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2011 Fiscal Year Annual Research Report

認知症の早期診断と社会対策の最先端研究および国際最新状況に関する海外調査研究

Research Project

Project/Area Number 21404002
Research InstitutionOkayama University

Principal Investigator

呉 景龍  岡山大学, 大学院・自然科学研究科, 教授 (30294648)

Co-Investigator(Kenkyū-buntansha) 峠 哲男  香川大学, 医学部, 教授 (80197839)
福山 秀直  京都大学, 大学院・医学研究科, 教授 (90181297)
高橋 智  岡山大学, 大学院・自然科学研究科, 准教授 (20236277)
楊 家家  岡山大学, 大学院・自然科学研究科, 助教 (30601588)
Keywords認知症 / 早期診断 / 脳波 / 画像診断 / fMRI / 視覚 / 聴覚 / 触覚
Research Abstract

平成23年度も代表者と分担者が.医学出身と工学出身の海外研究者と院生を含む国内研究者の協力を得て,欧米やアジアへの現地訪問や通信調査などの手段を用いて,(1)海外での認知症調査研究,(2)認知症診断技術の国際基準の提案,および(3)認知症社会対策の提言を目指して調査研究を実施した.
共同研究者を通じて海外の認知症に関する研究者と連絡を取り,認知症の早期診断と客観的な判断基準の制定が重要であるという共通認識のもとに,認知症に関する認知実験,画像診断,生体信号測定などの実験結果を集め,検討を行っている.特に触角による実験では,健康高齢者と認知症患者の間に認知機能に差が見られる結果が得られており,より多くのデータを集めるために,国際的に大規模な実験を行う必要があることがわかってきた.他の実験結果や発表論文なども調査し,認知症早期診断に有効な手法について検討を進めている.同時に研究分担者間でも画像診断に関する測定結果を持ち寄り,認知機能に関する検討を行っている.また認知症患者の社会生活における問題点についても調査しており,運転免許などに関する世界各国での対策状況などについて調査を進めている.
これらの結果をまとめ,問題点と検討事項を常に点検しながら,認知症診断国際基準の提案と認知症社会対策の提言,および認知症診断に関する早期診断技術,波形診断技術,画像診断技術へのフィードバックを目指して,引き続き来年度も実施する.

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

共同研究者を通じて海外の研究状況を調査しており,海外で臨床実験も実施して認知症の早期診断に向けた海外調査研究が予定通りに進んでいるといえる.

Strategy for Future Research Activity

これまでに得られた認知症の早期診断基準の有効性を確かめるためには,多くの被験者のデータを得る必要がある.また生活習慣の違いを考えると,国際的な大規模な調査研究と臨床実験が必要になると考えている.

  • Research Products

    (50 results)

All 2012 2011

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (42 results) Book (1 results)

  • [Journal Article] Programmable Tactile Pattern Presentations Operational under MRI to Investigate Neural Mechanisms of Tactile Shape Discrimination2011

    • Author(s)
      Jiajia Yang, Jinglong Wuand Jiping He
    • Journal Title

      Journal of Neuroscience Methods

      Volume: Vol.201 Pages: 17-26

    • Peer Reviewed
  • [Journal Article] The Contribution of Pinna Cues to Human Sound Discriminate Ability of Vertical Angle in Sagittal Planes2011

    • Author(s)
      Tianyi Yan and Jinglong Wu
    • Journal Title

      Information

      Volume: Vol.14, No.10 Pages: 3555-3566

    • Peer Reviewed
  • [Journal Article] Neural Substrates of Priming Effect for Japanese Word and Nonword when Compared to Figure Form2011

    • Author(s)
      Chunlin Li, Xiujun Li, Hiroshi Kusahara and Jinglong Wu
    • Journal Title

      Information

      Volume: Vol.14, No.8 Pages: 2911-2924

    • Peer Reviewed
  • [Journal Article] Spatial Attention Improve Performance of Pointing Movement2011

    • Author(s)
      Jiajia Yang, Motohiko Omodani and Jinglong Wu
    • Journal Title

      Information

      Volume: Vol.14, No.6 Pages: 2009-2017

    • Peer Reviewed
  • [Journal Article] Development of A Wide-view Visual Presentation System for Visual Retinotopic Mapping during functional MRI2011

    • Author(s)
      Tianyi Yan, Fengzhe Jin, Jiping He and Jinglong Wu
    • Journal Title

