2011 Fiscal Year Final Research Report
Cerebral and peripheral pathophysiology of delayed emotional disturbances associated with neuropathic pain
| Project/Area Number |
21390434
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Osaka University |
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Principal Investigator |
MASHIMO Takashi 大阪大学, 大学院・医学系研究科, 教授 (10110785)
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| Co-Investigator(Kenkyū-buntansha) |
SHIBATA Masahiko 大阪大学, 大学院・医学系研究科, 寄附講座教授 (50216016)
INOUE Takaya 大阪大学, 大学院・医学系研究科, 助教 (00335358)
SAKAUE Gaku 大阪大学, 大学院・医学系研究科, 助教 (70379254)
NAKAE Aya 大阪大学, 大学院・医学系研究科, 特任准教授(常勤) (60379170)
MATSUDA Yoichi 大阪大学, 大学院・医学系研究科, 助教 (00397754)
SUMITANI Masahiko 東京大学, 医学部附属病院, 助教 (80420420)
KITA Shinichi 神戸大学, 大学院・人文学研究科, 准教授 (10224940)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 神経障害性疼痛 / 情動異常 / α2Aアドレノ受容体 / モルヒネ耐性 / セロトニン2C受容体 / RNA編集 |
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| Research Abstract |
Nerve injury triggered affective disturbances such as depression and anxiety that appeared much later than sensory hypersensitivity in mice. The alpha-2A adrenergic receptor may play a role in the neural mechanism of affective disturbances. Systemic daily morphine enhanced the analgesic effect of intrathecal dexmedetomidine via up-regulation of the alpha-2A,-2B and-2C adrenergic receptors in lumber dorsal root ganglion and dorsal horn in mice. In the trigeminal neuropathic pain model rats, intrathecal serotonin 2C receptor agonists produced antiallodynic effect. This effect was attenuated by intrathecal pretreatment with the serotonin 2C receptor antagonist. These results indicate that the serotonin 2C receptor plays a role in spinal inhibition of trigeminal neuropathic pain
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[Journal Article] recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptor2010
Author(s)
Murray KC, Nakae A, Stephens MJ, Rank M, D' Amico J, Harvey PJ, Li X, Harris RLW, Ballou EW, Anelli R, Heckman CJ, Mashimo T, Vavrek R, Sanelli L, Gorassini MA, Bennett DJ, Fouad K
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Journal Title
Nature Med
Volume: 16
Pages: 694-700
Peer Reviewed
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