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2011 Fiscal Year Final Research Report

Investigation of benthonic marine organisms in Indonesia searching for new medicinal seeds.

Research Project

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Project/Area Number 21406002
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Living organism molecular science
Research InstitutionOsaka University

Principal Investigator

KOBAYASHI Motomasa  大阪大学, 大学院・薬学研究科, 教授 (40116033)

Co-Investigator(Renkei-kenkyūsha) ARAI Masayoshi  大阪大学, 大学院・薬学研究科, 准教授 (80311231)
TANAKA Junichi  琉球大学, 理学部, 教授 (20163529)
Project Period (FY) 2009 – 2011
Keywords海洋生物 / 海綿 / 海洋微生物 / インドネシア / 医薬シーズ / 活性物質
Research Abstract

To develop the new medicinal resources, we collected 279 samples of benthonic marine organisms in the coral reef of the west side of Timor Island(Kupang area), the around of Biak Island and the Flores Island(Maumere area) at Indonesia, and prepared the specimen and the extracts from the collected samples. In addition, we prepared the list of samples, which contained information of the distribution, environments and morphological characteristics based on the pictures of marine organisms under the water, results of the bioassay and the active constituents in the samples. We also have prepared the list of 140 kinds of fungi isolated from sea sands and marine organisms.

  • Research Products

    (27 results)

All 2012 2011 2010 2009 Other

All Journal Article (10 results) (of which Peer Reviewed: 9 results) Presentation (16 results) Remarks (1 results)

  • [Journal Article] Action-mechanism of trichoderin A, an anti-dormant mycobacterial aminolipopeptide from marine sponge-derived Trichoderma sp2011

    • Author(s)
      Pruksakorn P., Arai M., Liu L., Moodley P., Jacobs Jr. W. R., Kobayashi M.
    • Journal Title

      Biol. Pharm. Bull

      Volume: 34(8) Pages: 1287-1290

    • Peer Reviewed
  • [Journal Article] DedA protein relates to action-mechanism of halicyclamine A, a marine spongean macrocyclic alkaloid, as an anti-dormant mycobacterial substance2011

    • Author(s)
      Arai M., Liu L., Fujimoto T., Setiawan A., Kobayashi M.
    • Journal Title

      Marine Drugs

      Volume: 9(6) Pages: 984-993

    • Peer Reviewed
  • [Journal Article] Inhibitory effect of cyclic trihydroxamate siderophore, desferrioxamine E, on the biofilm formation of Mycobacterium species2011

    • Author(s)
      Ishida S., Arai M., Nikawa H., Kobayashi M.
    • Journal Title

      Biol. Pharm. Bull

      Volume: 34(6) Pages: 917-920

    • Peer Reviewed
  • [Journal Article] Hypoxia-selective growth inhibition of cancer cells by furospinosulin-1, a furanosesterterpene isolated from an Indonesian marine sponge2010

    • Author(s)
      Arai M., Kawachi T., Setiawan A., Kobayashi M.
    • Journal Title

      ChemMedChem

      Volume: 5(11) Pages: 1919-1926

    • Peer Reviewed
  • [Journal Article] Pruksakorn P., Arai M., Kotoku N., Vilcheze C., Baughn A. D., Moodley P., Jacobs Jr. W. R., Kobayashi M.2010

    • Author(s)
      Pruksakorn P., Arai M., Kotoku N., Vilcheze C., Baughn A. D., Moodley P., Jacobs Jr. W. R., Kobayashi M.
    • Journal Title

      Bioorg. Med. Chem. Lett

      Volume: 20(12) Pages: 3658-3663

    • Peer Reviewed
  • [Journal Article] 海洋生物からの医薬シーズ探索2010

    • Author(s)
      井雅吉、小林資正
    • Journal Title

      有機合成化学協会誌

      Volume: 68巻 Pages: 470-479

    • Peer Reviewed
  • [Journal Article] Pyripyropenes, fungal sesquiterpenes conjugated with.-pyrone and pyridine moieties, exhibits anti-angiogenic activity against human umbilical vein endothelial cells2009

    • Author(s)
      Hayashi A., Arai M., Fujita M., Kobayashi M.
    • Journal Title

      Biol. Pharm. Bull

      Volume: 32(7) Pages: 1261-1265

    • Peer Reviewed
  • [Journal Article] Dysideamine, a new sesquiterpene aminoquinone, protects hippocampal neuronal cells against iodoacetic acid-induced cell death2009

    • Author(s)
      Suna H., Arai M., Tsubotani Y., Hayashi A., Setiawan A., Kobayashi M.
    • Journal Title

      Bioorg. Med. Chem

      Volume: 17(11) Pages: 3968-3972

    • Peer Reviewed
  • [Journal Article] Haliclonacyclamines, tetracyclic alkylpiperidine alkaloids, as anti-dormant mycobacterial substances from a marine sponge of Haliclona sp2009

    • Author(s)
      Arai M., Ishida S., Setiawan A., Kobayashi M.
    • Journal Title

