2011 Fiscal Year Final Research Report
What is required for periodontal ligament regeneration?
| Project/Area Number |
21390510
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Hidefumi 九州大学, 大学病院, 講師 (10284514)
WADA Naohisa 九州大学, 大学病院, 講師 (60380466)
TOMOKIYO Atsushi 九州大学, 大学院・歯学研究院, 助教 (20507777)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 歯内療法学 |
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| Research Abstract |
As periodontal ligament(PDL) is a fibrous connective tissue connecting tooth root to bone, it plays an important role in retaining tooth. In this research, we aimed to identify stem cells, signaling elements, and scaffolds suitable for the regeneration of PDL tissue that is severely damaged by deep caries, serious periodontitis, and trauma. Here we report that for PDL stem cells, the cells expressing the same markers as mesenchymal stem cell basically meet the criteria of PDL stem cells ; as candidates suitable as signaling elements, TGF-beta1, bFGF, serial treatment of TGF-beta1 after bFGF, NGF, GDNF, EGF, mechanical stress, Angiotensin II, Interleukin-11, and calcium are enumerated ; materials including calcium and the resin such as Superbond showed efficacy as scaffolds for PDL stem cells.
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