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2011 Fiscal Year Final Research Report

Analysis of the molecules of cell polarity in associated with hormone

Research Project

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Project/Area Number 21390443
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionYokohama City University

Principal Investigator

KUBOTA Yoshinobu  横浜市立大学, 医学研究科, 教授 (10106312)

Co-Investigator(Kenkyū-buntansha) UEMURA Hiroji  横浜市立大学, 附属病院, 准教授 (50244439)
NAGASHIMA Youji  横浜市立大学, 医学研究科, 准教授 (10217995)
AKIMOTO Kazunori  横浜市立大学, 医学部, 助教 (70285104)
Project Period (FY) 2009 – 2011
Keywords腫瘍学
Research Abstract

The mechanisms of developing hormone refractory prostate cancer(CRPC) remains unclear. We have provided the evidence that aPKCλ/ιexpression correlates with prostate cancer recurrence. Experiments in vitro and in vivo revealed aPKCλ/ιto be involved in prostate cancer cell growth through secretion of IL-6.And we further demonstrated a correlation between biochemical recurrence after prostatectomy and the expression of these two factors. These results support our hypothesis that aPKCλ/ιplay an important role in prostate cancer progression.

  • Research Products

    (17 results)

All 2011 2010 2009

All Journal Article (12 results) Presentation (5 results)

  • [Journal Article] The co-expression of aPKCλ/ιand IL-6 in prostate cancer tissue correlates with biochemical recurrence2011

    • Author(s)
      Ishiguro H, Akimoto K, Nagashima Y, Kagawa E, Sasaki T, Sano JY, Takagawa R, Fujinami K, Sasaki K, Aoki I, Ohno S, Kubota Y, Uemura H
    • Journal Title

      Cancer Science

      Volume: 102(8) Pages: 1576-81

  • [Journal Article] Identification of phosphorylated proteins involved in the oncogenesis of prostate cancer via Pin1-proteomic analysis2011

    • Author(s)
      Endoh K, Nishi M, Ishiguro H, Uemura H, Miyagi Y, Aoki I, Hirano H, Kubota Y, Ryo A
    • Journal Title

      The Prostate

  • [Journal Article] Regulation of androgen receptor expression through angiotensin II type 1 receptor in prostate cancer cells2011

    • Author(s)
      Hoshino K, Ishiguro H, Teranishi JI, Yoshida SI, Umemura S, Kubota Y, Uemura H
    • Journal Title

      The Prostate

      Volume: 71(9) Pages: 964-75

  • [Journal Article] Engagement of renin-angiotensin system in prostate cancer2011

    • Author(s)
      Uemura H, Hoshino K, Kubota Y
    • Journal Title

      Current Cancer Drug Targets

      Volume: 11(4) Pages: 442-450

  • [Journal Article] Contrast-enhanced ultrasonography of the prostate : various imaging findings that indicate prostate cancer2011

    • Author(s)
      Sano F, Terao H, Kawahara T, Miyoshi Y, Sasaki T, Noguchi K, Kubota Y, Uemura H
    • Journal Title

      BJU Intenational

      Volume: 107(9) Pages: 1404-10

  • [Journal Article] The potential of FDG-PET/CT for detecting prostate cancer in patients with an elevated serum PSA level2011

    • Author(s)
      Minamimoto R, Uemura H, Sano F, Terao H, Nagashima Y, Yamanaka S, Shizukuishi K, Tateishi U, Kubota Y, Inoue T
    • Journal Title

      Annals of Nuclear Medicine

      Volume: 25(1) Pages: 21-27

  • [Journal Article] Analysis of NSAID-activated gene 1 expression in prostate cancer2010

    • Author(s)
      Kawahara T, Ishiguro H, Hoshino K, Teranishi J, Miyoshi Y, Kubota Y, Uemura H
    • Journal Title

      Urologia Internationalis

      Volume: 84(2) Pages: 198-202

  • [Journal Article] High expression of atypical protein kinase C l/I in gastric cancer as a prognositic factor for recurrence2010

    • Author(s)
      Takagawa R, Akimoto K, Ichikawa Y, Akiyama H, Kojima Y, Ishiguro H, Inayama Y, Aoki I, Kunisaki C, Endo I, Nagashima Y, Ohno S
    • Journal Title

