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2012 Fiscal Year Final Research Report

An experimental study for developments of a 4D-imaging system and a novel gene therapy for the hemangioma using nanobubbles and ultrasound

Research Project

  • PDF
Project/Area Number 21390500
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionTohoku University

Principal Investigator

SAKAMOTO Maya  東北大学, 病院, 講師 (90157686)

Co-Investigator(Kenkyū-buntansha) IIKUBO Masahiro  東北大学, 大学院・歯学研究科, 講師 (80302157)
MORI Shiro  東北大学, 病院, 講師 (80230069)
Co-Investigator(Renkei-kenkyūsha) KODAMA Tetsuya  東北大学, 医工学研究科, 教授 (40271986)
ONO Masao  東北大学, 医学系研究科, 教授 (20302218)
KOJIMA Ikuho  東北大学, 大学院・歯学研究科, 助教 (80447169)
SASANO Takashi  東北大学, 大学院・歯学研究科, 教授 (10125560)
Project Period (FY) 2009 – 2012
Keywordsナノバブル / 超音波 / 血管腫 / 遺伝子治療
Research Abstract

The aim of the present study is to develop a diagnostic imaging system and gene therapy system for hemangioma using nanobubbles and ultrasound. In the present study, by using experimental tumor model, we developed a high-resolution diagnostic imaging system utilizing nanobubbles and high-frequency ultrasound image analysis equipment. In addition, we were able to present the possibility of a new gene therapy method for hemangioma by transfer of a plasmid DNA, which inhibited the tumor growth, by utilizing nanobubbles and ultrasound.

  • Research Products

    (48 results)

All 2013 2012 2011 2010 2009

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (34 results) Book (2 results)

  • [Journal Article] Enhancedsonographic imaging to diagnose lymph node metastasis: importance of bloodvessel volume and density2013

    • Author(s)
      Li Li, Mori S, Kodama M, Sakamoto M, Takahashi S, KodamaT
    • Journal Title

      Cancer Reseach

      Volume: 73 Pages: 2082-2092

    • DOI

      doi:10.1158/0008-5472.CAN-12-4200

    • Peer Reviewed
  • [Journal Article] Mouse model of lymph nodemetastasis via afferent lymphatic vessels for development of imaging modalities2013

    • Author(s)
      Li Li, Mori S, Sakamoto M, Takahashi S, Kodama T
    • Journal Title

      PLOS ONE

      Volume: 8

    • DOI

      Doi:10.1371/joumal.pone.0055797

    • Peer Reviewed
  • [Journal Article] Correct diagnosis of Warthin tumor in the parotid gland with dynamic MRI2012

    • Author(s)
      Ogawa T, Suzuki T, Sakamoto M, Watanabe M, Tateda Y, Oshima T, Kato K, Sagai S, Kobayashi Tu, Shiga K
    • Journal Title

      Tohoku J Exp Med

      Volume: 227 Pages: 53-57

    • DOI

      Doi:10.1620/tjem.227.53

    • Peer Reviewed
  • [Journal Article] Difficulty of the differential diagnosis of basal cell adenoma and basal cell adenocarcinoma of parotid gland by magnetic resonance imaging: case reports and literature review2012

    • Author(s)
      Kojima I, Sakamoto M, Watanabe M,Takahashi S, Mugikura S, Shiga K, Iikubo M, Yamamura MJ, Sasano T.
    • Journal Title

      Oral Radiol

      Volume: 28 Pages: 24-31

    • DOI

      Doi:10.1007/s11282-011-0076-7

    • Peer Reviewed
  • [Journal Article] Morphological and histopathological changes on orofacial sturucture of experimentally developed acromegaly-like rats: An Overview2012

    • Author(s)
      Iikubo M, Kojima I, Sakamoto M, Kobayashi A, Ikeda H, Sasano T.
    • Journal Title

      Int J Endocrinol

      Pages: 254367

    • DOI

      doi:10.1155/2012/254367

    • Peer Reviewed
  • [Journal Article] Volumetric and angiogenic evaluation of antitumor effects with acoustic liposome and high-frequency ultrasound2011