      Journal of Magnetic Resonance Imaging

      Volume: Vol.33(2) Pages: 441-447

    • Peer Reviewed
  • [Journal Article] 緊急時における車制動行為のペダル配置と加齢効果の検討2011

    • Author(s)
      呉景龍, 古谷慎平, 楊家家, 高橋智
    • Journal Title

      日本機械学会論文集C編

      Volume: Vol.77, No.777 Pages: 2062-2070

    • Peer Reviewed
  • [Journal Article] 4自由度長さ提示装置の製作と指先の長さ知覚実験2011

    • Author(s)
      呉景龍, 王海波, 北山直嗣, 高橋智
    • Journal Title

      日本機械学会論文集C編

      Volume: Vol.77, No.778 Pages: 2336-2342

    • Peer Reviewed
  • [Presentation] 顔識別の脳機能に関するfMRI実験の設計と実施2012

    • Author(s)
      北村直樹, 王彬, 高橋智, 呉景龍
    • Organizer
      日本機械学会中国四国支部第50期総会・講演会
    • Place of Presentation
      広島
    • Year and Date
      2012-03-08
  • [Presentation] Tactile and Audiovisual Approach for Early Detection of Alzheimer's Disease2012

    • Author(s)
      Jinglong Wu
    • Organizer
      The 2012 International Symposium on Early Detection and Rehabilitation Technology of Dementia (DRD2012)
    • Place of Presentation
      岡山(招待講演)
    • Year and Date
      2012-03-01
  • [Presentation] Differences of Brain Activation Among Normal and PD Patients During Audiovisual Exogenous Attention : An fMRI Study2012

    • Author(s)
      Naoya Nakamura, Jiajia Yang, Chunlin Li, Jinglong Wu
    • Organizer
      The 2012 International Symposium on Early Detection and Rehabilitation Technology of Dementia (DRD2012)
    • Place of Presentation
      岡山
    • Year and Date
      2012-03-01
  • [Presentation] The Normal Aging of Resting-state Networks : an fMRI Study2012

    • Author(s)
      Fuminori Yoshi-tomi, Chunlin Li, Jinglong Wu
    • Organizer
      The 2012 International Symposium on Early Detection and Rehabilitation Technology of Dementia (DRD2012)
    • Place of Presentation
      岡山
    • Year and Date
      2012-03-01
  • [Presentation] An fMRI study on aging effect in the spatial attention2012

    • Author(s)
      Yuya Kawata, Chunlin Li, Jinglong Wu
    • Organizer
      The 2012 International Symposium on Early Detection and Rehabilitation Technology of Dementia (DRD2012)
    • Place of Presentation
      岡山
    • Year and Date
      2012-03-01
  • [Presentation] Development of a tactile angle stimuli presentation device for early diagno-sis of Dementia2012

    • Author(s)
      Mohd Usairy Syafiq, Jiajia Yang, Jinglong Wu
    • Organizer
      The 2012 International Symposium on Early Detection and Rehabilitation Technology of Dementia (DRD2012)
    • Place of Presentation
      岡山
    • Year and Date
      2012-03-01
  • [Presentation] Neural Substrates for Phonological Processing of Japanese Kanji and Chi-nese Characters in Bilingual Japanese2012

    • Author(s)
      QiGeQi, Jinglong Wu
    • Organizer
      The 2012 International Symposium on Early Detection and Rehabilitation Technology of Dementia (DRD2012)
    • Place of Presentation
      岡山
    • Year and Date
      2012-03-01
  • [Presentation] Differential activity of semantic and font size processing of Japanese word by Chinese-Japanese bilingual2012

    • Author(s)
      Zhenglong Lin, Xiujun Li, Jinglong Wu
    • Organizer
      The 2012 International Symposium on Early Detection and Rehabilitation Technology of Dementia (DRD2012)
    • Place of Presentation
      岡山
    • Year and Date
      2012-03-01
  • [Presentation] Multisensory integration elicited by audiovisual spatial congruent stimulii2012

    • Author(s)
      Takahiro Kimura, Weiping Yang, Jinglong Wu
    • Organizer
      The 2012 International Symposium on Early Detection and Rehabilitation Technology of Dementia (DRD2012)
    • Place of Presentation
      岡山
    • Year and Date
      2012-03-01
  • [Presentation] Effects of the Spatial Location of Auditory Stimuli on Visual Attention : An Event-Related Potential Study2012

