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2009 Fiscal Year Annual Research Report

認知症の早期診断と社会対策の最先端研究および国際最新状況に関する海外調査研究

Research Project

Project/Area Number 21404002
Section海外学術
Research InstitutionOkayama University

Principal Investigator

呉 景龍  Okayama University, 大学院・自然科学研究科, 教授 (30294648)

Co-Investigator(Kenkyū-buntansha) 峠 哲男  香川大学, 工学部, 教授 (80197839)
福山 秀直  京都大学, 医学研究科, 教授 (90181297)
高橋 智  岡山大学, 大学院・自然科学研究科, 准教授 (20236277)
Keywords認知症 / 早期診断 / 脳波 / 画像診断 / fMRI / 視覚 / 聴覚 / 触覚
Research Abstract

代表者と分担者は海外研究者(医学出身と工学出身)と国内研究者(院生を含む)の協力を得て,アジア、アメリカなどの地域への現地訪問および通信調査などの手段を用いて,(1)海外での認知症調査研究,(2)認知症診断技術の国際基準の提案,(3)認知症社会対策の提言に関する調査を行った.本研究の調査研究では,中国(北京大学、中国医科大学、上海交通大学など),米国(Sun Health Research Institute、Arizona State Universityなど),韓国(KAISTなど)などの研究機関と連絡を取り,調査研究を行った.
平成21年度の調査研究では,(a)認知科学的手法による早期診断技術,(b)脳波・径頭蓋磁気刺激による波形診断技術,(c)医用画像による画像診断技術の3課題に対して,研究代表者と分担者を中心に研究協力者を加えたグループを編成し,調査研究を行った.具体的には,(a)で視覚刺激,聴覚刺激,触覚刺激に対する健康高齢者と認知症患者の違いについての調査,(b)で刺激呈示時の脳波について調べた研究結果,診断例の調査,(c)ではfMRIなどの脳画像を用いた認知症早期診断技術に関する調査をそれぞれ行った.得られた調査研究結果をまとめ,一部については岡山大学医学部で臨床実験を行い,診断手法の有効性について見当を行っているところである.得られた研究成果は認知症病理メカニズムの解明、認知症早期診断国際基準への提案に必要となる関連データを提供する。
本年度の調査,実験において明らかになった問題点,研究項目については,平成22年度以降に実施する第2回調査研究において引き続き進行する.

  • Research Products

    (45 results)

All 2010 2009

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (33 results) Book (1 results)

  • [Journal Article] Audiovisual interaction enhances auditory detection in late stage : an event-related potential study2010

    • Author(s)
      Qi Li
    • Journal Title

      NeuroReport 21(3)

      Pages: 173-178

    • Peer Reviewed
  • [Journal Article] An autopsy case of Creutzfeldt-Jakob disease with a V180I mutation of the PrP gene and Alzheimer-type pathology.2010

    • Author(s)
      Yoshida H
    • Journal Title

      Neuropathology (Epub ahead of print)

    • Peer Reviewed
  • [Journal Article] Investigation on Human Visual and Auditory Calculation Mechanism by Event Related Potential2010

    • Author(s)
      Jinglong Wu
    • Journal Title

      INFORMATION 13(1)

      Pages: 99-109

    • Peer Reviewed
  • [Journal Article] Reversible Alcohol-related Dementia : A Five-year Follow-up Study Using FDG-PET and Neuropsychological Tests2010

    • Author(s)
      Asada T.
    • Journal Title

      INTERNAL MEDICINE 49

      Pages: 283-287

    • Peer Reviewed
  • [Journal Article] 動的視野加齢効果の計測と交通安全への適用に関する検討2009

    • Author(s)
      呉景龍
    • Journal Title

      IATSS Review 34(3)

      Pages: 63-71

    • Peer Reviewed
  • [Journal Article] Multisensory Interactions Elicited by Audiovisual Stimuli Presented Peripherally in a Visual Attention Task : A Behavioral and Event-Related Potential Study in Humans2009

    • Author(s)
      Jinglong Wu
    • Journal Title

      Journal of Clinical Neurophysilogy 26(6)

      Pages: 407-413

    • Peer Reviewed
  • [Journal Article] Multisensory Interactions of Audiovisual Stimuli Presented at Different Location in Visual-Attention Tasks2009