    • Author(s)
      Kodama T, Tomita N, Yagishita Y, Horie S, Funamoto K, Hayase T, Sakamoto M, Mori S.
    • Journal Title

      Cancer Res

      Volume: 71 Pages: 6957-6964

    • DOI

      doi:10.1158/0008-5472.CAN-11-2389

    • Peer Reviewed
  • [Journal Article] Evaluation of anti-tumor effects following tumor necrosis factor-alpha gene delivery usingnanobubbles and ultrasound2011

    • Author(s)
      Horie S, Watanabe Y, Ono M, Mori S, Kodama T.
    • Journal Title

      Cancer Sci

      Volume: 102 Pages: 2082-2089

    • Peer Reviewed
  • [Journal Article] Development of localized gene delivery using a dual-intensity ultyrasound system in the bladder2010

    • Author(s)
      Horie S, Watabnabe Y, Chen R, Mori S, Matsumura Y, Kodama T
    • Journal Title

      Ultrasound Med Biol

      Volume: 36(11) Pages: 1867-1875

    • Peer Reviewed
  • [Journal Article] Evaluation of transfection efficiency in skeletal muscle using nano/microbubbles and ultrasound2010

    • Author(s)
      Kodama T, Aoi A, Watabnabe Y, Horie S, Kodama M, Li L, Chen R, Teramoto N, Morikawa H, Mori S, Fukumoto M
    • Journal Title

      Ultrasound Med Biol

      Volume: 36(7) Pages: 1196-1205

    • Peer Reviewed
  • [Journal Article] Evaluating the Role of Rheumatoid Factors for the Development of Rheumatoid Arthritis in a Mouse Model with a Newly Established ELISA System2010

    • Author(s)
      Tanaka Y, Komori H, Mori S, Soga Y, Tsubaki T, Terada M, Miyazaki T, FujinoT, Nakamura S, Kanno H, Sawasaki T, Endo Y, Nose M
    • Journal Title

      Tohoku J Exp Med

      Volume: 220 (3) Pages: 199-206

    • Peer Reviewed
  • [Journal Article] Morphological study on Acoustic liposome using transmission electron microscopy2010

    • Author(s)
      Kodama T, Tomita N, Horie S, Sax N, Iwasaki H, Suzuki R, Maruyama K, Mori S, Fukumoto M
    • Journal Title

      J Electron Microsc

      Volume: 59(3) Pages: 187-196

    • Peer Reviewed
  • [Journal Article] Accuracy of Intra-oral Radiology, Multi-detector Herical CT and LimitedCone Beam CT for the Detevtion of Horizontal Tooth Root Fracture2009

    • Author(s)
      Iikubo M, Kobayashi K, Mishima A, Shimoda S, Daimaruya T, Igarashi C, Imanaka M, Yuasa M, Sakamoto M, Sasano T.
    • Journal Title

      Oral SWurg Oral Med Oral Pathol Oral Radiol Endod

      Volume: 108 Pages: 70-74

    • Peer Reviewed
  • [Presentation] プラズモン共鳴を利用した局所的熱療法のリンパ節転移治療への応用2012

    • Author(s)
      奥野竜希,長谷川奈保,畠山友梨子,加藤茂樹,阪本真弥,森士朗,小玉哲也
    • Organizer
      日本バイオマテリアル学会大会シンポジウム2012
    • Place of Presentation
      仙台
    • Year and Date
      20121126-27
  • [Presentation] 乳がんにおける腫瘍周辺上皮組織リンパ管および血管分布に関する研究2012

    • Author(s)
      三浦由宣, 佐藤琢磨, 阪本真弥, 森士朗, 小玉哲也
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      20120919-21
  • [Presentation] 二光子顕微鏡をもちいたEPR効果による腫瘍内ナノ粒子流出特性の観察2012

    • Author(s)
      三ヶ田護, サックスニコラ, 阪本真弥, 森士朗, 小玉哲也
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      20120919-21
  • [Presentation] Pressure-driven flow characteristics in the lymphatic vessel for lymphatic drug delivery ststem2012

