2011 Fiscal Year Final Research Report
International epidemiological studies and standar dization of diagnosis and treatment of autoimmune pulmonary alveolar proteinosis : Research basis of rare lung diseases.
Project/Area Number |
21406025
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 海外学術 |
Research Field |
Respiratory organ internal medicine
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Research Institution | 独立行政法人国立病院機構近畿中央胸部疾患センター(臨床研究センター) (2011) Clinical Research Center, National Hospital Organization, Kinki-Chuo Chest Medical Center (2009-2010) |
Principal Investigator |
INOUE Yoshikazu 独立行政法人国立病院機構近畿中央胸部疾患センター(臨床研究センター), 呼吸不全・難治性肺疾患研究, 部長 (90240895)
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Co-Investigator(Kenkyū-buntansha) |
NAKATA Koh 新潟大学, 医歯学総合病院, 教授 (80207802)
KITAICHI Masanori 独立行政法人国立病院機構(近畿中央胸部疾患センター臨床研究センター), 臨床研究センター室長, 病理部長 (00161464)
AKIRA Masanori 独立行政法人国立病院機構(近畿中央胸部疾患センター臨床研究センター), 臨床研究センター室長, 放射線部長 (20393267)
HIROSE Masaki 独立行政法人国立病院機構(近畿中央胸部疾患センター臨床研究センター), 臨床研究センター流動, 研究員 (90470195)
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Project Period (FY) |
2009 – 2011
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Keywords | 肺胞蛋白症 / 疫学 / 国際標準化 / 稀少肺疾患 / 抗GM-CSF自己抗体 |
Research Abstract |
Pulmonary alveolar proteinosis(PAP) is a rare lung disease characterized by accumulation of surfactant-like materials in the lungs. Based on our new classification by auto-anti GM-CSF antibodies and our Japanese epidemiological data, we performed international standardization of measurements of the auto-antibodies and comparison of autoimmune PAP(collaboration of rare lung disease consortium, USA). We have shown our Japanese guideline for PAP in Europe, USA, and Asia, and preparation of international guideline is going on.
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Research Products
(38 results)
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[Journal Article] Direct evidence that GM-CSF inhalation improves lung clearance in pulmonary alveolar proteinosis2012
Author(s)
Ohashi K, Sato A, Takada T, Arai T, Nei T, Kasahara Y, Motoi N, Hojo M, Urano S, Isii H, Yokoba M, Eda R, Nakayama H, Nasuhara Y, Tsuchihashi Y, Kaneko C, Kanazawa H, Ebina M, Yamaguchi E, Kirchner J, Inoue Y, Nakata K, Tazawa R
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Journal Title
Respir Med
Volume: 106(2)
Pages: 284-93
Peer Reviewed
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[Journal Article] Reduced GM-CSF autoantibody in improved lung of autoimmune pulmonary alveolar proteinosis2012
Author(s)
Ohashi K, Sato A, Takada T, Arai T, Kasahara Y, Hojo M, Nei T, Nakayama H, Motoi N, Urano S, Eda R, Yokoba M, Tsuchihashi Y, Nasuhara Y, Ishii H, Ebina M, Yamaguchi E, Inoue Y, Nakata K, Tazawa R
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Journal Title
Eur Respir J
Volume: 39(3)
Pages: 777-780
Peer Reviewed
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[Journal Article] Clinical features of secondary pulmonary alveolar proteinosis : pre-mortem cases in Japan2011
Author(s)
Ishii H, Tazawa R, Kaneko C, Saraya T, Inoue Y, Hamano E, Kogure Y, Tomii K, Terada M, Takada T, Hojo M, Nishida A, Ichiwata T, Trapnell BC, Goto H, Nakata K
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Journal Title
Eur Respir J
Volume: 37(2)
Pages: 465-8
Peer Reviewed
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[Journal Article] National Institutes of Health Rare Lung Diseases Consortium ; MILES Trial Group. Efficacy and Safety of Sirolimus in Lymphangioleiomyomatosis2011
Author(s)
McCormack FX, Inoue Y, Moss J, Singer LG, Strange C, Nakata K, Barker AF, Chapman JT, Brantly ML, Stocks JM, Brown KK, Lynch JP 3rd, Goldberg HJ, Young LR, Kinder BW, Downey GP, Sullivan EJ, Colby TV, McKay RT, Cohen MM, Korbee L, Taveira-DaSilva AM, Lee HS, Krischer JP, Trapnell BC
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Journal Title
N Engl J Med
Volume: 364(17)
Pages: 1595-6061
Peer Reviewed
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[Journal Article] Polymyxin-B Hemoperfusion for Acute Exacerbation of Idiopathic Pulmonary Fibrosis : Serum IL-7 as a Prognostic Marker2011
Author(s)
Tachibana K, Inoue Y, Nishiyama A, Sugimoto C, Matsumuro A, Hirose M, Kitaichi M, Akira M, Arai T, Hayashi S, Inoue Y
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Journal Title
Sarcoidosis vasculitis and diffuse lung diseases
Volume: 28(2)
Pages: 113-22
Peer Reviewed
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[Journal Article] 全肺洗浄を施行した自己免疫性肺胞蛋白症8例の手技,効果,安全性の多面的評価2011
Author(s)
杉本親寿,新井徹,西山明秀,井上康,香川智子,審良正則,松室昭子,広瀬雅樹,北市正則,林清二,井上義一
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Journal Title
日本呼吸器学会雑誌
Volume: 49(8)
Pages: 569-576
Peer Reviewed
