2011 Fiscal Year Final Research Report
Bone regeneration procedure with tongue muscle-derived stem cell
| Project/Area Number |
21390540
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Yamaguchi University |
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Principal Investigator |
UEYAMA Yoshiya 山口大学, 大学院・医学系研究科, 教授 (00168668)
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| Co-Investigator(Kenkyū-buntansha) |
HARADA Koji 山口大学, 大学院・医学系研究科, 助教 (60253217)
ITASHIKI Yasutaka 山口大学, 医学部附属病院, 医員 (70530236)
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| Project Period (FY) |
2009 – 2011
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| Keywords | マウス舌筋由来幹細胞 / 分化誘導 / 骨再生 / β-TCPゼラチンスポンジ |
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| Research Abstract |
Tongue muscle-derived Sca-1 positive cells(TDSCs) were isolated from Jcl-ICR mice tongue muscle by magnetic cell separation system with microbeads. TDSCs differentiated to osteoblast lineage demonstrated by up-regulation of osteoblastic makers and formation of mineralized matrix with alizarin red or Von Kossa positive in vitro. The bone formation was observed in the gelatin sponges ofβ-TCP. These data suggest that TDSCs retain its osteogenic differentiation potential, and may be useful for regenerative medicine of bone.
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