    • Author(s)
      Tatsuya Ochi, Jingjing Yang, Jinglong Wu
    • Organizer
      The 2012 International Symposium on Early Detection and Rehabilitation Technology of Dementia (DRD2012)
    • Place of Presentation
      岡山
    • Year and Date
      2012-03-01
  • [Presentation] The aging effect of masking noise on horizontal sound localization ability2012

    • Author(s)
      Kensuke Kawamura, Jinglong Wu
    • Organizer
      The 2012 International Symposium on Early Detection and Rehabilitation Technology of Dementia (DRD2012)
    • Place of Presentation
      岡山
    • Year and Date
      2012-03-01
  • [Presentation] Measurement of brain activation associated with tactile memory by tactile angles matching task2012

    • Author(s)
      Suguru Yokotani, Jiajia Yang, Jinglong Wu
    • Organizer
      The 2012 International Symposium on Early Detection and Rehabilitation Technology of Dementia (DRD2012)
    • Place of Presentation
      岡山
    • Year and Date
      2012-03-01
  • [Presentation] Development and evaluation of a haptic length presentation device for fMRI study2012

    • Author(s)
      Munemitsu Goh, Jiajia Yang, Jinglong Wu
    • Organizer
      The 2012 International Symposium on Early Detection and Rehabilitation Technology of Dementia (DRD2012)
    • Place of Presentation
      岡山
    • Year and Date
      2012-03-01
  • [Presentation] Brain activations related to tactile speed discrimination : an fMRI study2012

    • Author(s)
      Yuta Araki, Jiajia Yang, Ryo Kitada, Norihiro Sadato, Jinglong Wu
    • Organizer
      The 2012 International Symposium on Early Detection and Rehabilitation Technology of Dementia (DRD2012)
    • Place of Presentation
      岡山
    • Year and Date
      2012-03-01
  • [Presentation] The Influence of Eccentricity on Neural Activation in Ventral Visual Cortex2012

    • Author(s)
      Wang Bin, Yu Hikino, Satoshi Takahashi, Jinglong Wu
    • Organizer
      The 2012 International Symposium on Early Detection and Rehabilitation Technology of Dementia (DRD2012)
    • Place of Presentation
      岡山
    • Year and Date
      2012-03-01
  • [Presentation] Different brain activation of semantic processing between Chinese-Japanese bilinguals and Japanese native speakers2012

    • Author(s)
      Ryoji Koyama, Xiujun Li, Jinglong Wu
    • Organizer
      The 2012 International Symposium on Early Detection and Rehabilitation Technology of Dementia (DRD2012)
    • Place of Presentation
      岡山
    • Year and Date
      2012-03-01
  • [Presentation] 触覚角度弁別を用いたアルツハイマー型認知症スクリーニング検査方法の開発2011

    • Author(s)
      楊家家,太田康之,阿部康二,呉景龍
    • Organizer
      第30回日本認知症学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      20111111-13
  • [Presentation] 視覚及び聴覚能動空間注意における共通の前頭頭頂連合活動:fMRI研究2011

    • Author(s)
      李春林, 呉景龍
    • Organizer
      第13回ヒト脳機能マッピング学会
    • Place of Presentation
      京都
    • Year and Date
      20110901-20110902
  • [Presentation] 事象関連電位(ERP)を用いた片耳と両耳の聴覚刺激が視覚注意に及ぼす影響に関する研究2011

    • Author(s)
      高玉林, 楊菁菁, 峠哲男, 呉景龍
    • Organizer
      第13回ヒト脳機能マッピング学会
    • Place of Presentation
      京都
    • Year and Date
      20110901-20110902
  • [Presentation] 二重触覚による角度弁別の脳内処理領域の同定2011

    • Author(s)
      楊家家, 呉景龍
    • Organizer
      第13回ヒト脳機能マッピング学会
    • Place of Presentation
      京都
    • Year and Date
      20110901-20110902
  • [Presentation] 中国語聴覚言語処理における非文盲者の右脳優位性に関するfMRI研究2011

    • Author(s)
      李修軍, 郭啓勇, 呉景龍
    • Organizer
      第13回ヒト脳機能マッピング学会
    • Place of Presentation
      京都
    • Year and Date
      20110901-20110902
  • [Presentation] Ventral Occipito-Temporal Region Doesn't Show Lateralized Activity for Word Matching2011