    • Author(s)
      Hatakeyama Y, Sax N, Kato S, Okuno T, Sakamoto M, Nori S, Kodama T
    • Organizer
      The 9th International Conference on Flow Dynamics. Proceedings
    • Place of Presentation
      Sendai, Japan.
    • Year and Date
      20120919-21
  • [Presentation] Cancer treatment via the lymphatic vessel using nano/microbubbles2012

    • Author(s)
      Kato S, Nicolas S, Hatakeyama Y, OkunoT, Mori S, Sakamoto M, Kodama T
    • Organizer
      The 9th International Conference on Flow Dynamics
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      20120919-21
  • [Presentation] Thermal therapy using plasmonic nano particles for lymph node metastasis2012

    • Author(s)
      Okuno T, Kato S, Hatakeyama Y, Sato T, Sakamoto M, Mori S, Kodama T
    • Organizer
      The 9th International Conference on Flow Dynamics
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      20120919-21
  • [Presentation] リンパ行性薬剤送達システムの開発2012

    • Author(s)
      畠山友梨子, 李麗, サックスニコラ, 奥野竜希, 加藤茂樹, 阪本真弥, 森士朗, 小玉哲也
    • Organizer
      日本機械学会2012年度年次大会
    • Place of Presentation
      金沢
    • Year and Date
      20120909-12
  • [Presentation] 腫瘍の成長にともなう鼠径リンパ節内の間質液圧特性に関する研究2012

    • Author(s)
      三浦由宣,畠山友梨子,阪本真弥,森士朗,小玉哲也
    • Organizer
      日本機械学会2012年度年次大会
    • Place of Presentation
      金沢
    • Year and Date
      20120909-12
  • [Presentation] 腫瘍移植とEPR効果に関する研究2012

    • Author(s)
      三ヶ田護,サックスニコラ,阪本真弥,森士朗,小玉哲也
    • Organizer
      日本機械学会2012年度年次大会
    • Place of Presentation
      金沢
    • Year and Date
      20120909-12
  • [Presentation] Drug delivery system with acoustic liposomes via the lymphatic vessels2012

    • Author(s)
      Kato S, Horie S, Sakamoto M, Mori S, Kodama T
    • Organizer
      The 8th InternationalSymposium on Cavitation
    • Place of Presentation
      Singapore
    • Year and Date
      20120813-16
  • [Presentation] サックスニコラ, 奥野竜希, 森士朗, 阪本真弥, 小玉哲也: リンパ行性薬剤送達システム開発のためのリンパ節およびリンパ管内の流動特性2012

    • Author(s)
      畠山梨友子
    • Organizer
      第28回日本DDS学会
    • Place of Presentation
      札幌
    • Year and Date
      20120704-05
  • [Presentation] シェーグレン症候群における顎下腺および舌下腺のMRIと診断学的意義について2012

    • Author(s)
      阪本真弥、小嶋郁穂、酒井梓、佐藤恭子、菅原由美子、佐藤しづ子、飯久保正弘、笹野高嗣
    • Organizer
      第53回日本歯科放射線学会総会
    • Place of Presentation
      盛岡
    • Year and Date
      20120601-03
  • [Presentation] Effectsof the liposomal formuilation on the behavior and physical characteristics of acoustic liposomes2012

    • Author(s)
      Sax N, Horie S, Li L, Li S, Kochi T, Chen R, Watanabe Y, Yagishita Y, Sakamoto M, Mori S, Kodam T
    • Organizer
      The 19th International Symposium on Nonliner Acoustics
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      20120521-24
  • [Presentation] Flow characteristics of the lymphatic flow to the axillary lymph node driven by increasing pressures in the inguinallymph node2012

    • Author(s)
      Hatakeyama Y, Nicolas S, Li L, Kato S,Okuno T, Miura Y, Shao L, Sakamoto M, Mori S, Fujikawa S, Kodama T
    • Organizer
      Medical Physics andBiomedical Engineering
    • Place of Presentation
      Beijing, China
    • Year and Date
      20120326-31
  • [Presentation] Clinical surver of dentin hypersensitivity-like toothache induced by steroid therapy2012

