2011 Fiscal Year Final Research Report
Mechanisms of cerebral aneurysmal occurrence, growth and rupture and development of new treatments
| Project/Area Number |
21390411
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
JITO Junya 滋賀医科大学, 医学部, 助教 (50534161)
NISHIMURA Masaki 京都大学, 医学研究科, 助教 (60452348)
YOKOI Toshihiro 滋賀医科大学, 医学部, 助教 (20573182)
INUBUSHI Toshiro 滋賀医科大学, MR医学総合研究センター, 教授 (20213142)
MORIKAWA Shigehiro 滋賀医科大学, 医学部, 教授 (60220042)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 脳動脈瘤 / 動物モデル / 薬物治療 / MR画像 / 分子イメージング |
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| Research Abstract |
In order to elucidate the mechanisms of cerebral aneurysmal development, growth, rupture, we conducted molecular an histological analyses in induced aneurismal models of rats and monkeys. Induced aneurysms were successfully checked using 7T-MRA and the administration of statins, TNF-αinhibitors suppressed the development of cerebral aneurysms by inhibiting inflammatory processes.
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Research Products
(26 results)
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[Book] 脳動脈瘤と炎症2010
Author(s)
横井俊浩、青木友浩、野崎和彦
Total Pages
938-940
Publisher
Clinical Neuroscience
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