2011 Fiscal Year Final Research Report
Elucidation of autophagy in development of periodontitis and its application of therapy
| Project/Area Number |
21390496
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
TSUKUBA Takayuki 長崎大学, 大学院・医歯薬学総合研究科, 教授 (30264055)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Kuniaki 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (10311846)
NISHISHITA Kazuhisa 長崎大学, 大学院・医歯薬学総合研究科, 助教 (20237697)
SAKAI Eiko 長崎大学, 大学院・医歯薬学総合研究科, 助教 (10176612)
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| Project Period (FY) |
2007 – 2011
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| Keywords | オートファジー / カテプシン / リソソーム関連遺伝子 / 歯周病 / 歯周病原性細菌 |
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| Research Abstract |
Various genetic disorders in severe periodontitis are caused by abnormalities of lysosomal-related genes. However, the detailed mechanisms are still unknown. Recently, we have assumed that autophagy is involved in elimination of Porphyromonas gingivalis, a major periodontal pathogen, after infection. In this study, we have elucidated the detailed mechanisms of autophagy in periodontitis, an important issue of dental science, in order to provide clues to the molecular basis of new methods for prevention, diagnosis, and therapy in oral sciences.
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