2011 Fiscal Year Final Research Report

A novel method for inhibiting cancer metastasis and invasion by regulating the Lin7C-CASK-βcatenin-network.

Research Project

Project/Area Number	21390531
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	Surgical dentistry
Research Institution	Chiba University
Principal Investigator	SAKAMOTO Yosuke 千葉大学, 医学部・附属病院, 助教 (50451745)
Co-Investigator(Kenkyū-buntansha)	SAKAMOTO Yosuke 千葉大学, 医学部附属病院, 助教 (50451745) TANZAWA Hideki 千葉大学, 大学院・医学研究院, 教授 (50236775)
Project Period (FY)	2009 – 2011
Keywords	浸潤転移能 / Lin7C-CASK-βcateninネットワーク / HTR2C遺伝子
Research Abstract	The aim of this study was to develop a new method of inhibiting the invasion and metastasis of oral squamous cell carcinoma (OSCC) through the activating Lin7C-CASK-βcatenin (LCB) pathway. In Lin7C-overexpressed OSCC cells, CASK andβcatenin levels are significantly higher than that in Mock-transfected cells. In addition, we identified HTR2C in some molecules of upstream of LCB pathway by the Ingenuity Pathway Analysis. We demonstrated that the specific HTR2C inhibitor closely related to LCB pathway, and therefore might be a therapeutic tool for cancer invasion and metastasis.