneurysms by inhibiting inflammatory processes.

Research Products

• [Journal Article] A simple way to acquire T(1)-weighted MR images of rat liver with respiratory triggering (2012)
  • Author(s): Morikawa S, Murayama H, Fujimoto S, Shiino A, Inubushi T.
  • Journal Title: Magn Reson Imaging Volume: 30(3) Pages: 153-8
  • Peer Reviewed
• [Journal Article] The profile of hippocampal metabolites differs between Alzheimer's disease and subcortical ischemic vascular dementia, as measured by proton magnetic resonance spectroscopy (2012)
  • Author(s): Shiino A, Watanabe T, Shirakashi Y, Kotani E, Yoshimura M, Morikawa S, Inubushi T, Akiguchi I.
  • Journal Title: J Cereb Blood Flow Metab Volume: 32(5) Pages: 805-15
  • Peer Reviewed
• [Journal Article] 動脈硬化に関する研究と今後の展開脳動脈瘤研究と薬物治療 (2012)
  • Author(s): 横井俊浩, 齊藤実, 吉村弥生, 野崎和彦
  • Journal Title: 滋賀医科大学雑誌(電子ジャーナル版)
• [Journal Article] 脳動脈瘤予防とスタチン (2011)
  • Author(s): 青木友浩、野崎和彦
  • Journal Title: 脳神経外科速報 Volume: 21 Pages: 64-71
• [Journal Article] In vivo detection of amyloidβdeposition using^<19> F magnetic resonance imaging with a 1. F-containing curcumin derivative in a mouse model of Alzheimer's disease (2011)
  • Author(s): Yanagisawa D, Amatsubo T, Morikawa S, Taguchi H, Urushitani M, Shirai N, Hirao K, Shiino A, Inubushi T, Tooyama I.
  • Journal Title: Neuroscience 16 Volume: 184 Pages: 120-7
  • Peer Reviewed
• [Journal Article] Morphometric characterization of Binswanger's disease : Comparison with Alzheimer's disease (2011)
  • Author(s): Shiino A, Akiguchi I, Watanabe T, Shirakashi Y, Nozaki K, Tooyama I, Inubushi T.
  • Journal Title: Eur J Radiol
  • Peer Reviewed
• [Journal Article] 細胞外基質の産生分解から見た脳動脈瘤増大機構の解析と治療への展望 (2010)
  • Author(s): 青木友浩、西村真樹、片岡大治、石橋良太、森下竜一、野崎和彦、橋本信夫、宮本享
  • Journal Title: 脳卒中 Volume: 32 Pages: 538-543
  • Peer Reviewed
• [Journal Article] 脳動脈瘤発生・増大のメカニズム (2010)
  • Author(s): 横井俊浩、野崎和彦
  • Journal Title: 脳神経外科 Volume: 38 Pages: 787-793
• [Journal Article] 脳卒中の先端治療研究臨床への道NF-kappaB活性化を中心とした脳動脈瘤形成の分子機序の解明と臨床応用への展望 (2009)
  • Author(s): 青木友浩、西村真樹、高木康志、片岡大治、石橋良太、森下竜一、橋本信夫、野崎和彦
  • Journal Title: 脳卒中 Volume: 31 Pages: 425-432
  • Peer Reviewed
• [Presentation] 脳動脈瘤の発生と病理 (2011)
  • Author(s): 野崎和彦
  • Organizer: 第4回脳血管手術研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-07-24
• [Presentation] 脳動脈瘤の成因予防 (2011)
  • Author(s): 野崎和彦
  • Organizer: 第14回日本病院脳神経外科学会
  • Place of Presentation: 愛媛
  • Year and Date: 2011-07-17
• [Presentation] 脳動脈瘤の成因から見た薬物療法の可能性 (2011)
  • Author(s): 野崎和彦
  • Organizer: 第20回日本脳ドック学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-07-08
• [Presentation] 脳動脈瘤基礎と臨床 (2011)
  • Author(s): 野崎和彦
  • Organizer: 第34回香川脳血管障害研究会
  • Place of Presentation: 香川
  • Year and Date: 2011-03-04
• [Presentation] Molecular and genetic analysis for cerebral aneurysms (2010)
  • Author(s): Nozaki K.
  • Organizer: 2010 Congress of Neurological Surgeons Annual Meeting
  • Place of Presentation: San Francisco
  • Year and Date: 20101016-21
• [Presentation] 脳動脈瘤の予防・治療 (2010)
  • Author(s): 野崎和彦
  • Organizer: 第14回北海道脳卒中勉強会
  • Place of Presentation: 札幌
  • Year and Date: 2010-07-10
• [Presentation] 脳動脈瘤の成因と予防 (2010)
  • Author(s): 野崎和彦
  • Organizer: 第5回上総脳卒中予防研究会
  • Place of Presentation: 千葉
  • Year and Date: 2010-03-11
• [Presentation] Molecular and genetic analysis for cerebral aneurysms(Key Note Lecture) (2010)
  • Author(s): Nozaki K.
  • Organizer: 5^<th> International Mt. BANDAI Symposium for Neuroscience
  • Place of Presentation: Hawaii
  • Year and Date: 2010-01-25
• [Presentation] 脳動脈瘤の発症機序および新しい治療法の可能性 (2009)
  • Author(s): 野崎和彦
  • Organizer: 第19回脳血管シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2009-09-12
• [Presentation] 脳動脈瘤成因と予防 (2009)
  • Author(s): 野崎和彦
  • Organizer: 第13回宮城県脳ドック研究会
  • Place of Presentation: 仙台
  • Year and Date: 2009-07-21
• [Presentation] 脳動脈瘤成因と予防 (2009)
  • Author(s): 野崎和彦
  • Organizer: 第18回日本脳ドック学会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-03
• [Book] 未破裂脳動脈瘤に対する薬物療法神経疾患最新の治療 (2012)
  • Author(s): 青木友浩、野崎和彦
  • Total Pages: 6-9
  • Publisher: 南江堂
• [Book] 脳動脈瘤の発生増大のメカニズム (2011)
  • Author(s): 横井俊浩、青木友浩、齋藤実、野崎和彦
  • Total Pages: 107-115
  • Publisher: 医学のあゆみ
• [Book] 脳動脈瘤治療薬としてのスタチン製剤の可能性脳と循環 (2010)
  • Author(s): 青木友浩、西村真樹、野崎和彦、宮本享
  • Total Pages: 207-211
• [Book] 脳動脈瘤と炎症 (2010)
  • Author(s): 横井俊浩、青木友浩、野崎和彦
  • Total Pages: 938-940
  • Publisher: Clinical Neuroscience
• [Book] 第5節脳血管疾患、第6項脳動脈瘤「モデル動物利用マニュアル」シリーズ「疾患モデルの作製と利用-循環器疾患」エルアイシー (2010)
  • Author(s): 横井俊浩、野崎和彦
• [Book] 未破裂脳動脈瘤の最新エビデンスと治療 (2009)
  • Author(s): 横井俊浩、森田明夫、野崎和彦
  • Total Pages: 535-540
  • Publisher: 医学のあゆみ