2011 Fiscal Year Final Research Report
A fundamental study regarding the cultured periosteum and its scaffold leading to a novel periodontal regenerative treatment
| Project/Area Number |
21390554
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWASE Tomoyuki 新潟大学, 医歯学系, 准教授 (90191999)
KOGAMI Hiroyuki 新潟大学, 医歯学系, 助教 (10463978)
NAGATA Masaki 新潟大学, 医歯学総合病院, 講師 (10242439)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 歯周組織 / 再生医学 / 細胞治療 / 再生骨膜 / 細胞培養 / 生体材料 / 基材 / 硬組織評価 |
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| Research Abstract |
A novel periodontal regenerative treatment using autologous cultured periosteal sheet with an osteogenic property attracts attention nowadays.
We examined the cell-biological characteristics of this sheet and the reaction of various scaffolding materials to this biological sheet through in vitro and in vivo experiments. It was suggested that cultured periosteal sheet has stem cell-like cells, and has a possibility to express osteogenic property by induction of cell differentiation. Cell adhesion was improved by making processing some treatment on the surface of high molecular or inorganic scaffolding materials, and was able to support a cell migration and calcification.
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Research Products
(47 results)
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[Journal Article] Collagen-coated poly(L-lactide-co-ε-caprolactone) film : A promising scaffold for cultured periosteal sheets2010
Author(s)
Kawase T, Yamanaka K, Suda Y, Kaneko T, Okuda K, Kogami H, Nakayama H, Nagata M, (他2名、1, 5, 6, 8番目)
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Journal Title
Periodontol
Volume: 81(11)
Pages: 1653-1662
Peer Reviewed
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[Presentation] An osteogenic grafting complex composed of human periosteal sheet and its scaffolding material, a porous poly(L-lactic acid) membrane : biocompatibility, biodegradation, and cell fate in vivo2011
Author(s)
Kawase T, Tanaka T, Nishimoto T, Okuda K, Nagata M(他2名、1, 4, 5番目)
Organizer
Tissue Engineering & Regenerative Medicine International Society 2011 Asia Pacific Meeting
Place of Presentation
Grand Copthome Warwefront Hotel, Singapore
Year and Date
2011-08-04
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[Presentation] Non-invasive evaluation of the osteogenic activity of alveolar bone-derived human periosteal sheets in animal implantation models by in vivo near-infrared(NIR) optical imaging2010
Author(s)
Kawase T, Nakayama H, Okuda K, Kogami H, Nagata M,(他2名、1, 3, 4, 5番目)
Organizer
The 96th Annual Meeting of the American Academy of Periodontology
Place of Presentation
Honolulu, HI, USA
Year and Date
2010-11-01
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[Presentation] The human cultured periosteal sheet for periodontal regeneration : a salmon collagen. coated mesh, a functionally potent scaffold, to upregulate the osteogenic potential2009
Author(s)
Okuda K, Kawase T, Kogami H, Nakayama H, Nagata M(他1名、1, 2, 3, 5番目)
Organizer
The 95th Annual Meeting of the American Academy of Periodontology
Place of Presentation
Boston, MA, USA
Year and Date
2009-09-01
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