    • Author(s)
      其格其, 李修軍, 閻天翼, 呉景龍, 郭啓勇
    • Organizer
      第13回ヒト脳機能マッピング学会
    • Place of Presentation
      京都
    • Year and Date
      20110901-20110902
  • [Presentation] 聴覚刺激の提示位置と視覚注意との関連性に関する事象関連電位(ERP)の検討2011

    • Author(s)
      高玉林, 李奇, 楊菁菁, 呉景龍
    • Organizer
      第20回計測自動制御学会中国支部学術講演
    • Place of Presentation
      岡山
    • Year and Date
      2011-11-26
  • [Presentation] 中国語の発音弁別処理における文盲者の脳内活動の検討2011

    • Author(s)
      小山竜史, 李修軍, 呉景龍, 高橋智
    • Organizer
      第20回計測自動制御学会中国支部学術講演
    • Place of Presentation
      岡山
    • Year and Date
      2011-11-26
  • [Presentation] fMRIを用いた視触覚空間能動分割注意についての検討2011

    • Author(s)
      呉ケイ, 李春林, 呉景龍
    • Organizer
      第20回計測自動制御学会中国支部学術講演
    • Place of Presentation
      岡山
    • Year and Date
      2011-11-26
  • [Presentation] 視聴覚統合に及ぼす聴覚刺激の呈示位置の影響に関する検討2011

    • Author(s)
      越智達也, 呉景龍, 高橋智, 李奇
    • Organizer
      第20回計測自動制御学会中国支部学術講演
    • Place of Presentation
      岡山
    • Year and Date
      2011-11-26
  • [Presentation] Ipsilateral visual and auditory spatial information interaction mechanisms in selective attention conditions : Behavioral and ERP study2011

    • Author(s)
      Yulin Gao, Qi Li, Jingjing Yang, Jinglong Wu
    • Organizer
      2011 IEEE International Conference on Mechatronics and Automation (ICMA2011)
    • Place of Presentation
      北京,中国
    • Year and Date
      2011-08-10
  • [Presentation] Early Detection of Patients with Mild Cognitive Impairment and Alzheimer's Disease using a Novel Tactile Approach2011

    • Author(s)
      Jiajia Yang, Yinghua Yu, Yong Shen, Yasuyuki Ohta, Koji Abe, Jinglong Wu
    • Organizer
      Alzheimer's Association International Conference on Alzheimer's Disease (AAICAD)
    • Place of Presentation
      Paris, France
    • Year and Date
      2011-07-17
  • [Presentation] Audiovisual Integration of Normal aged Controls Compared to Patients with Mild Cognitive Impairment and Alzheimer's Disease2011

    • Author(s)
      Jinglong Wu, Jiajia Yang, Naoya Nakamura, Qi Li, Yong Shen, Yasuyuki Ohta, Koji Abe
    • Organizer
      Alzheimer's Association International Conference on Alzheimer's Disease (AAICAD)
    • Place of Presentation
      Paris, France
    • Year and Date
      2011-07-17
  • [Presentation] Distinguish The Visual Top-Down Spatial Attentional Neural Network Between Normal And Dementia2011

    • Author(s)
      Chunlin Li, Yasuyuki Ohta, Koji Abe, Kewei Chen, Yong Shen, Jinglong Wu
    • Organizer
      Alzheimer's Association International Conference on Alzheimer's Disease (AAICAD)
    • Place of Presentation
      Paris, France
    • Year and Date
      2011-07-17
  • [Presentation] 触覚による速度弁別実験装置の設計と開発について2011

    • Author(s)
      荒木雄太, 楊家家, 高橋智, 呉景龍
    • Organizer
      日本機械学会ロボティクス・メカトロニクス講演会2011
    • Place of Presentation
      岡山
    • Year and Date
      2011-05-28
  • [Presentation] 視覚情報制御できるポインティング行動実験装置の開発と評価2011

    • Author(s)
      稲井佳暢, 楊家家, 高橋智, 呉景龍
    • Organizer
      日本機械学会ロボティクス・メカトロニクス講演会2011
    • Place of Presentation
      岡山
    • Year and Date
      2011-05-28
  • [Presentation] Developing a Logistic Regression Model with Cross-Correlation for Motor Imagery Signal Recognition2011

