2012 Fiscal Year Final Research Report
Therapeutic strategy for the chronic pain through the neurogenesis of the central nervous system in enriched environment
| Project/Area Number |
21390431
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | University of Toyama |
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Principal Investigator |
YAMAZAKI Mitsuaki 富山大学, 大学院・医学薬学研究部(医学), 教授 (70158145)
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| Co-Investigator(Kenkyū-buntansha) |
NARITA Minoru 星薬科大学, 薬学部, 教授 (40318613)
HATAKEYAMA Noboru 愛知医科大学, 医学部, 教授 (70251907)
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| Project Period (FY) |
2009 – 2012
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| Keywords | neuropathic pain / enriched environment / neurogenesis / central nervous system |
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| Research Abstract |
Our results indicate that exposure to an enriched environment enhances neurogenesis and regulates emotionality. Enriched environment increases BDNF mRNA expression via sustained epigenetic modification in the mouse hippocampus. The chronic pain process promotes astrogliosis in the cingulate cortex through the dysfunction of cortical □-opioid receptors. Furthermore, chronic pain suppressed enriched environment mediated induction of both DCX- and NeuroD-labeled cells. These results suggest that chronic pain has stress-like damaging modulatory effects on hippocampal neurogenesis.
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[Journal Article] Upregulation of bradykinin receptors is implicated in the pain associated with caerulein-induced acute pancreatitis.2011
Author(s)
Takemura Y, Furuta S, Hirayama S, Miyashita K, Imai S, Narita M, Kuzumaki N, Tsukiyama Y, Yamazaki M, Suzuki T, Narita M
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Journal Title
Synapse
Volume: 65
Pages: 608-616
Peer Reviewed
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[Journal Article] Effects of gabapentin on brain hyperactivity related to pain and sleep disturbance under a neuropathic pain-like state using fMRI and brain wave analysis.2011
Author(s)
Takemura Y, Yamashita A, Horiuchi H, Furuya M, Yanase M, Niikura K, Imai S, Hatakeyama N, Kinoshita H, Tsukiyama Y, Senba E, Matoba M, Kuzumaki N, Yamazaki M, Suzuki T, Narita M.
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Journal Title
Synapse
Volume: 65
Pages: 668-676
Peer Reviewed
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[Journal Article] Enhancement of glutamatergic transmission in the cingulate cortex in response to mild noxious stimuli under a neuropathic pain-like state.2011
Author(s)
Niikura K, Furuya M, Narita M, Torigoe K, Kobayashi Y, Takemura Y, Yamazaki M, Horiuchi H, Enomoto T, Iseki M, Kinoshita H, Tomiyasu S, Imai S, Kuzumaki N, Suzuki T, Narita M.
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Journal Title
Synapse
Volume: 65
Pages: 424-432
Peer Reviewed
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[Journal Article] Direct evidence for the ongoing brain activation by enhanced dynorphinergic system in the spinal cord under inflammatory noxious stimuli.2010
Author(s)
Taketa Y, Niikura K, Kobayashi Y, Furuya M, Shimizu T, Narita M, Imai S, Kuzumaki N, Maitani Y, Yamazaki M, Inada E, Iseki M, Suzuki T, Narita M.
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Journal Title
Anesthesiology
Volume: 112
Pages: 418-431
Peer Reviewed
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