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[Journal Article] Inhaled granulocyte/macrophage-colony stimulating factor as therapy for pulmonary alveolar proteinosis2010
Author(s)
Tazawa R, Trapnell BC, Inoue Y, Arai T, Takada T, Nasuhara Y, Hizawa N, Kasahara Y, Tatsumi K, Hojo M, Ishii H, Yokoba M, Tanaka N, Yamaguchi E, Eda R, Tsuchihashi Y, Morimoto K, Akira M, Terada M, Otsuka J, Ebina M, Kaneko C, Nukiwa T, Krischer JP, Akazawa K, Nakata K
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Journal Title
Am J Respir Crit Care Med
Volume: 181(12)
Pages: 1345-54
Peer Reviewed
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[Journal Article] Serum Vascular Endothelial Growth Factor-D Prospectively Distinguishes Lymphangioleiomyomatosis from Other Diseases2010
Author(s)
Young LR, Vandyke R, Gulleman PM, Inoue Y, Brown KK, Schmidt LS, Linehan WM, Hajjar F, Kinder BW, Trapnell BC, Bissler JJ, Franz DN, McCormack FX
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Journal Title
Chest
Volume: 138(3)
Pages: 674-81
Peer Reviewed
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[Journal Article] The international LAM registry : a component of an innovative web-based clinician, researcher, and patient-driven rare disease research platform2010
Author(s)
Nurok M, Eslick I, Carvalho CR, Costabe lU, D' Armiento J, Glanville AR, Harari S, Henske EP, Inoue Y, Johnson SR, Lacronique J, Lazor R, Moss J, Ruoss SJ, Ryu JH, Seyama K, Watz H, Xu KF, Hohmann EL, Moss F
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Journal Title
Lymphat Res Biol
Volume: 8(1)
Pages: 81-87
Peer Reviewed
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[Journal Article] Comparative Study of High-Resolution CT Findings between Autoimmune and Secondary Pulmonary Alveolar Proteinosis2009
Author(s)
Ishii H, Trapnell BC, Tazawa R, Inoue Y, Akira M, Kogure Y, Tomii K, Takada T, Hojo M, Ichiwata T, Goto H, Nakata K
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Journal Title
Chest
Volume: 136
Pages: 1348-1355
Peer Reviewed
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[Presentation] Serum CYFRA reflects disease severity of autoimmune pulmonary alveolar proteinosis, Session 89, Thematic Poster Session : Rare diffuse lung diseases2010
Author(s)
T. Arai, Y. Inoue, C. Sugimoto, A. Matsumuro, Y. Iwaki, M. Hirose, M. Kitaichi, M. Akira, S. Hayashi, K. Nakata, M. Sakatani
Organizer
ERS 2010, Fira Barcelona.
Place of Presentation
Barcelona, Spain
Year and Date
20100918-22
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[Presentation] Quantitative CT in pulmonary lymphangioleiomyomatosis : Comparisonwith pulmonary dysfunction, Session 89, Thematic Poster Session : Rare diffuse lung diseases2010
Author(s)
Y. Inoue, M. Akira, M. Hirose, T. Arai, T. Okuma, Y. Iwaki, C. Sugimoto, K. Tachibana, M. Akiko, M. Nakagawa, M. Kitaichi, S. Hayashi, M. Okada, M. Sakatani
Organizer
ERS 2010, Fira Barcelona.
Place of Presentation
Barcelona, Spain
Year and Date
20100918-22
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[Presentation] Serum Vascular Endothelial Growth Factor(VEGF)-D in lymphangioleiomyomatosis(LAM)2009
Author(s)
Masaki Hirose, Yoshikazu Inoue, Akiko Matsumuro, Toru Arai, Chikatoshi Sugimoto, Kazunobu Tachibana, Akihide Nishiyama, Seiji. Hayashi, Masaji Okada, Mitsunori Sakatani
Organizer
14^<th> Congress of the APSR and 3^<rd> Joint Congress of the APSR/ACCP
Place of Presentation
COEX, Seoul, Korea
Year and Date
20091114-18
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[Presentation] Japanese Center of RLDC, Osaka Symposium on Respiratory Disease. Intercurrent intractable factors in autoimmune pulmonary alveolar proteinosis(Thematic Poster Session : Various 5 backgrounds in diffuse parenchymal Lung P. 757)2009
Author(s)
Y. Inoue, T. Arai, M. Kitaichi, M. Akira, K. Nakata, R. Tazawa, J. Otsuka, M. Hirose, A. Matsumuro, M. Sakatani
Organizer
ERS Vienna 2009 Austria
Place of Presentation
Sakai, Niigata, Japan
Year and Date
20090912-16
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[Presentation] Profile of Th1/Th2 Cytokines in Autoimmune Pulmonary Alveolar Proteinosis2009
Author(s)
Y Inoue, A Matsumuro, M Hirose, T Arai, J Otsuka, C Sugimoto, S Minamoto, A Nishiyama, K Sugiyama, M Nakagawa, M Kitaichi, M Akira, S Hayashi, K Nakata, M Okada, and M Sakatani
Organizer
ATS 2009 San Diego International conference
Place of Presentation
San Diego, California, USA
Year and Date
20090515-20
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[Presentation] Impact of Th2 cytokines in Lymphangioleiomyomatos2009
Author(s)
M Hirose, Y Inoue, A Matsumuro, T Arai, C Sugimoto, S Minamoto, K Tachibana, M Akira, M Kitaichi, S Hayashi, K Sugiyama, M Nakagawa, M Okada, and M Sakatani
Organizer
ATS 2009 San Diego International conference
Place of Presentation
San Diego, California, USA
Year and Date
20090515-20
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