      Annals of Surgical Oncology

      Volume: 17(1) Pages: 81-88

  • [Journal Article] PKCλ/ιpromotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-62009

    • Author(s)
      Ishiguro H, Akimoto K, Nagashima Y, Kojima Y, Sasaki Y, Ishiguro-Imagawa Y, Nakaigawa N, Ohno S, Kubota Y, Uemura H
    • Journal Title

      Proceedings of the National Academy of Sciences(PNAS)

      Volume: 106(38) Pages: 16369-16374

  • [Journal Article] Avid F-18 FDG uptake in prostatic sarcoma2009

    • Author(s)
      Minamimoto R, Tateishi U, Uemura H, Yamanaka S, Kubota Y, Inoue T
    • Journal Title

      Clinical Nuclear Medicine

      Volume: 34(6) Pages: 388-389

  • [Journal Article] A cell polarity protein aPKClambda is required for eye lens formation and growth2009

    • Author(s)
      Sugiyama Y, Akimoto K, Robinson M. L, Ohno S, Quinlan R. A
    • Journal Title

      Dev Biol

      Volume: 336(2) Pages: 246-256

  • [Journal Article] An essential role of the universal polarity protein, aPKClambda, on the maintenance of podocyte slit diaphragms2009

    • Author(s)
      Hirose T, Satoh D, Kurihara H, Kusaka C, Hirose H, Akimoto K, Matsusaka T, Ichikawa I, Noda T, Ohno S
    • Journal Title

      PLoS ONE

      Volume: 4(1) Pages: e4194

  • [Presentation] Atypical protein kinase Cλ/ιregulates mouse mammary progenitor cell propagation2010

    • Author(s)
      Akimoto K, Zheng Y-W, Nagashima Y, Ishiguro H, Asai-Sato M, Kojima Y, Li B, Sasaki K, Kagawa E, Kim M, Taniguchi H, Noda T, and Ohno S
    • Organizer
      6th International Symposium on Hormonal Oncogenesis
    • Place of Presentation
      Tokyo
    • Year and Date
      20100912-16
  • [Presentation] Salvage radiotherapy for rising PSA after radical prostatectomy2010

    • Author(s)
      Iwasaki M, Uemura H, Nakaigawa N, Hayashi N, Ueno D, Makiyama K, Sano F, Sakata R, Noguchi G, Kawakami S, Hata M, Omura M, Inoue T, Kubota Y
    • Organizer
      The 20th Taiwan Urology Association Annual Meeting
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2010-11-13
  • [Presentation] In laterally spreading type tumors(LSTs) of the colon or the rectum, expression of the atypical protein kinase C lambda/iota is correlated to expression of beta-catenin and type IV collagen2010

    • Author(s)
      Ichikawa Y, Ishikawa T, Shimizu D, Goto A, Shimamura T, Suwa H, Tatsumi K, Watanabe K, Ota M, Fujii S, Kawamata M, Akimoto K, Nagashima Y, Takahashi H, Nakajima A, Ohno S, Endo I
    • Organizer
      The 102nd Annual Meeting of American Assiciation for Cancer Research,(Orland, FL)
    • Place of Presentation
      Orland, FL
    • Year and Date
      2010-09-22
  • [Presentation] Role of Renin-Angiotensin System in Prostate Cancer. Symposium "Angiotensin"2010

    • Author(s)
      Uemura H, Takahashi S, Hoshino K, Ishiguro H, Kubota Y
    • Organizer
      14th International Congress on Hormone Steroids and Hormones & Cancer
    • Place of Presentation
      Edinburgh, England
    • Year and Date
      2010-09-22
  • [Presentation] Deter mination of Androgens concentrations in prostate tissue taken by needle biopsy by LC/MS/MS. Preliminary study for diagnosis of malignancy from androgen level in prostate tissue2009

    • Author(s)
      Miyoshi Y, Umemoto S, Uemura H, Shibata Y, Arai S, Suzuki K, Honma S, Kubota Y
    • Organizer
      American Urological Association 104th Annual Meeting
    • Place of Presentation
      Chicago, USA
    • Year and Date
      20090425-30

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Published: 2013-07-31  

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