2011 Fiscal Year Final Research Report
Involvement of calcitonin gene-related peptide family in various pain states
| Project/Area Number |
21390432
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAMATA Tomoyuki 信州大学, 医学部, 准教授 (80336388)
TANAKA Satoshi 信州大学, 医学部附属病院, 講師 (60293510)
SHINDO Takayuki 信州大学, 医学系研究科, 教授 (90345215)
NARIMATSU Eichi 札幌医科大学, 医学部, 准教授 (70295343)
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| Project Period (FY) |
2009 – 2011
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| Keywords | CGRPファミリー / 血管新生 / CGRP / アドレノメデュリン |
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| Research Abstract |
We studied the involvement ofαCGRP in incisional pain model and inflammatory pain model by usingαCGRP knockout mice and CGRP receptor antagonist. Our study suggested that 1)αCGRP was involved in inflammatory pain but not in incisional pain model, 2)αCGRP was involved in spontaneous pain and thermal hyperalgesia in inflammatory pain model in the dorsal horn spinal cord, and 3)αCGRP was involved in some strong and long lasting pain. Thus, antagonists of CGRP receptors may be useful for some kinds of pain such as inflammatory pain.
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