Disruption of the blood-labyrinthine barrier and related genes in sudden sensorineural hearing loss

2012 Fiscal Year Final Research Report

• Project/Area Number: 21390460
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Nagoya University
• Principal Investigator: NAKASHIMA Tsutomu 名古屋大学, 医学系研究科, 教授 (30180277)
• Co-Investigator(Kenkyū-buntansha): NAGANAWA Shinji 名古屋大学, 大学院・医学系研究科, 教授 (50242863) ; SHIMOKATA Hiroshi 国立長寿医療センター, 国立長寿医療センター研究所, 疫学研究部長 (10226269) ; TERANISHI Masaaki 名古屋大学, 大学院・医学系研究科, 講師 (20335037)
• Co-Investigator(Renkei-kenkyūsha): UCHIDA Yasue 愛知医科大学, 医学部, 講師 (80313998)
• Project Period (FY): 2009 – 2012
• Keywords: 突発性難聴 / 血液迷路関門 / MRI / 遺伝子多型

Research Abstract

Disruption of the blood-labyrinthine barrier was evaluated by the degree of Gd contrast enhancement of the inner ear in suddensensorineural hearing loss. There were ears with significant Gd enhancenment but there were also ears without Gd enhancement. Disruption of the blood-labyrinthine barrier may be associated with impairment of the blood vessels, inflammation and oxidative stress. The relevant gene polymorphisms were investigated in patients with sudden sensorineural hearing loss and in controls. Polymorphisms of interleukin-1A (rs1800587), interleukin-6 (rs1061170), complement factor H (rs1061170), aquaporin5 (rs3736309) and NO synthase 3 (rs1799983) seemed to be related to onset of sudden sensorineural hearing loss.交付決定額

