2011 Fiscal Year Final Research Report
Analysis of the molecules of cell polarity in associated with hormone
Project/Area Number |
21390443
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Urology
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Research Institution | Yokohama City University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
UEMURA Hiroji 横浜市立大学, 附属病院, 准教授 (50244439)
NAGASHIMA Youji 横浜市立大学, 医学研究科, 准教授 (10217995)
AKIMOTO Kazunori 横浜市立大学, 医学部, 助教 (70285104)
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Project Period (FY) |
2009 – 2011
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Keywords | 腫瘍学 |
Research Abstract |
The mechanisms of developing hormone refractory prostate cancer(CRPC) remains unclear. We have provided the evidence that aPKCλ/ιexpression correlates with prostate cancer recurrence. Experiments in vitro and in vivo revealed aPKCλ/ιto be involved in prostate cancer cell growth through secretion of IL-6.And we further demonstrated a correlation between biochemical recurrence after prostatectomy and the expression of these two factors. These results support our hypothesis that aPKCλ/ιplay an important role in prostate cancer progression.
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[Journal Article] The co-expression of aPKCλ/ιand IL-6 in prostate cancer tissue correlates with biochemical recurrence2011
Author(s)
Ishiguro H, Akimoto K, Nagashima Y, Kagawa E, Sasaki T, Sano JY, Takagawa R, Fujinami K, Sasaki K, Aoki I, Ohno S, Kubota Y, Uemura H
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Journal Title
Cancer Science
Volume: 102(8)
Pages: 1576-81
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[Journal Article] High expression of atypical protein kinase C l/I in gastric cancer as a prognositic factor for recurrence2010
Author(s)
Takagawa R, Akimoto K, Ichikawa Y, Akiyama H, Kojima Y, Ishiguro H, Inayama Y, Aoki I, Kunisaki C, Endo I, Nagashima Y, Ohno S
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Journal Title
Annals of Surgical Oncology
Volume: 17(1)
Pages: 81-88
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[Journal Article] An essential role of the universal polarity protein, aPKClambda, on the maintenance of podocyte slit diaphragms2009
Author(s)
Hirose T, Satoh D, Kurihara H, Kusaka C, Hirose H, Akimoto K, Matsusaka T, Ichikawa I, Noda T, Ohno S
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Journal Title
PLoS ONE
Volume: 4(1)
Pages: e4194
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[Presentation] Atypical protein kinase Cλ/ιregulates mouse mammary progenitor cell propagation2010
Author(s)
Akimoto K, Zheng Y-W, Nagashima Y, Ishiguro H, Asai-Sato M, Kojima Y, Li B, Sasaki K, Kagawa E, Kim M, Taniguchi H, Noda T, and Ohno S
Organizer
6th International Symposium on Hormonal Oncogenesis
Place of Presentation
Tokyo
Year and Date
20100912-16
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[Presentation] Salvage radiotherapy for rising PSA after radical prostatectomy2010
Author(s)
Iwasaki M, Uemura H, Nakaigawa N, Hayashi N, Ueno D, Makiyama K, Sano F, Sakata R, Noguchi G, Kawakami S, Hata M, Omura M, Inoue T, Kubota Y
Organizer
The 20th Taiwan Urology Association Annual Meeting
Place of Presentation
Taipei, Taiwan
Year and Date
2010-11-13
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[Presentation] In laterally spreading type tumors(LSTs) of the colon or the rectum, expression of the atypical protein kinase C lambda/iota is correlated to expression of beta-catenin and type IV collagen2010
Author(s)
Ichikawa Y, Ishikawa T, Shimizu D, Goto A, Shimamura T, Suwa H, Tatsumi K, Watanabe K, Ota M, Fujii S, Kawamata M, Akimoto K, Nagashima Y, Takahashi H, Nakajima A, Ohno S, Endo I
Organizer
The 102nd Annual Meeting of American Assiciation for Cancer Research,(Orland, FL)
Place of Presentation
Orland, FL
Year and Date
2010-09-22
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