    • Author(s)
      Qi Li
    • Journal Title

      INFORMATION 12(6)

      Pages: 1311-1320

    • Peer Reviewed
  • [Journal Article] キュー刺激を用いた視覚と聴覚の空間能動注意時及び時間能動注意時の脳活動の比較 : fMRI研究2009

    • Author(s)
      呉景龍
    • Journal Title

      電子情報通信学会論文誌 J92-A(9)

      Pages: 633-643

    • Peer Reviewed
  • [Journal Article] Measurement and Analysis of Binocular Perceptual Characteristics with Peripheral Vision for the Development of Head Mounted Display with Wide View2009

    • Author(s)
      Xiaoguang Li
    • Journal Title

      INFORMATION 12(3)

      Pages: 621-640

    • Peer Reviewed
  • [Journal Article] Paraneoplastic necrotizing myelopathy in a patient with advanced esophageal cancer : An autopsied case report.2009

    • Author(s)
      Urai Y.
    • Journal Title

      Journal of Neurological Sciences 280(1-2)

      Pages: 113-117

    • Peer Reviewed
  • [Journal Article] 最大随意的筋収縮時の磁気刺激法が運動ニューロン興奮性に与える影響2009

    • Author(s)
      峠哲男
    • Journal Title

      臨床脳波 51(1)

      Pages: 6-11

    • Peer Reviewed
  • [Presentation] 認知症の脳機能画像-最近の話題-2010

    • Author(s)
      福山秀直
    • Organizer
      第20回福井県脳機能画像カンファレンス
    • Place of Presentation
      福井県福井市
    • Year and Date
      2010-03-05
  • [Presentation] A Study on Motion Recognition of Hand using Surface EMG of Forearm for Upper-Limb Rehabilitation2009

    • Author(s)
      Kazuya Funada
    • Organizer
      2009 International Symposium on Early Detection and Rehabilitation Technology of Dementia(DRD2009)
    • Place of Presentation
      Okayama, Japan
    • Year and Date
      2009-12-12
  • [Presentation] Development of a New Rehabilitation Device for Hand Movement Disorder2009

    • Author(s)
      Akia Gyoten
    • Organizer
      2009 International Symposium on Early Detection and Rehabilitation Technology of Dementia(DRD2009)
    • Place of Presentation
      Okayama, Japan
    • Year and Date
      2009-12-12
  • [Presentation] Investigation on human characteristic on sound source localization under the masking in median and frontal plane for early detection of dementia2009

    • Author(s)
      Kouji Nagashima
    • Organizer
      2009 International Symposium on Early Detection and Rehabilitation Technology of Dementia(DRD2009)
    • Place of Presentation
      Okayama, Japan
    • Year and Date
      2009-12-12
  • [Presentation] Measurement on Human Kinetic Visual Field with Changing Contrast and Brightness2009

    • Author(s)
      Hidenori Hiraki
    • Organizer
      2009 International Symposium on Early Detection and Rehabilitation Technology of Dementia(DRD2009)
    • Place of Presentation
      Okayama, Japan
    • Year and Date
      2009-12-12
  • [Presentation] A bilateral cortical network for Chinese character processing : An fMRI study2009

    • Author(s)
      Xiujun Li
    • Organizer
      2009 International Symposium on Early Detection and Rehabilitation Technology of Dementia(DRD2009)
    • Place of Presentation
      Okayama, Japan
    • Year and Date
      2009-12-12
  • [Presentation] Development of neurorehabilitation techniques using transcranial magnetic stimulation with voluntary muscle contraction2009

    • Author(s)
      Tetsuo Touge
    • Organizer
      2009 International Symposium on Early Detection and Rehabilitation Technology of Dementia(DRD2009)
    • Place of Presentation
      Okayama, Japan
    • Year and Date
      2009-12-12
  • [Presentation] Functional optical hemodynamic imaging of the olfactory cortex in patients with Parkinson's disease2009

    • Author(s)
      Eiji Kobayashi
    • Organizer
      2009 International Symposium on Early Detection and Rehabilitation Technology of Dementia(DRD2009)
    • Place of Presentation
      Okayama, Japan
    • Year and Date
      2009-12-12
  • [Presentation] Neuroimaging in Alzheimer's disease2009