    • Author(s)
      Siuly, Yan Li, Jinglong Wu, Jingjing Yang
    • Organizer
      2011 IEEE/ICME International Conference on Complex Medical Engineering (CME2011)
    • Place of Presentation
      ハルビン・中国
    • Year and Date
      2011-05-24
  • [Presentation] An International Investigation of Social Circumstances and Driver Licenses for Elder Persons2011

    • Author(s)
      Satoshi Takahashi, Jinglong Wu
    • Organizer
      2011 IEEE/ICME International Conference on Complex Medical Engineering (CME2011)
    • Place of Presentation
      ハルビン・中国
    • Year and Date
      2011-05-24
  • [Presentation] Human Characteristics on Tactile Angle Discrimination by Object Movement Condition2011

    • Author(s)
      Jiajia Yang, Jinglong Wu
    • Organizer
      2011 IEEE/ICME International Conference on Complex Medical Engineering (CME2011)
    • Place of Presentation
      ハルビン・中国
    • Year and Date
      2011-05-24
  • [Presentation] Development and Evaluation of a MRI-Compatible Tactile Orientation Stimulator2011

    • Author(s)
      Yinghua Yu, Jiajia Yang, Jinglong Wu, Qiyong Guo
    • Organizer
      2011 IEEE/ICME International Conference on Complex Medical Engineering (CME2011)
    • Place of Presentation
      ハルビン・中国
    • Year and Date
      2011-05-24
  • [Presentation] Differential activity of phonological and orthographic processing of Japanese word : an fMRI study2011

    • Author(s)
      Xiujun Li, Zhenglong Lin, Ryoji Koyama, Jinglong Wu, Hongzan Sun, Qiyong Guo
    • Organizer
      2011 IEEE/ICME International Conference on Complex Medical Engineering (CME2011)
    • Place of Presentation
      ハルビン・中国
    • Year and Date
      2011-05-24
  • [Presentation] Effect of Visual Spatial Information on Tactile Spatial Attention : An fMRI Study2011

    • Author(s)
      Qiong Wu, Chunlin Li, Qiyong Guo, Jinglong Wu
    • Organizer
      2011 IEEE/ICME International Conference on Complex Medical Engineering (CME2011)
    • Place of Presentation
      ハルビン・中国
    • Year and Date
      2011-05-24
  • [Presentation] Retinotopy Mapping for Face Stimuli and Attention in the Fusiform Face Area2011

    • Author(s)
      Bing Wang, Tianyi Yan, Bing Yu, Qiyong Guo, Jinglong Wu
    • Organizer
      2011 IEEE/ICME International Conference on Complex Medical Engineering (CME2011)
    • Place of Presentation
      ハルビン・中国
    • Year and Date
      2011-05-24
  • [Presentation] Attention Influence Response in The Human Visual Area V1 for Ebbinghaus Illusion2011

    • Author(s)
      Tianyi Yan, Bin Wang, Yuji Yamasita, Bing Yu, Qiyong Guo, Jinglong Wu
    • Organizer
      2011 IEEE/ICME International Conference on Complex Medical Engineering (CME2011)
    • Place of Presentation
      ハルビン・中国
    • Year and Date
      2011-05-24
  • [Presentation] Audiovisual integration elicited by stimuli peripherally in divided attention task : An Event-Related Potential Study2011

    • Author(s)
      Weiping Yang, Jingjing Yang, Takahiro Kimura, Jinglong Wu
    • Organizer
      2011 IEEE/ICME International Conference on Complex Medical Engineering (CME2011)
    • Place of Presentation
      ハルビン・中国
    • Year and Date
      2011-05-23
  • [Presentation] Task-irrelevant Auditory Stimuli Affect Audiovisual Integration in a Visual Attention Task : Evidence from Event-related Potentials2011

    • Author(s)
      Jingjing Yang, Yulin Gao, Qi Li, Jinglong Wu
    • Organizer
      2011 IEEE/ICME International Conference on Complex Medical Engineering (CME2011)
    • Place of Presentation
      ハルビン・中国
    • Year and Date
      2011-05-23
  • [Book] Early Detection and Rehabilitation Technologies for Dementia : Neviroscience and Biomedical Applications2011

    • Author(s)
      Jinglong Wu(監修)
    • Total Pages
      442
    • Publisher
      IGI Global

URL: 

Published: 2013-06-26  

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