2011 Fiscal Year Final Research Report
Bisphosphonate-induced jawbone necrosis : studies for its mechanism, prevention, and treatment
| Project/Area Number |
21390529
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
ENDO Yasuo 東北大学, 大学院・歯学研究科, 大学院非常勤講師 (50005039)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAGUCHI Kouji 東北大学, 大学院・歯学研究科, 大学院非常勤講師 (10372319)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ビスフォスフォネート / 顎骨壊死 / 骨吸収抑制薬 / 炎症 / 壊死 / 薬物副作用 |
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| Research Abstract |
Bisphosphonates(BPs)are widely used as anti-bone-resorptive drugs, and nitrogen-containing BPs(NBPs)are much more powerful than non-nitrogen-containing BPs(non-NBPs). However, NBPs have inflammatory and necrotic side effects including jawbone necrosis. We have discovered that the non-NBPs etidronate and clodronate lack such side effects. On the contrary, they can prevent or reduce the NBPs'side effects. During the period of this project, we could accumulate many findings concerning the mechanisms underlying the NBPs'side effects and non-NBPs' protective effects and the effects of their combination on bone. In addition, we noted that the non-NBPs have a potent analgesic effect(lacked in NBPs and independent of their anti-bone-resorptive effects). Based on these findings, we propose that(i)etidronate and clodronate can be used as a substitution drug to NBPs and a combination drug with an NBP, respectively, and(ii)they warrant reappraisal as safe drugs for osteoporosis.
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[Journal Article] Inhibition of necrotic actions of nitrogen-containing bisphosphonates(NBPs)and their elimination from bone by etidronate(a Non-NBP): a proposal for possible utilization of etidronate as a substitution drug for NBPs2010
Author(s)
Takefumi Oizumi, Hiromi Funayama, Kouji Yamaguchi, Masayoshi Yokoyama, Harue Takahashi, Miou Yamamoto, Toshinobu Kuroishi, Hiroyuki Kumamoto, Keiichi Sasaki, Hiroshi Kawamura, Shunji Sugawara, Yasuo Endo
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Journal Title
J Oral Maxillofacial Surgery
Volume: 68
Pages: 1043-1054
Peer Reviewed
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