2011 Fiscal Year Final Research Report
The Research of the bioreactor that can promote the cell differentiation from bone marrow stem cells to osteogenic cells
| Project/Area Number |
21390419
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
ISHIGURO Naoki 名古屋大学, 大学院・医学系研究科, 教授 (20212871)
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| Co-Investigator(Kenkyū-buntansha) |
KITOH Hiroshi 名古屋大学, 医学部附属病院, 講師 (40291174)
SAKAI Tadahiro 名古屋大学, 医学部附属病院, 病院講師 (60378198)
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| Project Period (FY) |
2009 – 2011
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| Keywords | SOX9 / VEGF / ATDC5 / バイオリアクター |
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| Research Abstract |
We used ATDC5 cell and bone marrow stem cells(BMC) in the experiments. The expression of SOX9mRNA(chondorogenic marker) and RUNX2mRNA(osteogenic marker) was respectively demonstrated in the process of cell differentiation with suitable condition. The both mRNA expression were increased with the mechanical stimuli applied in this process of cell differentiation. The strength and cyclic rate were important for this process. The cell differentiation and matrix synthesis was exaggerated when the strong stimuli were applied. We could not obtained the VEGF producing cells from BMC with the hypoxia condition and mechanical stimuli.
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Research Products
(31 results)
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[Journal Article] Study protocol of a multicenter registry of patients with rheumatoid arthritis starting biologic therapy in Japan : TsurumaiBiologicsCommunication Registry(TBCR) Study2011
Author(s)
Kojima T, Kaneko A, Hirano Y, Ishikawa H, Miyake H, Oguchi T, Takagi H, YabeY, Kato T, Ito T, Terabe K, FukayaN, Kanayama Y, Shioura T, FunahashiK, Hayashi M, Kato D, MatsubaraH, Fujibayashi T, Kojima M, Ishiguro N
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Journal Title
Mod Rheumatol
Volume: (in press)
Peer Reviewed
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[Journal Article] Early aggressive intervention with tocilizumab for rheumatoid arthritis increases remission rate defined using a Boolean approach in clinical practice2011
Author(s)
Kojima T, Kaneko A, Hirano Y, IshikawaH, Miyake H, Takagi H, Yabe Y, Kato T, Terabe K, Fukaya N, Tsuchiya H, Shioura T, Funahashi K, Hayashi M, Kato D, Matsubara H, Ishiguro N
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Journal Title
Mod Rheumatol
Volume: (in press)
Peer Reviewed
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[Journal Article] Novel and recurrent TRPV4 mutations and their association with distinct phenotypes with in theTRPV4 dysplasia family2010
Author(s)
Dai J, Kim OH, Cho TJ, Schmidt-RimplerM, Tonoki H, Takikawa K, Haga N, Miyoshi K, Kitoh H, Yoo WJ, Choi IH, Song HR, Jin DK, Kim HT, Kamasaki H, Bianchi P, Grigelioniene G, NampoothiriS, Minagawa M, Miyagawa S, Fukao T, Marcelis C, Jansweijer MCE, HennekamRCM, Bedeschi F, Mustonen A, Jiang Q, Ohashi H, Furuichi T, Unger S, Zabel B, Lausch E, Superti-Furga A, NishimuraN, Ikegawa S
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Journal Title
J Med Genet
Volume: 47(10)
Pages: 704-709
Peer Reviewed
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[Journal Article] Spondylo-epiphyseal dysplasia, Maroteaux type(pseudo-Morquio syndrome type 2) and parastremmatic dy splasia are caused by TRPV4 mutations2010
Author(s)
Nishimura G, Dai J, Lausch E, Unger S, Megarbane A, Kitoh H, OH Kim, ChoTJ, Bedeschi F, Benedicenti F, Mendoza-Londono R, Silengo M, Schmidt-Rimpler M, Spranger J, Zabel B, Ikegawa S
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Journal Title
J Med Genet
Volume: 152A(6)
Pages: 1443-1449
Peer Reviewed
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[Journal Article] Psychosocial factors, disease status, and quality of life in patients with rheumatoid arthritis2009
Author(s)
Kojima M, Kojima T, Ishiguro N, OguchiT, Oba M, Tsuchiya H, Sugiura F, Furukawa TA, Suzuki S, Tokudome S
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Journal Title
J Psychosom Res
Volume: 67(5)
Pages: 425-31
Peer Reviewed
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