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2011 Fiscal Year Final Research Report

Search and collection of pathogenic fungi and actinomycetes in areas with high incidents of AIDS patients.

Research Project

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Project/Area Number 21406003
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Resource conservation science
Research InstitutionChiba University

Principal Investigator

GONOI Tohru  千葉大学, 真菌医学研究センター, 教授 (30134365)

Co-Investigator(Kenkyū-buntansha) YAGUCHI Takashi  千葉大学, 真菌医学研究センター, 准教授 (60361440)
MATSUO Takatoshi  千葉大学, 真菌医学研究センター, 研究機関研究員 (00500737)
Project Period (FY) 2009 – 2011
Keywords病原真菌 / 病原放線菌 / ノカルジア / カンジダ / 真菌症 / ノカルジア症
Research Abstract

AIDS, by debilitating the immune system, causes serious illness by a secondary infection with bacteria, fungi and other pathogens, and the 2nd infection often bring patient death. We collected pathogenic actinomycetes and fungi from AIDS patients in collaboration with researchers in Brazil, Thailand, South Africa and Indonesia. We are constructing database of the strains collected with patient-information, minimal inhibitory concentrations of drugs, photos of microbes, gene sequences, and others for contribution and utilization for medical and scientific purposes.

  • Research Products

    (60 results)

All 2011 2010 2009 Other

All Journal Article (51 results) (of which Peer Reviewed: 37 results) Presentation (3 results) Book (1 results) Remarks (2 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Journal Article] Streptomyces coacervatus sp. nov. isolated from the intestinal tract of Armadillidium vulgare2011

    • Author(s)
      Shibazaki A, Omoto Y, Kudo T, Yaguchi T, Saito A, Ando A, Mikami Y, Gonoi T
    • Journal Title

      International Journal of Systemic and Evolutional Microbiology

      Volume: 61 Pages: 1073-1077

    • Peer Reviewed
  • [Journal Article] prenylated acylphloroglucinols from Hypericum yojiroanum2011

    • Author(s)
      Tanaka N, Mamemura T, Shibazaki A, Gonoi T, Kobayashi J.
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 21 Pages: 5393-7

    • Peer Reviewed
  • [Journal Article] Nakijinamines C-E, new heteroaromatic alkaloids from the sponge Suberites species2011

    • Author(s)
      Takahashi Y, Kubota T, Shibazaki A, Gonoi T, Fromont J, Kobayashi J
    • Journal Title

      Org Lett

      Volume: 13(12) Pages: 3016-9

    • Peer Reviewed
  • [Journal Article] Pulmonary nocardiosis caused by Nocardia exalbida complicating Pneumocystis pneumonia in an HIV-infected patient2011

    • Author(s)
      Imai K, Koibuchi T, Kikuchi T, Koga M, Nakamura H, Miura T, Gonoi T, Yazawa K, Iwamoto A, Fujii T.
    • Journal Title

      J Infect Chemother

      Volume: 17(4) Pages: 547-51

    • Peer Reviewed
  • [Journal Article] Profiling the cell surface glycome of live fungi using lectin microarray2011

    • Author(s)
      Shibazaki A, Tateno H, Ando A, Hirabayashi J, Gonoi T
    • Journal Title

      Carbohydrate Chemistry

      Volume: 30 Pages: 147-164

    • Peer Reviewed
  • [Journal Article] Refeeding with a high-protein diet after a 48 h fast causes acute hepatocellular injury in mice2011

    • Author(s)
      Oarada M, Tsuzuki T, Nikawa T, Kohno S, Katsuya Hirasaka K, Gonoi T
    • Journal Title

      British Journal of Nutrition

    • Peer Reviewed
  • [Journal Article] Microsatellite-based genotyping of Candida albicans isolated from patients with superficial candidiasis2011

    • Author(s)
      Shimizu K, Hattori H, Adachi H, Oshima R, Horii T, Tanaka R, Yaguchi T, Tomita Y, Akiyama M, Kawamoto F, Kanbe T
    • Journal Title

      Med Mycol J

      Volume: 52 Pages: 129-138

    • Peer Reviewed
  • [Journal Article] Genotypes of Candia albicans involved in development of candidiasis and their distribution in oral cavity of non-candidiasis individuals.2011

