2011 Fiscal Year Final Research Report
Isolation and identification of oral cancer stem cells and development of specific therapy for cancer stem cells
| Project/Area Number |
21390544
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NOGUCHI Kazuma 兵庫医科大学, 医学部, 講師 (50309473)
HASHITANI Susumu 兵庫医科大学, 医学部, 助教 (00330449)
KISHIMOTO Hiromitsu 兵庫医科大学, 医学部, 准教授 (30291818)
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| Research Collaborator |
SEGAWA Emi 兵庫医科大学, 医学部, 助教 (00553778)
ZUSHI Yuusuke 兵庫医科大学, 医学部, 助教 (80581206)
HIROMOTO Takashi 兵庫医科大学, 医学部, 大学院生
YAMAMURA Michiyo 兵庫医科大学, 医学部, 大学院生
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| Project Period (FY) |
2009 – 2011
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| Keywords | 臨床腫瘍学 |
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| Research Abstract |
The aim of this study is to isolate and identify oral cancer stem cells(CSC) that are considered to be involved in tumor recurrence and metastasis, and to develop the therapy specific for CSC. Various cultured oral squamous carcinoma cells contained SP cells that are included in side population and considered CSC, in 0.04.0.4% of total cell population. The ratio included had a tendency to be increased in cancer cells overexpressing cyclooxygenase-2, cisplatin-resistant cancer cells expressing multidrug resistance gene MDR-1, and cancer cells showing poor differentiation and high invasiveness. There is a possibility to find out a clue for specific therapy by using these CSC-like cells.
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