      Chem. Pharm. Bull

      Volume: 57(10) Pages: 1136-1138

    • Peer Reviewed
  • [Journal Article] 海洋天然物のケミカルバイオロジー2009

    • Author(s)
      荒井雅吉、小林資正
    • Journal Title

      化学と生物47巻化学と生物

      Volume: 47巻 Pages: 275-282

  • [Presentation] 海綿由来の新しい医薬シーズの探索2012

    • Author(s)
      小林資正
    • Organizer
      中西シンポジウム2012
    • Place of Presentation
      東京
    • Year and Date
      2012-03-25
  • [Presentation] Medicinal Seeds for Cancer Chemotherapy from Marine Organisms2011

    • Author(s)
      Motomasa Kobayashi
    • Organizer
      7th U. S.-Japan Seminar on Marine Natural Products
    • Place of Presentation
      沖縄
    • Year and Date
      2011-12-12
  • [Presentation] 腫瘍微小環境で作用する新規抗がん剤の探索2011

    • Author(s)
      荒井雅吉、河内崇志、古徳直之、小林資正
    • Organizer
      第4回食品薬学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-10-29
  • [Presentation] がん転移抑制を指向した細胞接着阻害天然物の探索2011

    • Author(s)
      戸田和成、田村理、荒井雅吉、小林資正
    • Organizer
      第61回日本薬学会近畿支部総会・大会
    • Place of Presentation
      兵庫
    • Year and Date
      2011-10-22
  • [Presentation] インドネシア産海綿由来の新規環状デプシペプチドneamphamide Bの抗潜在性結核活性2011

    • Author(s)
      山野喜、荒井雅吉、小林資正
    • Organizer
      日本生薬学会第58回年会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-24
  • [Presentation] 海綿由来セスタテルペンheteroneminのbiofilm形成阻害活性2011

    • Author(s)
      韓智秀、荒井雅吉、石田俊介、新川大貴、小林資正
    • Organizer
      日本生薬学会第58回年会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-24
  • [Presentation] Search for New Medicinal Seeds for Cancer Chemotherapy from Marine Organisms2011

    • Author(s)
      Motomasa Kobayashi
    • Organizer
      Tetrahedron Prize for Creativity in Organic Chemistry Symposium
    • Place of Presentation
      Denver(米国)
    • Year and Date
      2011-08-29
  • [Presentation] インドネシア産海綿由来の新規環状ペプチドaxinellin Dのがん細胞浸潤阻害作用2010

    • Author(s)
      山野喜、荒井雅吉、藤田真由美、小林資正
    • Organizer
      日本生薬学会第57回年会
    • Place of Presentation
      徳島
    • Year and Date
      2010-09-25
  • [Presentation] 海洋由来放線菌が産生するdesferrioxamine Eのbiofilm形成阻害活性2010

    • Author(s)
      石田俊介、荒井雅吉、小林資正
    • Organizer
      日本生薬学会第57回年会
    • Place of Presentation
      徳島
    • Year and Date
      2010-09-25
  • [Presentation] 海洋天然物由来の医薬シーズの探索2010

    • Author(s)
      小林資正
    • Organizer
      第27回和漢医薬学会学術大会
    • Place of Presentation
      京都
    • Year and Date
      2010-08-28
  • [Presentation] 海綿由来の大環状アルカロイドhalicyclamine類の潜在性結核菌に対する抗菌活性とその作用メカニズムの解析2009

    • Author(s)
      荒井雅吉、劉柳、石田俊介、惣坊真理、小林資正
    • Organizer
      第28回メディシナルケミストリーシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-11-25
  • [Presentation] 海洋由来真菌が産生する新規アミノリポペプチドtrichoderin類の抗結核活性とその作用メカニズム2009

    • Author(s)
      荒井雅吉、Patamaporn Pruksakorn、古徳直之、小林資正
    • Organizer
      日本生薬学会第56回年会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-04
  • [Presentation] 海綿由来の大環状アルカロイドhaliclonacyclamine類の潜在性結核菌に対する抗菌活性とその作用メカニズム解析2009

    • Author(s)
      荒井雅吉、劉柳、石田俊介、藤本貴男、惣坊真理、小林資正
    • Organizer
      日本生薬学会第56回年会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-04
  • [Presentation] 海洋由来真菌が産生するセスキテルペンpyripyropene類のHUVECs選択的増殖抑制効果2009

    • Author(s)
      林亜紗実、荒井雅吉、藤田真由美、小林資正
    • Organizer
      日本生薬学会第56回年会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-03
  • [Presentation] Hypoxia-selective growth inhibitor, furospinosulin-1, from Indonesian marine sponge2009

    • Author(s)
      Masayoshi Arai, Takashi Kawachi, Naoyuki Kotoku, Yuji Sumii, Motomasa Kobayashi
    • Organizer
      The 25th Naito Conference on Chemical Biology
    • Place of Presentation
      北海道
    • Year and Date
      2009-09-09
  • [Presentation] インドネシア産海綿由来furospinosulin-1の低酸素環境選択的細胞毒性2009

    • Author(s)
      荒井雅吉、河内崇志、小林資正
    • Organizer
      第13回日本がん分子標的治療学会
    • Place of Presentation
      徳島
    • Year and Date
      2009-06-25
  • [Remarks]

    • URL

      http://www.phs.osaka-u.ac.jp/homepage/b012/

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Published: 2013-07-31  

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