Research Products

• [Journal Article] Polymorhisms in genes involved in the free-radical process in patients with sudden sensorineural hearing loss and Meniere's disease. (2013)
  • Author(s): Teranishi M, Uchida Y, Nishio N, Kato K, Otake H, Yoshida T, Suzuki H, Sone M, Sugiura S, Ando F, Shimokata H, Nakashima T.
  • Journal Title: Free Radic Res Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Magnetic resonance imaging of the inner ear after both intratympanic and intravenous gadolinium injections. (2013)
  • Author(s): Iida T, Teranishi M, Yoshida T, Otake H, Sone M, Kato M, Shimono M, Yamazaki M, Naganawa S, Nakashima T.
  • Journal Title: Acta Otolaryngol Volume: 133 Pages: 434-438
  • Peer Reviewed
• [Journal Article] Polymorphisms in genes encoding aquaporins 4 and 5 and estrogen receptor α in patients with Meniere's disease and sudden sensorineural hearing loss. (2013)
  • Author(s): Nishio N, Teranishi M, Uchida Y, Sugiura S, Ando F, Shimokata H, Sone M, Otake H,Kato K, Yoshida T, Tagaya M, Hibi T, Nakashima T.
  • Journal Title: Life Sci Volume: 92 Pages: 541-546
  • Peer Reviewed
• [Journal Article] Contrast enhancement of the inner ear in magnetic resonance images taken at 10 minutes or 4 hours after intravenous gadolinium injection. (2012)
  • Author(s): Sano R, Teranishi M, Yamazaki M, Isoda H, Naganawa S, Sone M, Hiramatsu M, Yoshida T, Suzuki H, Nakashima T.
  • Journal Title: Acta Otolaryngol Volume: 132 Pages: 241-246
  • Peer Reviewed
• [Journal Article] Polymorphisms in Genes Involved in Oxidative Stress Response in Patients with Sudden Sensorineural Hearing Loss and Meniere's Disease in a Japanese Population. (2012)
  • Author(s): Teranishi M, Uchida Y, Nishio N, Kato K, Otake H, Yoshida T, Suzuki H, Sone M, Sugiura S, Ando F, Shimokata H, Nakashima T.
  • Journal Title: DNA Cell Biol Volume: 31 Pages: 1555-1562
  • Peer Reviewed
• [Journal Article] Polymorphisms in Genes Involved in Inflammatory Pathways in Patients with Sudden Sensorineural Hearing Loss. (2012)
  • Author(s): Hiramatsu M, Teranishi M, Uchida Y, Nishio N, Suzuki H, Kato K, Otake H, Yoshida T, Tagaya M, Suzuki H, Sone M, Sugiura S, Ando F, Shimokata H, Nakashima T.
  • Journal Title: J Neurogenet. Volume: 26 Pages: 387-396
  • Peer Reviewed
• [Journal Article] Contribution of complement factor H Y402H polymorphism to sudden sensorineural hearing loss risk and possible interaction with diabetes. (2012)
  • Author(s): Nishio N, Teranishi M, Uchida Y, Sugiura S, Ando F, Shimokata H, Sone M, Otake H, Kato K, Yoshida T, Tagaya M, Hibi T, Nakashima T.
  • Journal Title: Gene Volume: 499(1) Pages: 226-230
  • Peer Reviewed
• [Journal Article] Association of interleukin-1 gene polymorphisms with sudden sensirineral hearing loss and Meniere's disease (2011)
  • Author(s): Furuta T, Teranishi M, Uchida Y, Nishio N, Kato K, Otake H, Yoshida T, Tagaya M, Suzuki H, Sugiura M, Sone M, Hiramatsu M, Sugiura S, Ando F, Shimokata H, Nakashima T.
  • Journal Title: Int Journal Immunogenet Volume: 38 Pages: 249-254
  • Peer Reviewed
• [Journal Article] 3 Tesla magnetic resonance imaging obtained 4 hours after intravenous gadolinium injection in patients with sudden deafness (2010)
  • Author(s): Tagaya M, Teranishi M, Naganawa S, Iwata T, Yoshida T, Otake H, Nakata S, Sone M, Nakashima T.
  • Journal Title: Acta Otolaryngol Volume: 130 Pages: 665-669
  • Peer Reviewed
• [Presentation] Magnetic resonance imaging of the inner ear after intratympanic and intravenous gadolinium injections (2012)
  • Author(s): Nakashima T, Iida T, Teranishi M, Yoshida T, Kato M, Sone M, Yamazaki M, Naganawa S.
  • Organizer: 49th Inner Ear Bioloby Workshop
  • Place of Presentation: Tubingen, Germany
  • Year and Date: 20120930-1002
• [Presentation] Polymorphic analysis in patients with Meniere's disease and sudden sensorineural hearing loss (2012)
  • Author(s): Teranishi M, Uchida Y, Nishio N, Kao K, Otake H, Yoshida T, Sone M, Sugiura S, Ando F, Shimokata H, Nakashima T.
  • Organizer: 49th Inner Ear Bioloby Workshop
  • Place of Presentation: Tubingen, Germany
  • Year and Date: 20120930-1002
• [Presentation] Polymorphisms in genes involved in inflammatory pathways in patients with sudden sensorineural hearing loss (2011)
  • Author(s): Teranishi M, Hiramatsu M, Uchida Y, Nishio N, Suzuki H, Kato K, Otake H, Yoshida T, Tagaya M, Suzuki H, Sone M, Sugiura S, Ando F, Shimokata H, Nakashima T.
  • Organizer: 48th Inner Ear Biology Workshop
  • Place of Presentation: Lisbon, Portugal
  • Year and Date: 20110918-21
• [Presentation] Contribution of complement factor H Y402H polymorphism to sudden sensorineural hearing loss risk and possible interaction with diabetes (2011)
  • Author(s): Nishio N, Teranishi M, Uchida Y, Sugiura S, Ando F, Shimokata H, Sone M, Otake H, Kato K, Yoshida T, Tagaya M, Hibi T, Nakashima T.
  • Organizer: 11th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2011-12-08
• [Book] 「紹介の最適のタイミングは?」急性難聴の鑑別とその対処 (2012)
  • Author(s): 寺西正明、中島務
  • Total Pages: 232-235
  • Publisher: 中山書店
• [Book] 「予後診断は可能か?」 急性難聴の鑑別とその対処 (2012)
  • Author(s): 寺西正明、中島務
  • Total Pages: 229-232
  • Publisher: 中山書店
• [Remarks] ホームページ等 (研究代表者 Researcher ID)
  • URL: http://www.researcherid.com/rid/B-8259-2012