    • Author(s)
      Takagi Y, Hattori H, Adachi H, Takakura S, Horii T, Chindamporn A, Kitai H, Tanaka R, Yaguchi T, Fukano H, Kawamoto F, Shimozato K, Kanbe T
    • Journal Title

      Med Mycol J

      Volume: 52 Pages: 315-324

    • Peer Reviewed
  • [Journal Article] A new antifungal yellow pigment from Aspergillus nishimurae2011

    • Author(s)
      Hosoe T, Mori N, Kamano K, Itabashi T, Yaguchi T, Kawai K
    • Journal Title

      J Antibiot

      Volume: 64 Pages: 211-212

    • Peer Reviewed
  • [Journal Article] Lymphocutaneous type of nocardiosis caused by Nocardia vinacea in a patient with polymyositis2011

    • Author(s)
      Iwasawa MT, Togawa Y, Kamada N, Kambe N, Matsue H, Yazawa K, Yaguchi T, Mikami Y
    • Journal Title

      Mycopathologia

      Volume: 172 Pages: 47-53

    • Peer Reviewed
  • [Journal Article] New type indole diterpene, eujindoles, from Eupenicillium javanicum.2011

    • Author(s)
      Nakadate S, Nozawa K, Horie H, Fujii Y, Yaguchi T
    • Journal Title

      Heterocycles

      Volume: 82 Pages: 351-356

    • Peer Reviewed
  • [Journal Article] Two new eujindoles from Eupenicillium javanicum2011

    • Author(s)
      Nakadate S, Nozawa K, Yaguchi T
    • Journal Title

      Heterocycles

      Volume: 83 Pages: 1867-1871

    • Peer Reviewed
  • [Journal Article] An antifungal substance isolated from Eupenicillium javanicum IFM 582142011

    • Author(s)
      Nakadate S, Nozawa K, Yaguchi T
    • Journal Title

      Mycotoxins

      Volume: 61 Pages: 41-46

    • Peer Reviewed
  • [Journal Article] Mikami Y (2010) Phylogenetic studies of genus Nocardia species based on gyrB gene analyses2010

    • Author(s)
      Takeda K, Kang Y, Yazawa K, Gonoi T
    • Journal Title

      J Med Microbiol

      Volume: 59 Pages: 165-171

    • Peer Reviewed
  • [Journal Article] Homozygous Triplicate Mutations in Three 16S rRNA Genes : Responsible for High-level Aminoglycoside Resistance in Nocardia farcinica Clinically Isolated in the Canada-Wide Bovine Mastitis Epizootic2010

    • Author(s)
      Kogure T, Shimada R, Ishikawa J, Yazawa K, Brown JM, Mikami Y, Gonoi T
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 54(6) Pages: 2385-90

    • Peer Reviewed
  • [Journal Article] Effects of a high protein diet on host resistance to Paracoccidioides brasiliensis in mice2010

    • Author(s)
      Oarada M, Igarashi M, Tsuzuki T, Kamei K, Hirasaka K, Nikawa T, Miyazawa T, Nakagawa K, Gonoi T
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 74 Pages: 620-626

    • Peer Reviewed
  • [Journal Article] Development of rapid and specific molecular discrimination methods for pathogenic Emericella species2010

    • Author(s)
      Matsuzawa T, Tanaka R, Horie Y, Gonoi T, Yaguchi T
    • Journal Title

      Jpn J Med Mycol

      Volume: 51 Pages: 109-116

    • Peer Reviewed
  • [Journal Article] Kobayashi J. Ceratinadins A-C, new bromotyrosine alkaloids from an Okinawan marine sponge Pseudoceratina sp2010

    • Author(s)
      Kon Y, Kubota T, Shibazaki A, Gonoi T
    • Journal Title

      Bioorganic and Medicinal Chemistry Letters

      Volume: 20 Pages: 4569-4572

    • Peer Reviewed
  • [Journal Article] Petiolins J-M, prenylated acylphloroglucinols from Hypericum pseudopetiolatum var. kiusianum2010

