2011 Fiscal Year Final Research Report
Role of retinoic acid in the mechanism of skin wound healing
| Project/Area Number |
21390480
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
SAKAI Yasuo 大阪大学, 医学系・研究科, 准教授 (50272315)
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| Co-Investigator(Kenkyū-buntansha) |
ITAMT Satoshi 大阪大学, 医学系・研究科, 寄附講座教授 (30136791)
KISHI Kazuo 慶應義塾大学, 医学部, 教授 (40224919)
YOSHIMURA Yoko 藤田保健衛生大学, 医学部, 教授 (20129737)
INOUE Yoshikazu 藤田保健衛生大学, 医学部, 助教 (80340264)
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| Project Period (FY) |
2009 – 2011
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| Keywords | レチノイン酸 / 皮膚発生 / 毛発生 / 創傷治癒 / CYP26B1 |
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| Research Abstract |
We searched for a role of retinoic acid(RA) in the developmental skin using Cyp26b1 knockout(KO) mice. A skin barrier dysfunction was observed in the Cyp26b1-KO epidermis. We found malformation in the cornified layer and absence of keratohyaline granules in the granular layer. Krtap13, a marker of the periderm, was also up-regulated and last in later stages. Although the Cyp26b1-KO skin lacked hair follicles, skin grafting to a nude mouse could induce hair formation. We performed fetal operation to know the effect of RA on wound healing. In the Cyp26b1-KO skin, a delay of healing was seen compared with the normal one. In this study, we found RA is critical for skin development and wound healing.
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