2011 Fiscal Year Final Research Report
Myeloid-associated immunoglobulin-like receptors, CD300 are promising antibody-therapeutic targets for sepsis
| Project/Area Number |
21390481
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
TAHARA Satoko 筑波大学, 医学医療系, 助教 (20360589)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 救急蘇生学 / 敗血症 / 抗体療法 / CD300a / CD300d |
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| Research Abstract |
An appropriate activation of innate immune responses is crucial for control microbe infection. An excessive activation and dysfunction of innate immune responses leads to onset of sepsis. To elucidate the regulatory mechanism of innate immune responses is critical for establish the therapeutic approaches for sepsis. We have recently identified myeloid-associated immunoglobulin-like receptors, such as MAIR-I (CD300a) and MAIR-II (CD300d), and found that these receptors are crucial for regulating innate immune responses. Furthermore, administration of a monoclonal antibody against MAIR-I prolonged the survival of mice after cecal ligation and puncture (CLP)-induced sepsis.
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