2011 Fiscal Year Final Research Report
Effective internalization of quantum-dots to mesenchymal stem cells and study of differentiation process of mesenchymal cells and tissues
| Project/Area Number |
21390429
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
UEMURA Toshimasa 独立行政法人産業技術総合研究所, ナノシステム研究部門, 主任研究員 (60176641)
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| Co-Investigator(Kenkyū-buntansha) |
RENU Wadhwa 独立行政法人産業技術総合研究所, バイオメディカル研究部門, 研究グープ長 (30371090)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 骨・軟代謝学 / 量子ドット / 間葉系幹細胞 |
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| Research Abstract |
We succeeded in developing techniques for effective internalization of quantum-dots(Q-dots) to mesenchymal stem cells(MSCs). We examined in vitro and in vivo effects of the internalization of Q-dots to MSCs, with using osteogenic, adipogenic, chondrogenic induction. In vitro results suggested negligible effect on each differentiation by the internalization, in vivo results indicated a long term tracking observation for over 8 weeks for bone regeneration model and over 24 weeks for cartilage regeneration model.
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