    • Author(s)
      Endo Y, Iikubo M, Shoji M, Ishii T, Harigae H, Sakamoto M, Sasano T.
    • Organizer
      AADR Annual Meeting
    • Place of Presentation
      Tampa,USA
    • Year and Date
      20120321-23
  • [Presentation] 鼠径リンパ節内の圧力上昇にともなう輸出リンパ管への流出特性2011

    • Author(s)
      畠山友梨子,李麗,サックスニコラ,阪本真弥,森士朗,小玉哲也
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      20111003-05
  • [Presentation] 唾液腺腫瘍のMRI-腫瘍鑑別における被膜様増強効果の意義について-2011

    • Author(s)
      阪本真弥,飯久保正弘,小嶋郁穂,志賀清人,高橋昭喜,笹野高嗣
    • Organizer
      日本歯科放射線学会第16回臨床画像大会
    • Place of Presentation
      新潟
    • Year and Date
      20111001-02
  • [Presentation] 頭頸部癌遺伝子治療に向けたナノバブルと超音波によるNIS遺伝子導入と^<124>I-PETイメージング2011

    • Author(s)
      渡邊夕紀子,森士朗,堀江佐知子,サックスニコラ,李麗,李深偉,柳下陽子,高地崇,船木善仁,菊池洋平,山崎浩道,石井慶造,阪本真弥,宮下仁,小玉哲也
    • Organizer
      第35回日本頭頸部癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      20110609-10
  • [Presentation] 頭頸部癌所属リンパ節転移の診断・治療に向けたリンパ節腫大マウスを用いたリンパ節転移モデルの開発2011

    • Author(s)
      李麗,森士朗,柳下陽子,サックスニコラ,堀江佐知子,渡邊夕紀子,高地崇,李深偉,宮下仁,森川秀広,阪本真弥,小玉哲也
    • Organizer
      第35回日本頭頸部癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      20110609-10
  • [Presentation] Characteristics of acinic cell carcinoma of the parotid gland on MR imaging2011

    • Author(s)
      Sakamoto M, Kojima I, Iikubo M, Yamamura MJ, Mugikura S, Takahashi S,Ogawa T, Shiga K, Watanabe M, Sasano T.
    • Organizer
      The 18th International Congress of Dento-Maxillo-Facial Radiology
    • Place of Presentation
      Hiroshima,Japan
    • Year and Date
      20110325-29
  • [Presentation] マイクロバブル造影剤と超音波を用いた頭頸部癌症例の頸部リンパ節転移の検討2010

    • Author(s)
      天野雅紀,志賀清人,加藤健吾,小川武則,小林俊光,小玉哲也,阪本真弥
    • Organizer
      第48回日本癌治療学会
    • Place of Presentation
      京都
    • Year and Date
      20101028-30
  • [Presentation] 膀胱がん治療に向けた二重超音波照射法の数値的至適化2010

    • Author(s)
      小島貴則,堀江佐知子,渡邊夕紀子,陳鋭,李麗,阪本真弥,森士朗,小玉哲也
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      20100922-24
  • [Presentation] Longitudinal three-dementional noninvasive imaging analysis and quantification of anti-tumor effectsof TNF-alpha gene for small tumor2010

    • Author(s)
      Horie S, Watanabe Y, Yagishita Y, Sax N, Chen R, Li L, Kojima T, Morikawa H, Sakamoto M, Ono S, Mori S, Kodama T.
    • Organizer
      The World Molecular Imaging Congress
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      20100908-11
  • [Presentation] 唾液腺腫瘍のMRI誤診しやすい悪性腫瘍2010

    • Author(s)
      阪本真弥,志賀清人,小嶋郁穂,飯久保正弘,笹野高嗣,高橋昭喜
    • Organizer
      第15回日本歯科放射線学会臨床画像大会
    • Place of Presentation
      鹿児島
    • Year and Date
      20100903-05
  • [Presentation] Development and characterization of achogenic pogylated liposomes2010

    • Author(s)
      SaxN,HorieS,LiL,ChenR,WatanabeY,MoriS,SakamotoM,KodamaT.
    • Organizer
      第26回日本DDS学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20100617-18
  • [Presentation] ナノバブルと高周波超音波を用いた画像診断システムに関する研究第1報微小腫瘍の診断精度に関する検討.NPO法人日本歯科放射線学会2010