    • Author(s)
      Hidenao Fukuyama
    • Organizer
      2009 International Symposium on Early Detection and Rehabilitation Technology of Dementia(DRD2009)
    • Place of Presentation
      Okayama, Japan
    • Year and Date
      2009-12-12
  • [Presentation] An international investigation about driving license for dementia patient with social surroundings2009

    • Author(s)
      Satoshi Takahashi
    • Organizer
      2009 International Symposium on Early Detection and Rehabilitation Technology of Dementia(DRD2009)
    • Place of Presentation
      Okayama, Japan
    • Year and Date
      2009-12-11
  • [Presentation] Development of a New Four-degree-of freedom Length Display Device for Cognitive Science Experiment and Rehabilitation2009

    • Author(s)
      Noritsugu Kitayama
    • Organizer
      2009 International Symposium on Early Detection and Rehabilitation Technology of Dementia(DRD2009)
    • Place of Presentation
      Okayama, Japan
    • Year and Date
      2009-12-11
  • [Presentation] Development of a Tactile Pattern Delivery Device to Investigate Cognitive Mechanisms of Tactile Angle Discrimination2009

    • Author(s)
      Takashi Ogasa
    • Organizer
      2009 International Symposium on Early Detection and Rehabilitation Technology of Dementia(DRD2009)
    • Place of Presentation
      Okayama, Japan
    • Year and Date
      2009-12-11
  • [Presentation] Effects of modality-specific selective attention on audiovisual integration2009

    • Author(s)
      Qi Li
    • Organizer
      2009 International Symposium on Early Detection and Rehabilitation Technology of Dementia(DRD2009)
    • Place of Presentation
      Okayama, Japan
    • Year and Date
      2009-12-11
  • [Presentation] Investigation of Neuronal Substrates for Language Processing, Using Word Priming2009

    • Author(s)
      Chunlin Li
    • Organizer
      2009 International Symposium on Early Detection and Rehabilitation Technology of Dementia(DRD2009)
    • Place of Presentation
      Okayama, Japan
    • Year and Date
      2009-12-11
  • [Presentation] Investigation on visual voluntary spatial attention with and without auditory crossmodal stimulus2009

    • Author(s)
      Shuo Zhao
    • Organizer
      2009 International Symposium on Early Detection and Rehabilitation Technology of Dementia(DRD2009)
    • Place of Presentation
      Okayama, Japan
    • Year and Date
      2009-12-11
  • [Presentation] Location and Functional Subsivision of Human Visual Motion Organization MT+ used functional Magnetic Resonance Imaging2009

    • Author(s)
      Tianyi Yan
    • Organizer
      2009 International Symposium on Early Detection and Rehabilitation Technology of Dementia(DRD2009)
    • Place of Presentation
      Okayama, Japan
    • Year and Date
      2009-12-11
  • [Presentation] 抗NMDAR抗体陽性辺縁系脳炎の1例における高次脳機能の検討2009

    • Author(s)
      池田和代
    • Organizer
      第87回日本神経学会中国・四国地方会
    • Place of Presentation
      香川県高松市
    • Year and Date
      2009-12-05
  • [Presentation] 事象開連電位を用いた周辺視野における聴覚刺激による視覚注意への影響に関する検討2009

    • Author(s)
      李奇
    • Organizer
      第39回日本臨床神経生理学会学術大会
    • Place of Presentation
      福岡県北九州市
    • Year and Date
      2009-11-20
  • [Presentation] Multimodal interaction elicited by audiovisual stimuli presented centrally in a divided attention task : An event-related potential study in humans2009

    • Author(s)
      Qi Li
    • Organizer
      The Fifth International Conference on Information
    • Place of Presentation
      京都
    • Year and Date
      2009-11-09
  • [Presentation] Multisensory Interaction of Audiovisual Stimuli on the Central and Peripheral Spatial Locations2009

    • Author(s)
      Qi Li
    • Organizer
      2009 International Conference on Active Media Technology and Brain Informatics
    • Place of Presentation
      Beijing, China
    • Year and Date
      2009-10-24
  • [Presentation] Human Characteristics on Length Peception with Three Fingers for Tactile Intelligent Interfaces2009