    • Author(s)
      Tanaka N, Otani M, Kashiwada Y, Takaishi Y, Shibazaki A, Gonoi T, Shiro M, Kobayashi J.
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 20(15) Pages: 4451-5

  • [Journal Article] Two new species of Neosartorya from soil in Xinjiang2010

    • Author(s)
      Yaguchi T, Matsuzawa T, Tanaka R, Abliz P, Hui Y, Horie Y
    • Journal Title

      China. Mycoscience

      Volume: 51 Pages: 253-262

    • Peer Reviewed
  • [Journal Article] Genotyping of fluconazole-resistant Candida albicans isolated from Uighurian living in Xinjiang (China), using ALTS/RFLP and μ-TGGE method2010

    • Author(s)
      Mijiti J, Pu XM, Erfan A, Yaguchi T, Chibana H, Tanaka R
    • Journal Title

      pn J Med Mycol

      Volume: 51 Pages: 165-168

    • Peer Reviewed
  • [Journal Article] Rapid method for identifying Byssochlamys and Hamigera2010

    • Author(s)
      Nakayama M, Hosoya K, Matsuzawa T, Hiro Y, Sako A, Tokuda H, Yaguchi T
    • Journal Title

      Food Prot

      Volume: 73 Pages: 1486-1492

    • Peer Reviewed
  • [Journal Article] Novoamauromine and ent-cycloechinulin : Two new diketopiperazine derivatives from Aspergillus novofumigatus2010

    • Author(s)
      Ishikawa K, Hosoe T, Itabashi T, Wakana D, Takizawa K, Yaguchi T, Kawai K
    • Journal Title

      Chem Pharm Bull

      Volume: 58 Pages: 717-719

    • Peer Reviewed
  • [Journal Article] A novofumigatamide, new cyclic tripeptide from Aspergillus novofumigatus2010

    • Author(s)
      Ishikawa K, Hosoe T, Itabashi T, Takizawa K, Yaguchi T, Kawai K
    • Journal Title

      Heterocycles

      Volume: 81 Pages: 2143-2148

    • Peer Reviewed
  • [Journal Article] Abliz P, Okada K, Takaki GMC:コーヒーノキ樹上における果実にみられた ochratoxin生産菌とochratoxin Aの自然汚染2010

    • Author(s)
      堀江義一, 矢口貴志
    • Journal Title

      日菌報

      Volume: 51 Pages: 3-14

    • Peer Reviewed
  • [Journal Article] かんきつ加工食品の変敗原因となったカビByssochlamys lagunculariae の同定と耐熱性2010

    • Author(s)
      上田成一, 川良希, 矢口貴志, 宇田川俊一
    • Journal Title

      日菌報

      Volume: 51 Pages: 48-58

    • Peer Reviewed
  • [Journal Article] 真菌の分類と検査2010

    • Author(s)
      矢口貴志
    • Journal Title

      日本食品微生物学会雑誌

      Volume: 27(2) Pages: 47-55

  • [Journal Article] PCRによる食品有害カビの分類と同定2010

    • Author(s)
      矢口貴志
    • Journal Title

      日本食品微生物学会雑誌

      Volume: 27(3) Pages: 133-136

  • [Journal Article] Effect of dietary oils on host resistance to fungal infection in psychologically stressed mice2010

    • Author(s)
      Oarada M, Igarashi M, Tsuzuki T, Kurita N, T. Gonoi T, Nikawa T, Hirasaka K, Miyazawa T, Nakagawa K, Kamei K
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 73 Pages: 1994-1998

    • Peer Reviewed
  • [Journal Article] Beneficial effects of a low-protein diet on host resistance to Paracoccidioides brasiliensis in mice2009

    • Author(s)
      Oarada M, Kamei K, Gonoi T, Tsuzuki T, Toyotome T, Hirasaka K, Nikawa T, Sato A, Kurita N.
    • Journal Title

      Nutrition

      Volume: 25 Pages: 954-963

    • Peer Reviewed
  • [Journal Article] Effect of dietary oils on host resistance to fungal infection in psychologically stressed mice. Biosci Biotechnol2009

    • Author(s)
      Oarada M, Igarashi M, Tsuzuki T, Kurita N, T. Gonoi T, Nikawa T, Hirasaka K, Miyazawa T, Nakagawa K, Kamei K
    • Journal Title

