2011 Fiscal Year Final Research Report
Development on scaffold-free 3D regenerative cartilage as surgical implants
| Project/Area Number |
21390532
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HOSHI Kazuto 東京大学, 医学部附属病院, 特任准教授 (30344451)
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| Co-Investigator(Kenkyū-buntansha) |
TAKATO Tsuyoshi 東京大学, 医学部附属病院, 教授 (90171454)
MORI Yoshiyuki 東京大学, 医学部附属病院, 准教授 (70251296)
FUJIHARA Yuko 東京大学, 医学(系)研究科(研究院), 特任助教 (50466744)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 再生軟骨 / インプラント / スカフォールド / 顎顔面 / 軟骨細胞 |
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| Research Abstract |
We have produced complex regenerative cartilage or regenerative joints that consist of two layers of cartilage and bone to apply them to the repair of cleft lip-nose or temporomandibular joint reconstruction. Regarding every regenerative cartilage which we have invented, a large amount of cell pellets were produced, and then physical strength and resistance to hypoxia or undernutrition were added to them. After that, 3D shape was formed by accumulating and fusing those pellets together. At transplantation, tissue tension relief was attempted in the transplantation site. Based on the techniques, we have realized scaffold-free 3D regenerative cartilage.
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[Journal Article] Selection of highly osteogenic and chondrogenic cells from bone marrow stromal cells in biocompatible polymer-coated plates2010
Author(s)
Liu G, Iwata K, Ogasawara T, Watanabe J, Fukazawa K, Ishihara K, Asawa Y, Fujihara Y, Chung UL, Moro T, Takatori Y, Takato T, Nakamura K, Kawaguchi H, Hoshi K
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Journal Title
J Biomed Mater Res A
Volume: 92(4)
Pages: 1265-1272
Peer Reviewed
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[Journal Article] Effects of transforming growth factor(TGF)-b1 in combination with fibroblast growth factor(FGF)-2 and insulin-like growth factor(IGF)-I on chondrocytes proliferation culture for the cartilage regenerative medicine2009
Author(s)
Ogasawara T, Ohba S, Fujihara Y, Takahashi T, Liu G, Chikazu D, Suenaga H, Chung U, Yoda T, Mori Y, Susami T, Takato T, Hoshi K
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Journal Title
Asian Journal of Oral and Maxillofacial Surgery
Volume: 21
Pages: 18-26
Peer Reviewed
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[Journal Article] Nanog promotes osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2 by modulating bone morphogenetic protein(BMP) signaling
Author(s)
Ogasawara T, Ohba Shinsuke, Yano F, Kawaguchi H, Chung UI, Saito T, Yonehara Y, Nakatsuka, T, Mori Y, Takato T, Hoshi K
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Journal Title
J Cell Physiol
Volume: (In press)
Peer Reviewed
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[Journal Article] Recent trends of cartilage regenerative medicine and its application to the oral and maxillofacial surgery
Author(s)
Hoshi K, Fujihara Y, Asawa Y, Nishizawa S, Kanazawa S, Sakamoto T, Watanabe M, Ogasawara T, H S, Mori Y, Takato T
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Journal Title
Oral Science International
Volume: (In press)
Peer Reviewed
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[Presentation] Development of implant-type tissue-engineered cartilage applied for the nasal correction of the cleft lip and palate patients2011
Author(s)
Kazuto Hoshi, Yuko Fujihara, Satoru Nishizawa, Yukiyo Asawa, Sanshiro Kanazawa, Makoto Watanabe, Tomoaki Sakamoto, Ryoko Inaki, Misaki Takei, Mariko Matsuyama, Sakura Uto, Kumiko Kurabayashi, Toru Ogasawara,* Satoru Nagata, Tsuyoshi Takato
Organizer
9th European Craniofacial Congress
Place of Presentation
Salzburg, Austria
Year and Date
20110914-17
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[Presentation] DEVELOPMENT OF IMPLANT-TYPE TISSUE-ENGINEERED CARTILAGE APPLIED FOR THE CORRECTION OF THE CLEFT LIP-NOSE PATIENTS2011
Author(s)
K. Hoshi, Y. Fujihara, S. Nishizawa, Y. Asawa, S. Kanazawa, M. Watanabe, T. Sakamoto, R. Inaki, M. Takei, M. Matsuyama, S. Uto, K. Kurabayashi, M, Harai, T. Ogasawara, S. Nagata, T. Takato
Organizer
TERMIS-AP 2011
Place of Presentation
Singapore
Year and Date
20110803-05
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