2011 Fiscal Year Final Research Report
Study of cementogenesis and Wnt signaling
| Project/Area Number |
21390552
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
NEMOTO Eiji 東北大学, 大学院・歯学研究科, 准教授 (40292221)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMAUCHI Hidetoshi 東北大学, 大学院・歯学研究科, 教授 (70187425)
TAMURA Masato 北海道大学, 大学院・歯学研究科, 教授 (30236757)
TADA Hiroyuki 東北大学, 大学院・歯学研究科, 大学院非常勤講師 (70431632)
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| Project Period (FY) |
2009 – 2011
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| Keywords | Wntシグナル / セメント芽細胞 / 細胞分化 |
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| Research Abstract |
Wnts are secreted glycoproteins that mediate developmental and post-developmental physiology through canonical and noncanonic al pathway. Although it appears that Wnt5a signaling supports normal bone physiology, the biological significa nce of noncanonical Wnts in osteogenesis is essentially unknown. In this study, we identified the expression of Wnt5a in osteoblasts in the tibial growth plate as well as bone marrow of rat tibia. Silencing gene expression of Wnt5a in cultured pre-osteobla st cells results in suppression of osteoblastic differen tiation, suggesting that Wnt5a signaling are of substantial importance for osteoblastic differentiation.
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