      Biochem

      Volume: 73 Pages: 194-1998

    • Peer Reviewed
  • [Journal Article] A new indoloditerpene derivative, penijanthine A, isolated from Penicillium janthinellum2009

    • Author(s)
      Itabashi T, Hosoe T, Wakana D, Fukushima K, Takizawa K, Yaguchi T, Okada K, de Campos Takaki GM, Kawai K
    • Journal Title

      J Nat Med

      Volume: 63 Pages: 96-99

    • Peer Reviewed
  • [Journal Article] Fungal infection of mantis shrimp (Oratosquilla oratoria) caused by two anamorphic fungi found in Japan2009

    • Author(s)
      Duc PM, Hatai K, Kurata O, Tensha K, Uchida Y, Yaguchi T, Udagawa S
    • Journal Title

      Mycopathologia

      Volume: 167 Pages: 229-247

    • Peer Reviewed
  • [Journal Article] The cytotoxic and antfungal activities of two new sesquiterpenes, malfilanol A and B, derived from Malbranchea filamentosa2009

    • Author(s)
      Wakana D, Hosoe T, Wachi H, Itabashi T, Fukushima K, Yaguchi T, Kawai K
    • Journal Title

      J Antibiot

      Volume: 62 Pages: 217-219

    • Peer Reviewed
  • [Journal Article] Characterization of clinical isolates of Gordonia species in Japanese clinical samples during 1998-20082009

    • Author(s)
      Aoyama K, Kang Y, Yazawa K, Gonoi T, Kamei K, Mikami Y
    • Journal Title

      Mycopathologia

      Volume: 168 Pages: 175-183

    • Peer Reviewed
  • [Journal Article] Molecular differentiation and antifungal susceptibility of Candida albicans isolated from patients with respiratory infections in Guiyang Medical College Hospital, China2009

    • Author(s)
      Liu Y, Kang Y, Yokoyama K, Gonoi T, Mikami Y
    • Journal Title

      Jpn J Med Mycol

      Volume: 50 Pages: 175-178

    • Peer Reviewed
  • [Journal Article] 変敗果実加工食品から分離された耐熱性カビNeosartorya paulistensisの生育性状と耐熱性2009

    • Author(s)
      上田成一, 川良希, 矢口貴志, 宇田川俊一
    • Journal Title

      日菌報

      Volume: 50 Pages: 104-113

    • Peer Reviewed
  • [Journal Article] 病原性Aspergillus属2009

    • Author(s)
      矢口貴志
    • Journal Title

      臨床検査

      Volume: 53(2) Pages: 114-116

  • [Journal Article] Aspergillusの有性型2009

    • Author(s)
      矢口貴志
    • Journal Title

      臨床検査

      Volume: 53(3) Pages: 256-257

  • [Journal Article] Paecilomyces-Penicillim2009

    • Author(s)
      矢口貴志
    • Journal Title

      臨床検査

      Volume: 53(4) Pages: 394-396

  • [Journal Article] 病原性接合菌2009

    • Author(s)
      矢口貴志, 西村和子
    • Journal Title

      臨床検査

      Volume: 53(5) Pages: 522-524

  • [Journal Article] 新興真菌症原因菌2009

    • Author(s)
      矢口貴志, 西村和子
    • Journal Title

      臨床検査

      Volume: 53(6) Pages: 654-655

  • [Journal Article] 表在性皮膚真菌症原因菌12009

    • Author(s)
      矢口貴志, 西村和子
    • Journal Title

      臨床検査

      Volume: 53(9) Pages: 968-970

  • [Journal Article] 表在性皮膚真菌症原因菌22009

    • Author(s)
      矢口貴志, 西村和子
    • Journal Title

      臨床検査

      Volume: 53(10) Pages: 1112-1114

  • [Journal Article] 深在性皮膚真菌症原因菌2009

    • Author(s)
      矢口貴志
    • Journal Title

      臨床検査

      Volume: 53(12) Pages: 1514-1516

  • [Journal Article] 真菌の分類と同定2009

    • Author(s)
      矢口貴志
    • Journal Title

      モダンメディア

      Volume: 55(8) Pages: 205-216

  • [Journal Article] Aspergillus属2009

    • Author(s)
      矢口貴志
    • Journal Title

      文化財の虫菌害

      Volume: 58(12) Pages: 17-21

  • [Journal Article] ノカルジア症・放線菌症2009

    • Author(s)
      五ノ井透, 三上襄
    • Journal Title

      Monthly Book Derma

      Volume: No.148 Pages: 65-59

  • [Journal Article] Characterization of Clinical Isolates of Gordonia Species in Japanese Clinical Samples During 1998-20082009

