2011 Fiscal Year Final Research Report
Hyperglycemia-induced alterations of gut microflora and therapeutic strategy in a critically ill model
| Project/Area Number |
21390484
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AI Kimiaki 慶應義塾大学, 医学部, 助教 (30265847)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 高血糖 / 敗血症 / 腸管関連リンパ組織 / 炎症性サイトカイン / 腸管壁防御機構 / 腸内細菌 / リンパ球サブセット |
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| Research Abstract |
In this study, we examined if persistent hyperglycemia elicited alterations of gut barrier function in a critical ill model. Short-term hyperglycemia augmented gut mucosal permeability in an endotoxemic model, while long-term hyperglycemia for 24hr resulted in the up-regulation of inflammatory cytokines such as IL-1β and IL-6 in mesenteric lymph nodes, and of T lymphocyte subset such as helper T2 and regulatory T cells in gut. The present study shed light on the significant effects of clinically relevant level of persistent hyperglycemia on gut barrier function and immune system in critical ill.
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