    • Author(s)
      阪本真弥,小嶋郁穂,森士朗,山村宗正,飯久保正弘,笹野高嗣
    • Organizer
      第51回学術大会
    • Place of Presentation
      鶴見
    • Year and Date
      20100423-25
  • [Presentation] ナノバブルと高周波超音波を用いた画像診断システムに関する研究第2報悪性腫瘍の治療にともなう腫瘍内血管密度の変化.NPO法人日本歯科放射線学会2010

    • Author(s)
      小嶋郁穂,阪本真弥,森士朗,山村宗正,飯久保正弘,笹野高嗣
    • Organizer
      第51回学術大会
    • Place of Presentation
      鶴見
    • Year and Date
      20100423-25
  • [Presentation] Volumetric and angiogenetic imagingsystem by using nanobubbles and high-frequency ultrasound for evaluation of the antitumor effect by cisplatin2010

    • Author(s)
      Yagishita Y, Takata Y, Ohki K, Miyashita H, Morikawa H, Sakamoto M, Mori S, Kawamura H , Kodama T.
    • Organizer
      The 5th International Symposium on Medical, Bio- and Nano-Electronics. Book of Abstract.161-162
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      20100224-25
  • [Presentation] Four-dimensional high-frequency ultrasound imaging system for early detection of lymph node micro-metastasis2010

    • Author(s)
      Li L, Horie S, Rui Chen, Watanabe Y, Baba T, Sax N, Sakamoto M, Mori S, Takahashi S, Kodama T.
    • Organizer
      The 5th International Symposium on Medical, Bio- and Nano-Electronics. Book of Abstract
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      20100224-25
  • [Presentation] Ultrasound molecular imaging of lymph node metastasis with nano/microbubbles2010

    • Author(s)
      Li L, Chen R, Horie S, Watanabe Y, Baba T, Sax N, Sakamoto M, Mori S, Takahashi S, Kodama T.
    • Organizer
      International Symposium of AIDS and Tuberculosis (ISAT2010)
    • Place of Presentation
      Sendai,Japan
    • Year and Date
      20100113-14
  • [Presentation] マイクロバブルと高周波超音波を用いた三次元イメージング法による転移リンパ節の血管密度の評価2010

    • Author(s)
      佐藤祥太,李麗,柳下陽子,阪本真弥,高橋昭喜,森士朗,小玉哲也
    • Organizer
      日本超音波医学会東北地方会第40回学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2010-09-26
  • [Presentation] Thee-dimentional high-frequency ultrasound imaging for early diagnosis of lymph node metastasis combined with microbubbles2009

    • Author(s)
      Li L, Horie S, Chen R, Watanabe Y, Sakamoto M, Mori S, Takahashi S, Kodama T.
    • Organizer
      The 3rd East Asian Pacific Student Workshop on Nano-Biomedical Engineering
    • Place of Presentation
      Singapore
    • Year and Date
      20091221-22
  • [Presentation] 超音波分子イメージングによるリンパ節転移早期診断法の開発2009

    • Author(s)
      李麗,堀江佐知子,陳鋭,渡邊夕紀子,阪本真弥,森士朗,小玉哲也
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      20091003-05
  • [Presentation] ダイナミックMRIで多形腺腫を診断するポイント.NPO法人日本歯科放射線学会2009

    • Author(s)
      阪本真弥,飯久保正弘麦倉俊司,日向野修一,高橋昭喜,志賀清人,小嶋郁穂,笹野高嗣
    • Organizer
      第50回学術大会
    • Place of Presentation
      大阪
    • Year and Date
      20090528-30
  • [Book] 口腔外科ハンドマニュアル'112011

    • Author(s)
      阪本真弥・笹野高嗣
    • Total Pages
      120-126
    • Publisher
      クインテッセンス出版株式会社
  • [Book] 口腔画像臨床診断学2010

    • Author(s)
      阪本真弥・笹野高嗣
    • Total Pages
      232-239
    • Publisher
      アークメディア社

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Published: 2014-08-29  

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