    • Author(s)
      Aoyama K, Kang Y, Yazawa K, Gonoi T, Kamei, K., Mikami, Y
    • Journal Title

      Mycopathologia

      Volume: 53(2) Pages: 112-116

    • Peer Reviewed
  • [Journal Article] Molecular Differentiation and Antifungal Susceptibility of Candida albicans Isolated from Patients with Respiratory Infections in Guiyang Medical College Hospital, China2009

    • Author(s)
      Liu Y, Kang Y, Yokoyama K, Gonoi T, Mikami Y
    • Journal Title

      Jpn J Med Mycol

      Volume: 50 Pages: 175-178

    • Peer Reviewed
  • [Journal Article] Human ZG16p recognizes pathogenic fungi through non-self polyvalent mannose in the

    • Author(s)
      Tateno H, Yabe R, Sato T, Shibasaki A, Shikanai T, Gonoi T, Narimatsu H, Hirabayashi J
    • Journal Title

      digestive system. Glycobiology. In press

    • Peer Reviewed
  • [Presentation] Hanafy A, Kaocharien S, Jover-Botella A, Meyer W, Mikami Y. Multilocus microsatellite analysis in Cryptococcus neoformans var. grubii from 12 different countries2009

    • Author(s)
      Gonoi T
    • Organizer
      The 17th Congress of the International Society for Human and Animal Mycology
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      20090525-29
  • [Presentation] Development of rapid and specifi c molecular discrimination method in the pathogenic Emericella species2009

    • Author(s)
      Matsuzawa T, Yaguchi T, Horie Y, Tanaka R, Gonoi T
    • Organizer
      The 17th Congress of the International Society for Human and Animal Mycology
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      20090525-29
  • [Presentation] Multilocus microsatellite analysis in Cryptococcus neoformans var grubii from 12 different countries. Guest lecture in "Cryptococcois & Aspergillosis"2009

    • Author(s)
      Gonoi T
    • Organizer
      University of Indonesia
    • Place of Presentation
      akarta, Indonesia
    • Year and Date
      2009-10-05
  • [Book] マイコトキシン.微生物資源国際戦略ガイドブック.東京2009

    • Author(s)
      矢口貴志, 辨野義己, 渡邉信, 三上襄, 鈴木健一郎, 高島昌子編
    • Total Pages
      240-244
    • Publisher
      (株)サイエンスフォーラム
  • [Remarks]

    • URL

      http://www.pf.chiba-u.ac.jp/bunya_biseibutsushigen.html

  • [Remarks]

    • URL

      http://www.pf.chiba-u.ac.jp/english/index.html

  • [Patent(Industrial Property Rights)] プローブポリヌクレオチド固定化担体の再生方法2010

    • Inventor(s)
      五ノ井透外
    • Industrial Property Rights Holder
      千葉大学
    • Industrial Property Number
      特願2006-120641
    • Acquisition Date
      2010-04-16
  • [Patent(Industrial Property Rights)] ポリヌクレオチド試料の分析において感度を向上させる方法2010

    • Inventor(s)
      五ノ井透外
    • Industrial Property Rights Holder
      千葉大学
    • Industrial Property Number
      特願2006-117137
    • Acquisition Date
      2010-04-12
  • [Patent(Industrial Property Rights)] 耐熱性菌類の検出方法2009

    • Inventor(s)
      矢口貴志, 弘佑介外
    • Industrial Property Rights Holder
      花王株式会社、千葉大学
    • Industrial Property Number
      特願2009-129475
    • Filing Date
      2009-05-28
    • Overseas

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Published: 2013-07-31  

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