2011 Fiscal Year Final Research Report
Down regulation of antigen presentation pathway plays an important role in metastasis and progression of advanced stage of epithelial ovarian cancer.
| Project/Area Number |
21390449
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAHATA Tetsuro 新潟大学, 医歯学系, 准教授 (90293232)
YOSHIHARA Kousuke 新潟大学, 医歯学系, 助教 (40547535)
SEKINE Masayuki 新潟大学, 医歯学総合病院, 助教 (70345502)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 卵巣がん / EMT / 抗原提供 / 遺伝子発現プロファイル |
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| Research Abstract |
High-grade serous ovarian cancers are heterogeneous not only in terms of clinical outcome but also at the molecular level. Our aim was to establish a novel risk classification system based on a gene expression signature for predicting overall survival, leading to suggesting novel therapeutic strategies using EMT molecules for high-risk patients. This risk classification based on the gene expression signature is an accurate predictor of clinical outcome in patients with advanced stage high-grade serous ovarian cancer and has the potential to develop new therapeutic strategies for high-grade serous ovarian cancer patients.
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