2012 Fiscal Year Final Research Report
New treatment using gene induction and regenerative medicinefor diaphragmatic agenesis
| Project/Area Number |
21390475
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pediatric surgery
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MASUMOTO Koji 筑波大学, 医学医療系, 教授 (20343329)
NONAKA Kazuaki 九州大学, 歯学研究院, 教授 (90128067)
NAGATA Koji 九州大学, 大学病院, 助教 (20419568)
IEIRI Satoshi 九州大学, 大学病院, 講師 (00363359)
TAJIRI Tatsuro 京都府立医科大学, 医学研究科, 教授 (80304806)
KINOSHITA Yoshiaki 九州大学, 医学研究院, 准教授 (80345529)
|
|---|
| Project Period (FY) |
2009 – 2012
|
| Keywords | 小児呼吸器外科学 / 横隔膜ヘルニア / 肺低形成 / 成長因子 |
|---|
| Research Abstract |
Intrapulmonary mesenchymal stem cells (MSC) were administered to the rat with nitrophen-induced diaphragmatic hernia. As a result, PCNA positive cells are increased.DNA was extracted from the 20 patients and parents of congenital diaphragmatic hernia. The microdeletion of TCTE3 was detected. This might be the responsible gene for congenital diaphragmatic hernia.Abdominal muscle flap method was performed for the reconstructive surgery in 11 cases with recurrent diaphragmatic hernia. All of the patients showed good outcome.Liver-like cells were induced from SHED. We are just starting to make the sheet of the striated muscle cells derived from SHED.
|
