Impacts of Congenital Infections : A Birth Cohort Study in a Mid Southern Region in Vietnam

2011 Fiscal Year Final Research Report

• Project/Area Number: 21406028
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Nagasaki University
• Principal Investigator: MORIUCHI Hiroyuki 長崎大学, 大学院・医歯薬学総合研究科, 教授 (90315234)
• Co-Investigator(Kenkyū-buntansha): ARIYOSHI Koya 長崎大学, 熱帯医学研究所, 教授 (30311400) ; OHSAWA Kazutaka 長崎大学, 先導生命科学研究支援センター, 教授 (90244756)
• Project Period (FY): 2009 – 2011
• Keywords: 感染症 / 社会医学 / 微生物 / ウイルス / 脳神経疾患

Research Abstract

Mother-to-child infections in a mid-southern region in Vietnam were investigated in a birth cohort study. A total of 2222 pairs of mothers and their babies were enrolled. Incidences of congenital cytomegalovirus infection and congenital rubella were 0. 54% and 0. 13%, respectively. 12. 5% of mothers were hepatitis B virus(HBV) carriers, and 58. 8% of them showed evidence of current or past HBV infection. Rubella outbreak in early 2011 led to the occurrence of congenital rubella syndrome(CRS), and a total of 36 CRS babies have been investigated in their epidemiological and clinical aspects up to now.

Research Products

• [Journal Article] Maternal body mass index and gestational weight gain and their association with perinatal outcomes in Viet Nam (2011)
  • Author(s): Ota E, Haruna M, Suzuki M, Anh DD, Tho LH, Tam NTT, Thiem VD, Hien Anh NT, Isozaki M, Shibuya K, Ariyoshi K, Murashima S, Moriuchi H, Yanai H.
  • Journal Title: Bull WHO Volume: 89 Pages: 127-136
  • Peer Reviewed
• [Journal Article] Japanese Congenital Cytomegalovirus Study Group. Screening for congenital cytomegalovirus infection using newborn urine samples collected on filter paper : feasibility and outcomes from a multicenter study (2011)
  • Author(s): Koyano S, Inoue N, Oka A, Moriuchi H, Asano K, Ito Y, Yamada H, Yoshikawa T, Suzutani T
  • Journal Title: BMJ Open Volume: 1 Pages: E000118
  • Peer Reviewed
• [Journal Article] 先天性CMV感染症治療プロトコール (2011)
  • Author(s): 森内浩幸
  • Journal Title: 小児感染免疫 Volume: 22 Pages: 385-389
  • Peer Reviewed
• [Journal Article] Seroepidemiological Survey of Cytomegalovirus Infection among Pregnant Women in Nagasaki (2010)
  • Author(s): Tagawa M, Minematsu T, Masuzaki H, Ishimaru T, Moriuchi H.
  • Journal Title: Japan. Pediatr Int Volume: 52 Pages: 459-462
  • Peer Reviewed
• [Journal Article] Detection of cytomegalovirus in preserved umbilical cord from a boy with autistic disorder (2010)
  • Author(s): Kawatani M, Nakai A, Okuno T, Kobata R, Moriuchi M, Moriuchi H, et al.
  • Journal Title: Pediatr Int Volume: 52 Pages: 304-307
  • Peer Reviewed
• [Presentation] A Birth Cohort Study on Congenital Cytomegalovirus Infection in Khanh HoaProvince, Vietnam (2011)
  • Author(s): Motomura H, Miyakawa M, Moriuchi M, Yoshino H, Yoshida LM, Minematsu T, Tho LH, Ariyoshi K, Anh DD, Moriuchi H.
  • Organizer: Pediatric Academic Societies(PAS)/ ASPRJoint Meeting
  • Place of Presentation: デンバー(米国)
  • Year and Date: 20110430-0501
• [Presentation] Mother-to-child transmission of cytomegalovirus and human T-cell leukemia virus (2011)
  • Author(s): Moriuchi H, Moriuchi M.
  • Organizer: PAS/ ASPR Joint Meeting
  • Place of Presentation: デンバー(米国)
  • Year and Date: 20110430-0501
• [Presentation] Emerging Pediatric Pathogens : A Symposium of Experience and Perspective Across Cultures and Continents" The View from Asia" (2011)
  • Author(s): Moriuchi H.
  • Organizer: PAS/ ASPR Joint Meeting
  • Place of Presentation: デンバー(米国)
  • Year and Date: 20110430-0501
• [Presentation] A multi-center study on the treatment of congenital CMV infection in Japan (2010)
  • Author(s): Moriuchi H, Morioka I, Yamada H, Imamura T, Asano K, Oka A, et al.
  • Organizer: 3^<rd> Congenital CMV Conference
  • Place of Presentation: パリ(フランス)
  • Year and Date: 20100923-25
• [Presentation] The Incidence and Prognosis of Congenital Cytomegalovirus infection in Japan and Vietnam (2010)
  • Author(s): Miyakawa M, Doi M, Motomura H, Moriuchi M, Yoshino H, Yoshida L, Ariyoshi K, Tho LH, Anh DD, Inoue N, Moriuchi H.
  • Organizer: Asian Society for Pediatric Research(ASPR) Annual Meeting
  • Place of Presentation: 台北(台湾)
  • Year and Date: 20100415-18