    • Author(s)
      Haibo Wang
    • Organizer
      2009 International Conference on Active Media Technology and Brain Informatics
    • Place of Presentation
      Beijing, China
    • Year and Date
      2009-10-24
  • [Presentation] Correlated Size Variations Measured in Human Visual Cortex V1/V2/V3 with functional MRI2009

    • Author(s)
      Tianyi Yan
    • Organizer
      2009 International Conference on Active Media Technology and Brain Informatics
    • Place of Presentation
      Beijing, China
    • Year and Date
      2009-10-23
  • [Presentation] Neuronal substrates of nonword priming effect : an fMRI study2009

    • Author(s)
      Chunlin Li
    • Organizer
      2009 International Conference on Active Media Technology and Brain Informatics
    • Place of Presentation
      Beijing, China
    • Year and Date
      2009-10-22
  • [Presentation] 認知症の機能画像2009

    • Author(s)
      福山秀直
    • Organizer
      第17回北和神経内科研究会プログラム
    • Place of Presentation
      奈良県天理市
    • Year and Date
      2009-10-15
  • [Presentation] Investigation of neuronal substrates for language processing, using word priming2009

    • Author(s)
      Chunlin Li
    • Organizer
      2009 IEEE International Conference on Mechatronics and Automation
    • Place of Presentation
      Chang Chun, China
    • Year and Date
      2009-08-10
  • [Presentation] Central versus peripheral retinotopic and temporal frequency sensitivities of human visual areas measured using fMRI2009

    • Author(s)
      Tianyi Yan
    • Organizer
      2009 IEEE International Conference on Mechatronics and Automation
    • Place of Presentation
      Chang Chun, China
    • Year and Date
      2009-08-10
  • [Presentation] Multisensory Interactions of Audiovisual Stimuli Presented at Different Locations in Auditory-Attention Tasks : A Event-related Potential(ERP)Study2009

    • Author(s)
      Qi Li
    • Organizer
      2009 IEEE International Conference on Mechatronics and Automation
    • Place of Presentation
      Chang Chun, China
    • Year and Date
      2009-08-10
  • [Presentation] Processing of Chinese Characters and pure tones in literate and illiterate subjects : An auditory fMRI study2009

    • Author(s)
      Xiujun Li
    • Organizer
      2009 IEEE International Conference on Mechatronics and Automation
    • Place of Presentation
      Chang Chun, China
    • Year and Date
      2009-08-10
  • [Presentation] Excitability changes of corticospinal pathways by magnetic brain stimulation during the maximum voluntary muscle contraction2009

    • Author(s)
      Touge Tetsuo
    • Organizer
      2009 IEEE/ICME International Conference on Complex Medical Engineering(CME2009)
    • Place of Presentation
      Arizona, U.S.A
    • Year and Date
      2009-04-10
  • [Presentation] The Influence of Spatial Congruency on Audiovisual Interaction in a Visual-attention Task2009

    • Author(s)
      Qi Li
    • Organizer
      2009 IEEE/ICME International Conference on Complex Medical Engineering(CME2009)
    • Place of Presentation
      Arizona, U.S.A
    • Year and Date
      2009-04-09
  • [Presentation] Development of a Dual Tactile Pattern Presentation Device using in MRI Enviroment2009

    • Author(s)
      Jiajia Yang
    • Organizer
      2009 IEEE/ICME International Conference on Complex Medical Engineering(CME2009)
    • Place of Presentation
      Arizona, U.S.A
    • Year and Date
      2009-04-09
  • [Presentation] Tactile Perception of Two Length by Precision Griping with Tree Forefingers2009

    • Author(s)
      Haibo Wang
    • Organizer
      2009 IEEE/ICME International Conference on Complex Medical Engineering(CME2009)
    • Place of Presentation
      Arizona, U.S.A
    • Year and Date
      2009-04-09
  • [Presentation] Differences during character and figure processing in Chinese literates and illiterates : A visual fMRI2009

    • Author(s)
      Xiugun Li
    • Organizer
      2009 IEEE/ICME International Conference on Complex Medical Engineering(CME2009)
    • Place of Presentation
      Arizona, U.S.A
    • Year and Date
      2009-04-09
  • [Book] 神経医工学-脳神経科学・工学・情報科学の融合-2009

    • Author(s)
      呉景龍
    • Total Pages
      295
    • Publisher
      オーム社

URL: 

Published: 2011-06-16   Modified: 2016-04-21  

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